Development of Biosensors for Detection/ Diagnostic Purposes

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 1792

Special Issue Editors


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Guest Editor
Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia
Interests: SELEX; aptamer; biosensors; aptasensor; nanobiosensors; disease diagnostics; cancer biology
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Guest Editor
Life Science and Health, The University of Nottingham, Ningbo, China
Interests: food safety; nanomaterial; biosensors; healthcare

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Guest Editor
Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, Doha 2713, Qatar
Interests: molecularly imprinted polymers; biosensors; nanotechnology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Research and Innovation Center for Graphene and 2D Materials (RIC-2D), Khalifa University, Abu Dhabi, United Arab Emirates
Interests: MXenes; biosensors; nanotechnology

Special Issue Information

Dear Colleagues,

Biosensors are analytical tools that are composed of a biological or synthetic element known as a receptor, such as antibodies, enzymes, nucleic acids/aptamers, and others. These receptors are in close proximity to a transducer, which can convert the receptor's response into a measurable signal by detecting an analyte, which is a chemical or biochemical species of interest. The development of biosensors has recently attracted a lot of attention in the fields of research and development, primarily due to the interest in their potential applications across various sectors like environmental monitoring, healthcare, food safety/ security, and other industries. These devices must meet the following characteristics for several applications: specificity, sensitivity, rapidity, user friendliness, affordability, portability, ease of specimen collection, real-time connectivity, and robustness. Biosensors will be even more useful and easier to get when they are combined with new communication technologies. This will make these devices even more important for custom healthcare and environmental monitoring systems.

Researchers from various scientific fields, such as biology, environmental science, chemistry, engineering, medicine, and material science, are invited to submit original and review articles that highlight the latest advancements in biosensor development. This Special Issue “Development of Biosensors for Detection/ Diagnostic Purposes” seeks to offer a thorough investigation of the most recent progress and innovations in the development of biosensors that are specifically designed for the following uses:

  • The detection and diagnosis of a wide range of diseases, such as COVID, diabetes, infectious diseases, cancer biomarkers, hormones, vitamins, heart-related conditions, and others.
  • The development of biosensors to identify environmental pollutants and food contaminants, such as pesticides, heavy metals, antibiotic residues, and toxic substances, in environmental or food samples.
  • Wearable biosensors that are used to monitor analytes in biofluids, such as sweat, saliva, serum, urine, and blood, for tailored healthcare purposes.
  • The advancement of innovative biosensors, including nanomaterial-based biosensors, antibody/aptamer-based biosensors, electrochemical biosensors, optical biosensors, colorimetric biosensors, surface-enhanced Raman scattering (SERs)-based biosensors, fluorescent biosensors, and molecularly imprinted polymers (MIPs).
  • The development of biosensing technologies, such as microfluidic biosensors and smartphone-based biosensors, particularly in the field of detection and diagnosis. This Special Issue also encompasses the applications of automation, machine learning, and deep learning techniques in the field of biosensor development.

Submissions for this Special Issue must adhere to the regular criteria for regular "Biosensors" articles and be pertinent to a wide-ranging international and interdisciplinary readership. Special Issue papers are subject to the same criteria of quality, innovation, and significance.

Dr. Qurat ul ain Zahra
Dr. Imran Mahmood Khan
Dr. Shabi Abbas Zaidi
Dr. Faisal Shahzad
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanobiosensors
  • aptasensors
  • MIP-based biosensors
  • environmental monitoring
  • food safety
  • disease diagnostics
  • electrochemical biosensors
  • optical biosensors
  • colorimetric biosensors
  • SERs based biosensors
  • fluorescent biosensors

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Published Papers (1 paper)

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Research

15 pages, 3162 KiB  
Article
Design and Characterization of a Dual-Protein Strategy for an Early-Stage Assay of Ovarian Cancer Biomarker Lysophosphatidic Acid
by Katharina Davoudian, Sandro Spagnolo, Navina Lotay, Monika Satkauskas, Gábor Mészáros, Tibor Hianik, Zsófia Keresztes, Gilbert Walker and Michael Thompson
Biosensors 2024, 14(6), 287; https://doi.org/10.3390/bios14060287 - 2 Jun 2024
Viewed by 1306
Abstract
The overall 5-year survival rate of ovarian cancer (OC) is generally low as the disease is often diagnosed at an advanced stage of progression. To save lives, OC must be identified in its early stages when treatment is most effective. Early-stage OC causes [...] Read more.
The overall 5-year survival rate of ovarian cancer (OC) is generally low as the disease is often diagnosed at an advanced stage of progression. To save lives, OC must be identified in its early stages when treatment is most effective. Early-stage OC causes the upregulation of lysophosphatidic acid (LPA), making the molecule a promising biomarker for early-stage detection. An LPA assay can additionally stage the disease since LPA levels increase with OC progression. This work presents two methods that demonstrate the prospective application for detecting LPA: the electromagnetic piezoelectric acoustic sensor (EMPAS) and a chemiluminescence-based iron oxide nanoparticle (IONP) approach. Both methods incorporate the protein complex gelsolin–actin, which enables testing for detection of the biomarker as the binding of LPA to the complex results in the separation of gelsolin from actin. The EMPAS was characterized with contact angle goniometry and atomic force microscopy, while gelsolin–actin-functionalized IONPs were characterized with transmission electron microscopy and Fourier transform infrared spectroscopy. In addition to characterization, LPA detection was demonstrated as a proof-of-concept in Milli-Q water, buffer, or human serum, highlighting various LPA assays that can be developed for the early-stage detection of OC. Full article
(This article belongs to the Special Issue Development of Biosensors for Detection/ Diagnostic Purposes)
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