Biomimetic Strategies and Artificial Optical Biosensors
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".
Deadline for manuscript submissions: closed (20 August 2024) | Viewed by 2280
Special Issue Editors
Interests: optical biosensors; chemiluminescence biosensors; chemosensors; paper-based devices
Special Issues, Collections and Topics in MDPI journals
Interests: optical biosensors; chemiluminescence biosensors; chemosensors; paper-based devices
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Receptors or enzymes generated by natural evolution in living organisms show a surprising ability to specifically recognize target molecules. When used as biosensor recognition elements, these biomolecules provide very high selectivity. However, they suffer from instability and low durability. The design of alternative robust artificial receptors and antibodies circumvents these limits.
For instance, an antibody can be successfully replaced by a corresponding molecularly imprinted polymer (MIP), sometimes called a ‘plastic antibody’, or by aptamers that are oligonucleotides that bind one or more specific target molecules.
On the other hand, enzymes are macromolecular biological catalysts that accelerate chemical reactions. The use of natural enzymes can encounter some challenges. Lately, nucleic acids that exhibit catalytic properties have attracted growing interest because they have certain advantages in comparison with traditional protein enzymes. DNAzymes are DNA-based catalysts, representing an important class of functional DNA, which have been widely used because of their excellent activity, programmability, signal amplification through catalytic turnover, high chemical stability, simple synthesis, and easy modification.
The topic of this Special Issue is related to biomimetic detection exploiting alternatives to natural receptors, such as antibodies, enzymes, etc., separated into the following categories:
(1) Artificial receptors as molecularly imprinted polymers and aptamers etc.
(2) Nucleic acids and nanozymes, nanoparticles or soft (sol–gel, hydrogel, etc.) and self-assembled materials used as artificial enzymes or extracellular matrix.
Dr. Donato Calabria
Dr. Mara Mirasoli
Guest Editors
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Keywords
- biomimetic biosensors
- molecularly imprinted polymer
- DNAzyme
- enzyme-like activity
- aptamers
- catalytic nanomaterials
- soft and self-assembled biomaterials
- optical selection
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