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Biosensors
Special Issues
Biosensing Technologies for Nucleic Acid Detection
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Biosensing Technologies for Nucleic Acid Detection

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3020

Special Issue Editors

Prof. Dr. Xianqiang Mi

E-Mail Website
Guest Editor
Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China
Interests: biomarkers; DNA
Dr. Yifan Liu

E-Mail Website
Guest Editor
Division of Chemistry and Physical Biology, School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China
Interests: microfluidics; single-cell analysis

Special Issue Information

Dear Colleagues,

Sensing and quantifying nucleic acids are significant for modern clinical diagnosis and life science research. Recently, the techniques for detecting nucleic acid have seen marked breakthroughs in the major metrics such as limit of detection (LOD), dynamic range, and response time, partially driven by the pandemic of COVID-19. This Special Issue aims to provide a platform for the latest works related to Biosensing Technologies for Nucleic Acid Detection. We welcome topics of new sensing strategies, materials, interfaces, integrations and systems for nucleic acid detection.

Prof. Dr. Xianqiang Mi
Dr. Yifan Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nucleic acid
  • biosensing
  • microfluidics
  • lab on a chip
  • point-of-care
  • droplet
  • diagnosis

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Published Papers (1 paper)

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Research

9 pages, 2425 KiB  
Article
Nanodroplet-Based Reagent Delivery into Water-in-Fluorinated-Oil Droplets
by Bo Zhu, Zhe Du, Yancen Dai, Tetsuya Kitaguchi, Sebastian Behrens and Burckhard Seelig
Biosensors 2023, 13(8), 768; https://doi.org/10.3390/bios13080768 - 28 Jul 2023
Viewed by 2516
Abstract
In vitro compartmentalization (IVC) is a technique for generating water-in-oil microdroplets to establish the genotype (DNA information)–phenotype (biomolecule function) linkage required by many biological applications. Recently, fluorinated oils have become more widely used for making microdroplets due to their better biocompatibility. However, it [...] Read more.
In vitro compartmentalization (IVC) is a technique for generating water-in-oil microdroplets to establish the genotype (DNA information)–phenotype (biomolecule function) linkage required by many biological applications. Recently, fluorinated oils have become more widely used for making microdroplets due to their better biocompatibility. However, it is difficult to perform multi-step reactions requiring the addition of reagents in water-in-fluorinated-oil microdroplets. On-chip droplet manipulation is usually used for such purposes, but it may encounter some technical issues such as low throughput or time delay of reagent delivery into different microdroplets. Hence, to overcome the above issues, we demonstrated a nanodroplet-based approach for the delivery of copper ions and middle-sized peptide molecules (human p53 peptide, 2 kDa). We confirmed the ion delivery by microscopic inspection of crystal formation inside the microdroplet, and confirmed the peptide delivery using a fluorescent immunosensor. We believe that this nanodroplet-based delivery method is a promising approach to achieving precise control for a broad range of fluorocarbon IVC-based biological applications, including molecular evolution, cell factory engineering, digital nucleic acid detection, or drug screening. Full article
(This article belongs to the Special Issue Biosensing Technologies for Nucleic Acid Detection)
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