Advancing Biomedical Biosensing with Microelectrode Arrays

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 3914

Special Issue Editors


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Guest Editor
Department of Chemistry, University of Toronto, Toronto, ON M5S 1A1, Canada
Interests: biosensor technology; acoustic wave detection; chemical sensors; biocompatibility; surface chemistry and analysis
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Guest Editor
Department of Chemistry, University of Toronto, Toronto, ON M5S 1A1, Canada
Interests: electrochemistry, sensors, biosensors, electrochemical sensors,analytical chemistry, bioanalytical chemistry; Alzheimer's disease; metal-protein interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advances in the design of microelectrode arrays allow for the possibility of developing devices capable of multiplexed biomarker assays under clinical conditions. The advent of the relatively new strategy of precision medicine, which involves biomarker detection for patient disease monitoring and treatment, requires the concomitant assay of several analytes. The microelectrode array configuration offers such an opportunity to measure the concentration of species both in vitro and, potentially, in vivo. In order to achieve these goals, the technology requires that probes for various species of interest are attached to electrodes in the array. Further, it is necessary that the interaction of probes with analytics in clinical samples be interrogated via an electrochemical methodology. An additional requirement is that each electrode of the array must be capable of avoiding the interfering effects associated with non-specific adsorption in, for example, serum. Advances with respect to these criteria render the microelectrode array a unique and exciting technology for application in the field of precision medicine.  

Prof. Dr. Michael Thompson
Dr. Soha Ahmadi
Guest Editors

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Keywords

  • microelectrode sensors
  • medical biosensing
  • multiplexed biomarker assay

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Published Papers (1 paper)

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Research

12 pages, 4146 KiB  
Article
Rapid Surface Charge Mapping Based on a Liquid Crystal Microchip
by Leixin Ouyang, Heyi Chen, Ruiting Xu, Rubia Shaik, Ge Zhang and Jiang Zhe
Biosensors 2024, 14(4), 199; https://doi.org/10.3390/bios14040199 - 18 Apr 2024
Viewed by 3408
Abstract
Rapid surface charge mapping of a solid surface remains a challenge. In this study, we present a novel microchip based on liquid crystals for assessing the surface charge distribution of a planar or soft surface. This chip enables rapid measurements of the local [...] Read more.
Rapid surface charge mapping of a solid surface remains a challenge. In this study, we present a novel microchip based on liquid crystals for assessing the surface charge distribution of a planar or soft surface. This chip enables rapid measurements of the local surface charge distribution of a charged surface. The chip consists of a micropillar array fabricated on a transparent indium tin oxide substrate, while the liquid crystal is used to fill in the gaps between the micropillar structures. When an object is placed on top of the chip, the local surface charge (or zeta potential) influences the orientation of the liquid crystal molecules, resulting in changes in the magnitude of transmitted light. By measuring the intensity of the transmitted light, the distribution of the surface charge can be accurately quantified. We calibrated the chip in a three-electrode configuration and demonstrated the validity of the chip for rapid surface charge mapping using a borosilicate glass slide. This chip offers noninvasive, rapid mapping of surface charges on charged surfaces, with no need for physical or chemical modifications, and has broad potential applications in biomedical research and advanced material design. Full article
(This article belongs to the Special Issue Advancing Biomedical Biosensing with Microelectrode Arrays)
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