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Micromachines
Special Issues
Recent Trends in Biosensors
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Recent Trends in Biosensors

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 12311

Special Issue Editors

Prof. Dr. Kagan Kerman

E-Mail Website
Guest Editor
Department of Physical & Environmental Sciences, University of Toronto Scarborough, Room SW533, 1265 Military Trail, Toronto, ON M1C 1A4, Canada
Interests: electrochemical sensors; biosensors; immunosensors; DNA; nanomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Soha Ahmadi

E-Mail Website
Guest Editor
Department of Chemistry, University of Toronto, Toronto, ON M5S 1A1, Canada
Interests: electrochemistry, sensors, biosensors, electrochemical sensors,analytical chemistry, bioanalytical chemistry; Alzheimer's disease; metal-protein interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Immunosensors are affinity-based bioanalytical systems that have attracted extensive attention in the last decade because of their wide practical applications with the potential to be the next-generation of biosensors. The outstanding advantages of immunosensors, such as their high selectivity, sensitivity, and accuracy, which are attributed to their specific immunorecognition system, make them ideal for clinical diagnosis, pathogen detection, drug screening, biomarkers detection, and point-of-care testing. Recent advances using nanomaterials and genetic engineering on aptamers to design novel immunosensors have made a great impact on improving their performance by refining the immobilization of immunoreagents and introducing new molecular recognition elements. Combining microfluidics, lab-on-a-chip, and array-based multiple analytes detection with immunosensors has greatly influenced the future of bio-recognition systems toward high-throughput detection, automatization, and miniaturization. It is expected that these properties, together with the low sample size and simple operation of immunosensors, bring an enormous commercial value for these bioanalytical devices in the near future. This Special Issue seeks to showcase research papers, short communications, and review articles that focus on the recent progress of a novel strategy to design immunosensors for various application. In particular, topics of interest include, but are not limited to, electrochemical and optical immunosensors, photoelectrochemical immunosensors, immunosensors based on aptamers, and nanomaterial-modified immunosensors, as well as those combined with microfluidics, lab-on-a-chip, and array-based multiplexed detection systems.

Prof. Dr. Kagan Kerman
Dr. Soha Ahmadi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Immunosensors
  • Photoelectrochemical immunosensors
  • Immunosensors based on aptamers
  • Nanomaterial-modified immunosensors
  • Immunosensors and microfluidics
  • Immunosensors and lab-on-a-chip
  • Array-based multiplexed detection

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Published Papers (3 papers)

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Research

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17 pages, 5092 KiB  
Article
Electrografting a Hybrid Bilayer Membrane via Diazonium Chemistry for Electrochemical Impedance Spectroscopy of Amyloid-β Aggregation
by Hamid Fini, Qusai Hassan, Meissam Noroozifar and Kagan Kerman
Micromachines 2022, 13(4), 574; https://doi.org/10.3390/mi13040574 - 5 Apr 2022
Cited by 1 | Viewed by 2087
Abstract
Herein, a novel hybrid bilayer membrane is introduced as a platform to study the aggregation of amyloid-β1–42 (Aβ1–42) peptide on surfaces. The first layer was covalently attached to a glassy carbon electrode (GCE) via diazonium electrodeposition, which provided a highly [...] Read more.
Herein, a novel hybrid bilayer membrane is introduced as a platform to study the aggregation of amyloid-β1–42 (Aβ1–42) peptide on surfaces. The first layer was covalently attached to a glassy carbon electrode (GCE) via diazonium electrodeposition, which provided a highly stable template for the hybrid bilayer formation. To prepare the long-chain hybrid bilayer membrane (lcHBLM)-modified electrodes, GCE surfaces were modified with 4-dodecylbenzenediazonium (DDAN) followed by the modification with dihexadecyl phosphate (DHP) as the second layer. For the preparation of short-chain hybrid bilayer membrane (scHBLM)-modified electrodes, GCE surfaces were modified with 4-ethyldiazonium (EDAN) as the first layer and bis(2-ethylhexyl) phosphate (BEHP) was utilized as the second layer. X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) were used to characterize the bilayer formation. Both positively charged [Ru(NH3)6]3+ and negatively charged ([Fe(CN)6]3-/4-) redox probes were used for electrochemical characterization of the modified surfaces using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). EIS results showed a decrease in charge transfer resistance (Rct) upon incubation of Aβ1–42 on the hybrid bilayer-modified surfaces. This framework provides a promising electrochemical platform for designing hybrid bilayers with various physicochemical properties to study the interaction of membrane-bound receptors and biomolecules on surfaces. Full article
(This article belongs to the Special Issue Recent Trends in Biosensors)
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13 pages, 2965 KiB  
Article
Cobalt Phthalocyanine-Ionic Liquid Composite Modified Electrodes for the Voltammetric Detection of DNA Hybridization Related to Hepatitis B Virus
by Ece Yaralı and Arzum Erdem
Micromachines 2021, 12(7), 753; https://doi.org/10.3390/mi12070753 - 26 Jun 2021
Cited by 3 | Viewed by 2020
Abstract
In this study, cobalt phthalocyanine (CoPc) and ionic liquid (IL) modified pencil graphite electrodes (PGEs) were designed and implemented to detect sequence-selective DNA hybridization related to the Hepatitis B virus (HBV). The surface characterization of CoPc-IL-PGEs was investigated by scanning electron microscopy (SEM), [...] Read more.
In this study, cobalt phthalocyanine (CoPc) and ionic liquid (IL) modified pencil graphite electrodes (PGEs) were designed and implemented to detect sequence-selective DNA hybridization related to the Hepatitis B virus (HBV). The surface characterization of CoPc-IL-PGEs was investigated by scanning electron microscopy (SEM), and the electrochemical behavior of electrodes were studied by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) techniques. The voltammetric detection of hybridization was investigated by evaluating the guanine oxidation signal, measured by differential pulse voltammetry (DPV) technique. The implementation of our biosensor to serum samples was also examined using fetal bovine serum (FBS). The detection limit was established as 0.19 µg/mL in phosphate buffer solution (PBS) (pH 7.40) and 2.48 µg/mL in FBS medium. The selectivity of our assay regarding HBV DNA hybridization in FBS medium was tested in the presence of other DNA sequences. With this aim, the hybridization of DNA probe with non-complementary (NC) or mismatched DNA sequence (MM), or in the presence of mixture samples containing DNA target NC (1:1) or DNA target MM (1:1), was studied based on the changes in guanine signal. Full article
(This article belongs to the Special Issue Recent Trends in Biosensors)
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Review

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21 pages, 5273 KiB  
Review
Electrochemical Biosensors for the Detection of SARS-CoV-2 and Other Viruses
by Saim Imran, Soha Ahmadi and Kagan Kerman
Micromachines 2021, 12(2), 174; https://doi.org/10.3390/mi12020174 - 10 Feb 2021
Cited by 52 | Viewed by 7272
Abstract
The last few decades have been plagued by viral outbreaks that present some of the biggest challenges to public safety. The current coronavirus (COVID-19) disease pandemic has exponentiated these concerns. Increased research on diagnostic tools is currently being implemented in order to assist [...] Read more.
The last few decades have been plagued by viral outbreaks that present some of the biggest challenges to public safety. The current coronavirus (COVID-19) disease pandemic has exponentiated these concerns. Increased research on diagnostic tools is currently being implemented in order to assist with rapid identification of the virus, as mass diagnosis and containment is the best way to prevent the outbreak of the virus. Accordingly, there is a growing urgency to establish a point-of-care device for the rapid detection of coronavirus to prevent subsequent spread. This device needs to be sensitive, selective, and exhibit rapid diagnostic capabilities. Electrochemical biosensors have demonstrated these traits and, hence, serve as promising candidates for the detection of viruses. This review summarizes the designs and features of electrochemical biosensors developed for some past and current pandemic or epidemic viruses, including influenza, HIV, Ebola, and Zika. Alongside the design, this review also discusses the detection principles, fabrication techniques, and applications of the biosensors. Finally, research and perspective of biosensors as potential detection tools for the rapid identification of SARS-CoV-2 is discussed. Full article
(This article belongs to the Special Issue Recent Trends in Biosensors)
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