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Biosensors
Special Issues
Advances in Lab-on-Chip Devices II
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Advances in Lab-on-Chip Devices II

A special issue of Biosensors (ISSN 2079-6374).

Deadline for manuscript submissions: closed (31 May 2019) | Viewed by 15998

Special Issue Editor

Prof. Dr. Domenico Caputo

E-Mail Website
Guest Editor
Department of Information Engineering, Electronics and Telecommunications, University of Rome “La Sapienza”, via Eudossiana, 18, 00184 Rome, Italy
Interests: electronic devices; photosensors; electronics for photosensors; lab-on-chip; microfluidics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Sssue will be dedicated to the advances in lab-on-chip system.

Topics of the issue are focused on:

Novel materials and/or technologies for lab-on-chip development;

Design and fabrication of microfluidic networks;

Thin film electronic devices (based on organic and inorganic materials) for treatment and detection of biomolecules;

Label-free and labeled detection;

Novel surface functionalization for microfluidic systems;

Recognition methods based on antibodies, aptamers, quantum dots, graphene and nanoparticles;

Applications regarding agro-food analysis, forensic science, health care and diagnostics.

Prof. Domenico Caputo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lab-on-chip
  • microfluidic networks
  • surface chemistry treatments
  • thin film devices
  • label-free and labeled detection
  • biomolecular recognition

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Published Papers (2 papers)

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Research

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14 pages, 2054 KiB  
Article
Cyclic Olefin Copolymer Microfluidic Devices for Forensic Applications
by Brigitte Bruijns, Andrea Veciana, Roald Tiggelaar and Han Gardeniers
Biosensors 2019, 9(3), 85; https://doi.org/10.3390/bios9030085 - 4 Jul 2019
Cited by 37 | Viewed by 7799
Abstract
Microfluidic devices offer important benefits for forensic applications, in particular for fast tests at a crime scene. A large portion of forensic applications require microfluidic chip material to show compatibility with biochemical reactions (such as amplification reactions), and to have high transparency in [...] Read more.
Microfluidic devices offer important benefits for forensic applications, in particular for fast tests at a crime scene. A large portion of forensic applications require microfluidic chip material to show compatibility with biochemical reactions (such as amplification reactions), and to have high transparency in the visible region and high chemical resistance. Also, preferably, manufacturing should be simple. The characteristic properties of cyclic olefin copolymer (COC) fulfills these requirements and offers new opportunities for the development of new forensic tests. In this work, the versatility of COC as material for lab-on-a-chip (LOC) systems in forensic applications has been explored by realizing two proof-of-principle devices. Chemical resistance and optical transparency were investigated for the development of an on-chip presumptive color test to indicate the presence of an illicit substance through applying absorption spectroscopy. Furthermore, the compatibility of COC with a DNA amplification reaction was verified by performing an on-chip multiple displacement amplification (MDA) reaction. Full article
(This article belongs to the Special Issue Advances in Lab-on-Chip Devices II)
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Review

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26 pages, 6597 KiB  
Review
Dielectrophoresis Manipulation: Versatile Lateral and Vertical Mechanisms
by Muhamad Ramdzan Buyong, Aminuddin Ahmad Kayani, Azrul Azlan Hamzah and Burhanuddin Yeop Majlis
Biosensors 2019, 9(1), 30; https://doi.org/10.3390/bios9010030 - 26 Feb 2019
Cited by 29 | Viewed by 7503
Abstract
Discussing the topic of the capability of dielectrophoresis (DEP) devices in terms of the selective detection and rapid manipulation of particles based on the DEP force (FDEP) via contactless methods is challenging in medical research, drug discovery and delivery. Nonetheless, the [...] Read more.
Discussing the topic of the capability of dielectrophoresis (DEP) devices in terms of the selective detection and rapid manipulation of particles based on the DEP force (FDEP) via contactless methods is challenging in medical research, drug discovery and delivery. Nonetheless, the process of the selective detection and rapid manipulation of particles via contactless DEP based on dielectric particles and the surrounding medium can reduce the effects of major issues, including physical contact with the particles and medium contamination to overcome operational difficulties. In this review, DEP microelectromechanical system (MEMS) microelectrodes with a tapered profile for the selective detection and rapid manipulation of particles were studied and compared with those of conventional designs with a straight-cut profile. The main objective of this manuscript is to review the versatile mechanism of tapered DEP MEMS microelectrodes for the purpose of selective detection and rapid manipulation. Thus, this review provides a versatile filtration mechanism with the potential for a glomerular-based membrane in an artificial kidneys’ development solution for implementing engineered particles and cells by lateral attraction as well as vertical repulsion in the development of lab-on-a-chip applications. For tapered DEP MEMS microelectrodes, the scope of this study methodology involved the characterisation of DEP, modelling of the polarisation factor and the dynamic dielectric changes between the particles and medium. Comprehensive discussions are presented on the capability of tapered DEP microelectrodes to drive the selected particles and the simulation, fabrication and testing of the tapered profile. This study revealed an outstanding performance with the capability of producing two regions of high electric field intensity at the bottom and top edges of the side wall of tapered microelectrodes. Observations on particle separation mainly by the lateral attraction force of particles with positive DEP on the y-axis and vertical repulsion force of particles with negative DEP on the z-axis proved an efficient and uniform FDEP produced by tapered electrodes. In conclusion, this study confirmed the reliability and efficiency of the tapered DEP microelectrodes in the process of selective detection and rapid manipulation at a higher efficiency rate than straight-cut microelectrodes, which is significant in DEP technology applications. Full article
(This article belongs to the Special Issue Advances in Lab-on-Chip Devices II)
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