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Biosensors
Special Issues
Micro/Nanomaterials for Diagnostic Biosensing Systems
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Micro/Nanomaterials for Diagnostic Biosensing Systems

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (20 April 2022) | Viewed by 13656

Special Issue Editors

Prof. Dr. Zhiqiang Su

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Guest Editor
College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Interests: nanohybrids; hydrogels; biomedical materials; biosensors; and bioelectronics
Special Issues, Collections and Topics in MDPI journals
Dr. Eithne Dempsey

E-Mail Website
Guest Editor
Department of Chemistry, Maynooth University, W23 F2K8 Co. Kildare, Ireland
Interests: nano and microsensors for rapid testing; electroanalysis applied to environmental and diagnostics (human and animal healthcare); forensic analysis
Dr. Xiaoyuan Zhang

E-Mail
Guest Editor
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Interests: biomolecules/materials interactions; nanomaterials engineering; nanotechnology; nanohybrids, structural and functional design; implantable and wearable biomaterials; biosensors

Special Issue Information

Dear Colleagues,

Biosensors consist of biological components with physical and chemical transducer devices. The investigation on biosensors is an emerging and developing research field. The related research areas include enzyme sensors, microbial sensors, cellular sensors, immune sensors, and virus detection, etc. Biosensors have extremely broad applications, such as life science research, disease diagnosis and monitoring, and environmental quality monitoring, etc.  Among various biosensors, more and more researchers found that biomolecules-integrated biosensors have even superior properties, such as excellent biocompatibility and better application stability. Besides, this kind of biosensors has the potential for multiple functional modulation, predictable structural design, controlled high-throughput analysis.

Authors are welcome to submit research articles, communications, reviews, and perspectives focused on fabrication strategies for micro/nanomaterials, synthesis of biomolecules-integrated materials, wearable and portable biosensors, in vivo/in vivo analysis, real-time detection, and single cell monitoring, etc. In addition, this special issue welcomes innovative papers, such as directions of programming and designing biosensor devices in conjunction with concepts such as big data.

Prof. Dr. Zhiqiang Su
Dr. Eithne Dempsey
Dr. Xiaoyuan Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Fabrication strategies for micro/nanomaterials
  • Biomolecules-integrated materials
  • Wearable and portable biosensors
  • Enzyme sensors
  • Immune sensors
  • DNA/RNA sensors
  • Microbial sensors
  • Virus detection
  • Point-of-care testing (POCT)
  • In vivo analysis of biosensors
  • In vitro analysis of biosensors
  • Real-time analysis of biosensors
  • Single-cell monitoring
  • Biosensing systems
  • Diagnostic platforms
  • Diagnostic programming

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Published Papers (4 papers)

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Research

10 pages, 1824 KiB  
Communication
Self-Assembly of Nanodiamonds and Plasmonic Nanoparticles for Nanoscopy
by Lukas Schmidheini, Raphael F. Tiefenauer, Volker Gatterdam, Andreas Frutiger, Takumi Sannomiya and Morteza Aramesh
Biosensors 2022, 12(3), 148; https://doi.org/10.3390/bios12030148 - 28 Feb 2022
Cited by 7 | Viewed by 3773
Abstract
Nanodiamonds have emerged as promising agents for sensing and imaging due to their exceptional photostability and sensitivity to the local nanoscale environment. Here, we introduce a hybrid system composed of a nanodiamond containing nitrogen-vacancy center that is paired to a gold nanoparticle via [...] Read more.
Nanodiamonds have emerged as promising agents for sensing and imaging due to their exceptional photostability and sensitivity to the local nanoscale environment. Here, we introduce a hybrid system composed of a nanodiamond containing nitrogen-vacancy center that is paired to a gold nanoparticle via DNA hybridization. Using multiphoton optical studies, we demonstrate that the harmonic mode emission generated in gold nanoparticles induces a coupled fluorescence emission in nanodiamonds. We show that the flickering of harmonic emission in gold nanoparticles directly influences the nanodiamonds’ emissions, resulting in stochastic blinking. By utilizing the stochastic emission fluctuations, we present a proof-of-principle experiment to demonstrate the potential application of the hybrid system for super-resolution microscopy. The introduced system may find applications in intracellular biosensing and bioimaging due to the DNA-based coupling mechanism and also the attractive characteristics of harmonic generation, such as low power, low background and tissue transparency. Full article
(This article belongs to the Special Issue Micro/Nanomaterials for Diagnostic Biosensing Systems)
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11 pages, 3227 KiB  
Article
MoS2 QDs/8-Armed Poly(Ethylene Glycol) Fluorescence Sensor for Three Nitrotoluenes (TNT) Detection
by Xiaoyuan Zhang and Zhiqiang Su
Biosensors 2021, 11(12), 475; https://doi.org/10.3390/bios11120475 - 25 Nov 2021
Cited by 2 | Viewed by 2174
Abstract
In this work, ammonia cross-linked 8-armed polyethylene glycol hydrogel material was successfully synthesized and used as a template for synthesizing nanoparticles with fluorescent properties. The 8-armed polyethylene glycol hydrogel template was used to prepare molybdenum disulfide quantum dots (MoS2 QDs). The ammonium [...] Read more.
In this work, ammonia cross-linked 8-armed polyethylene glycol hydrogel material was successfully synthesized and used as a template for synthesizing nanoparticles with fluorescent properties. The 8-armed polyethylene glycol hydrogel template was used to prepare molybdenum disulfide quantum dots (MoS2 QDs). The ammonium tetrathiomolybdate functioned as a molybdenum source and hydrazine hydrate functioned as a reducing agent. The fluorescence properties of the as-prepared MoS2 QDs were investigated. The bursting of fluorescence caused by adding different concentrations of explosive TNT was studied. The study indicated that the synthesized MoS2 QDs can be used for trace TNT detection with a detection limit of 6 nmol/L and a detection range of 16–700 nmol/L. Furthermore, it indicated that the fluorescence-bursting mechanism is static bursting. Full article
(This article belongs to the Special Issue Micro/Nanomaterials for Diagnostic Biosensing Systems)
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12 pages, 4266 KiB  
Article
Fabrication of Co3O4/NiCo2O4 Nanocomposite for Detection of H2O2 and Dopamine
by Tianjiao Liu, Xiaoyuan Zhang, Kun Fu, Nan Zhou, Jinping Xiong and Zhiqiang Su
Biosensors 2021, 11(11), 452; https://doi.org/10.3390/bios11110452 - 13 Nov 2021
Cited by 18 | Viewed by 3478
Abstract
Herein, the Co3O4/NiCo2O4 nanocomposite has been prepared as a novel electrochemical sensor to accurately detect hydrogen peroxide (H2O2) and glucose. ZIF-67 is a metal-organic framework (MOF) with Co as the center metal [...] Read more.
Herein, the Co3O4/NiCo2O4 nanocomposite has been prepared as a novel electrochemical sensor to accurately detect hydrogen peroxide (H2O2) and glucose. ZIF-67 is a metal-organic framework (MOF) with Co as the center metal ion. Co3O4 can be obtained by calcination of ZIF-67 at 700 °C, which can retain the structure of ZIF-67. The hollow Co3O4 nanocrystal was synthesized based on a calcination process of ZIF-67. This open structure can promote the whole Co3O4/NiCo2O4 nanocomposite larger accessible surface area and reactive sites. Co3O4 has good electrocatalytic performance, which has been applied in many fields. Moreover, H2O2 and dopamine sensing tests indicate that the as-prepared non-enzymatic electrochemical biosensor has good detection properties. The testing results indicate the as-prepared biosensor has a wide detection range, low detection limit, high selectivity, and long-term stability. These testing results suggest the potential application in food security, biomedicine, environmental detection, and pharmaceutical analysis. Full article
(This article belongs to the Special Issue Micro/Nanomaterials for Diagnostic Biosensing Systems)
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22 pages, 7097 KiB  
Article
An Electrochemical Evaluation of Novel Ferrocene Derivatives for Glutamate and Liver Biomarker Biosensing
by Geok Hong Soon, Mary Deasy and Eithne Dempsey
Biosensors 2021, 11(8), 254; https://doi.org/10.3390/bios11080254 - 28 Jul 2021
Cited by 3 | Viewed by 3368
Abstract
Here, we present an evaluation of two new monosubstituted ferrocene (Fc) derivatives, 3-(1H-pyrrol-1-yl)propanamidoferrocene and 1-hydroxy-2-[2-(thiophen-3-yl)-ethylamino]ethylferrocene, as glutamate oxidase mediators, together with their preparation and characterisation. Taking into consideration the influence of the electronic effects of substituents on the redox potentials of the Fc [...] Read more.
Here, we present an evaluation of two new monosubstituted ferrocene (Fc) derivatives, 3-(1H-pyrrol-1-yl)propanamidoferrocene and 1-hydroxy-2-[2-(thiophen-3-yl)-ethylamino]ethylferrocene, as glutamate oxidase mediators, together with their preparation and characterisation. Taking into consideration the influence of the electronic effects of substituents on the redox potentials of the Fc species, two candidates with pyrrole or thiophene moieties were proposed for investigation. Film studies involved potential sweeping in the presence of pyrrole or 3,4-ethylenedioxythiophene monomers resulting in stable electroactive films with % signal loss upon cycling ranging from 1 to 7.82% and surface coverage (Γ) 0.47–1.15 × 10−9 mol/cm2 for films formed under optimal conditions. Construction of a glutamate oxidase modified electrode resulted in second-generation biosensing with the aid of both cyclic voltammetry and hydrodynamic amperometry, resulting in glutamate sensitivity of 0.86–1.28 μA/mM and Km (app) values over the range 3.67–5.01 mM. A follow-up enzyme assay for liver biomarker γ-glutamyl transpeptidase realised unmediated and mediated measurement establishing reaction and incubation time investigations and a realising response over <100 U/L γ-glutamyl transpeptidase with a sensitivity of 5 nA/UL−1. Full article
(This article belongs to the Special Issue Micro/Nanomaterials for Diagnostic Biosensing Systems)
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