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Biosensors
Special Issues
Advances in Plasmonic and Nanoplasmonic Biosensors and Their Applications
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Advances in Plasmonic and Nanoplasmonic Biosensors and Their Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (20 January 2022) | Viewed by 12309

Special Issue Editor

Dr. Maria Carmen Estévez Alberola

E-Mail Website
Guest Editor
Nanobiosensors and Bioanalytical Applications Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, CIBER-BBN and BIST, Campus UAB Bellaterra, 08193 Barcelona, Spain
Interests: nanoplasmonics biosensors; nanophotonic biosensors; biofunctionalization strategies; clinical diagnosis; point-of-care devices; lab-on-a-chip; nanotechnology; nanomedicine; multiplexed analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The impact of plasmonics in the field of biosensing is enormous and in constant evolution. The introduction of new nanostructures into sensor chips that enhance the final sensitivity, the integration of compact, miniaturized sensing prototypes, and the expansion of multiplexed analysis can help boost the implementation of these devices in real-world settings. Merging such improvements with relevant biosensing applications also requires the use of appropiate customized biofunctionalization protocols that enable real samples to be analyzed with sufficient reproducibility and reliability.

The aim of this Special Issue is to highlight novel plasmonic biosensing configurations that can enhance the performance of these devices and enable their full application in biosensing. This may include the design and fabrication of new nanostructures with plasmonic properties, novel sensing arrangements that can boost their integration in lab-on-a-chip designs, and the demonstration of their potential with relevant, fully developed applications in, but not limited to, disease diagnostics, therapy monitoring, pollutant analysis, pathogen detection, and food safety. We also welcome articles on topics related to the incorporation of novel bioreceptors that enable sensitive, specific, and selective detection, the exploration of new biofunctionalization strategies that provide robust and stable receptor-modified sensor plasmonic chips, or the incorporation of multiplexed analyte detection.

Dr. Maria Carmen Estévez Alberola
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metallic nanostructures
  • nanofabrication
  • integrated plasmonic prototypes
  • point-of-care designs
  • surface plasmon resonance (SPR)
  • localized surface plasmon resonance (LSPR)
  • real sample analysis
  • assay validation
  • biofunctionalization strategies
  • multi-analyte detection

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Published Papers (3 papers)

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13 pages, 37631 KiB  
Article
Label-Free LSPR-Vertical Microcavity Biosensor for On-Site SARS-CoV-2 Detection
by Yuqiao Zheng, Sumin Bian, Jiacheng Sun, Liaoyong Wen, Guoguang Rong and Mohamad Sawan
Biosensors 2022, 12(3), 151; https://doi.org/10.3390/bios12030151 - 28 Feb 2022
Cited by 26 | Viewed by 4094
Abstract
Cost-effective, rapid, and sensitive detection of SARS-CoV-2, in high-throughput, is crucial in controlling the COVID-19 epidemic. In this study, we proposed a vertical microcavity and localized surface plasmon resonance hybrid biosensor for SARS-CoV-2 detection in artificial saliva and assessed its efficacy. The proposed [...] Read more.
Cost-effective, rapid, and sensitive detection of SARS-CoV-2, in high-throughput, is crucial in controlling the COVID-19 epidemic. In this study, we proposed a vertical microcavity and localized surface plasmon resonance hybrid biosensor for SARS-CoV-2 detection in artificial saliva and assessed its efficacy. The proposed biosensor monitors the valley shifts in the reflectance spectrum, as induced by changes in the refractive index within the proximity of the sensor surface. A low-cost and fast method was developed to form nanoporous gold (NPG) with different surface morphologies on the vertical microcavity wafer, followed by immobilization with the SARS-CoV-2 antibody for capturing the virus. Modeling and simulation were conducted to optimize the microcavity structure and the NPG parameters. Simulation results revealed that NPG-deposited sensors performed better in resonance quality and in sensitivity compared to gold-deposited and pure microcavity sensors. The experiment confirmed the effect of NPG surface morphology on the biosensor sensitivity as demonstrated by simulation. Pre-clinical validation revealed that 40% porosity led to the highest sensitivity for SARS-CoV-2 pseudovirus at 319 copies/mL in artificial saliva. The proposed automatic biosensing system delivered the results of 100 samples within 30 min, demonstrating its potential for on-site coronavirus detection with sufficient sensitivity. Full article
(This article belongs to the Special Issue Advances in Plasmonic and Nanoplasmonic Biosensors and Their Applications)
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14 pages, 3575 KiB  
Article
FDTD Analysis of Hotspot-Enabling Hybrid Nanohole-Nanoparticle Structures for SERS Detection
by Juan Gomez-Cruz, Yazan Bdour, Kevin Stamplecoskie and Carlos Escobedo
Biosensors 2022, 12(2), 128; https://doi.org/10.3390/bios12020128 - 17 Feb 2022
Cited by 16 | Viewed by 4267
Abstract
Metallic nanoparticles (MNPs) and metallic nanostructures are both commonly used, independently, as SERS substrates due to their enhanced plasmonic activity. In this work, we introduce and investigate a hybrid nanostructure with strong SERS activity that benefits from the collective plasmonic response of the [...] Read more.
Metallic nanoparticles (MNPs) and metallic nanostructures are both commonly used, independently, as SERS substrates due to their enhanced plasmonic activity. In this work, we introduce and investigate a hybrid nanostructure with strong SERS activity that benefits from the collective plasmonic response of the combination of MNPs and flow-through nanohole arrays (NHAs). The electric field distribution and electromagnetic enhancement factor of hybrid structures composed of silver NPs on both silver and gold NHAs are investigated via finite-difference time-domain (FDTD) analyses. This computational approach is used to find optimal spatial configurations of the nanoparticle positions relative to the nanoapertures and investigate the difference between Ag-NP-on-Ag-NHAs and Ag-NP-on-Au-NHAs hybrid structures. A maximum GSERS value of 6.8 × 109 is achieved with the all-silver structure when the NP is located 0.5 nm away from the rim of the NHA, while the maximum of 4.7 × 1010 is obtained when the nanoparticle is in full contact with the NHA for the gold-silver hybrid structure. These results demonstrate that the hybrid nanostructures enable hotspot formation with strong SERS activity and plasmonic enhancement compatible with SERS-based sensing applications. Full article
(This article belongs to the Special Issue Advances in Plasmonic and Nanoplasmonic Biosensors and Their Applications)
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10 pages, 4541 KiB  
Article
Detection of Exosomes Using Total Internal Reflected Imaging Ellipsometry
by Haoyu Liu, Wei Liu and Gang Jin
Biosensors 2021, 11(5), 164; https://doi.org/10.3390/bios11050164 - 20 May 2021
Cited by 6 | Viewed by 2939
Abstract
Exosomes are a kind of membrane-bound phospholipid nanovesicle that are secreted extensively in a variety of biological fluids. Accumulating evidence has indicated that exosomes not only communicate with cells, but also perform functional roles in physiology and pathology. In addition, exosomes have also [...] Read more.
Exosomes are a kind of membrane-bound phospholipid nanovesicle that are secreted extensively in a variety of biological fluids. Accumulating evidence has indicated that exosomes not only communicate with cells, but also perform functional roles in physiology and pathology. In addition, exosomes have also elicited a great deal of excitement due to their potential as disease biomarkers. Therefore, requirements for sensitive methods capable of precisely and specifically determining exosomes were needed. Herein, we not only develop a sensing surface to capture exosomes but also compare two surface proteins on exosomes, which are appropriate for detecting exosome surface markers by total internal reflected imaging ellipsometry (TIRIE). Protein G and antibody were immobilized on a thin layer of golden substrate to form the biosensing surface. The bio-interaction between antibodies and exosomes was recorded by the TIRIE in real time. The distance between exosomes adhered on a surface was 44 nm ± 0.5 nm. The KD  of anti-CD9 and exosome was lower than anti-CD63 and exosome by introducing pseudo-first-order interaction kinetics, which suggested that CD9 is more suitable for exosome surface markers than CD63. The limit of detection (LOD) of TIRIE was 0.4 μg/mL. In conclusion, we have proposed a surface for the detection of exosomes based on TIRIE, which can make the detection of exosomes convenient and efficient. Full article
(This article belongs to the Special Issue Advances in Plasmonic and Nanoplasmonic Biosensors and Their Applications)
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