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Biosensors
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Biosensors for Body Fluid Analysis II
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Biosensors for Body Fluid Analysis II

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 7499

Special Issue Editor

Dr. Esther Serrano-Pertierra

E-Mail Website
Guest Editor
Department of Analytical and Physical Chemistry, University of Oviedo, Oviedo, Spain
Interests: extracellular vesicles; enrichment; ultracentrifugation; nanoparticle tracking analysis; lateral flow immunoassay
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to introduce this Special Issue focused on biosensors for the analysis of different body fluids.

Biosensors are becoming an important avenue of biomedical research. From a simple thermometer to detect changes in body temperature, to the development of the first glucometer in 1962, these fascinating devices have gradually been incorporated into clinical practice.

Biosensors are generally small, fast, selective, sensitive, and easy-to-use devices. Their use may speed up test results, allowing early clinical decisions to be taken and benefitting the patient. A person’s health status can be continuously monitored (e.g., blood oxygen monitors). Other biosensors are so common that they are used at home, such as pregnancy test or the aforementioned glucometers.

In places where health facilities are not easily accessible, the introduction of rapid tests becomes even more relevant. Simple tests to detect infectious diseases such as HIV or HVC can make a great difference. In addition, coupling new technologies to biosensors would make health tests more affordable and portable.

In this Special Issue, we aim to gather the most recent research in the field of biosensors that may directly be applied to biofluids (saliva, urine, synovial fluid, cerebrospinal fluid, etc.) without sample pretreatment.

Dr. Esther Serrano-Pertierra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • body fluids
  • point of care
  • saliva
  • cerebrospinal fluid
  • plasma
  • serum
  • urine
  • synovial fluid

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Published Papers (2 papers)

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Research

16 pages, 4330 KiB  
Article
Electrochemical Sensing of Urinary Chloride Ion Concentration for Near Real-Time Monitoring
by Anna M. Nelson, Sanaz Habibi, John O. L. DeLancey, James A. Ashton-Miller and Mark A. Burns
Biosensors 2023, 13(3), 331; https://doi.org/10.3390/bios13030331 - 28 Feb 2023
Cited by 3 | Viewed by 2651
Abstract
Urinary chloride concentration is a valuable health metric that can aid in the early detection of serious conditions, such as acid base disorders, acute heart failure, and incidences of acute renal failure in the intensive care unit. Physiologically, urinary chloride levels frequently change [...] Read more.
Urinary chloride concentration is a valuable health metric that can aid in the early detection of serious conditions, such as acid base disorders, acute heart failure, and incidences of acute renal failure in the intensive care unit. Physiologically, urinary chloride levels frequently change and are difficult to measure, involving time-consuming and inconvenient lab testing. Thus, near real-time simple sensors are needed to quickly provide actionable data to inform diagnostic and treatment decisions that affect health outcomes. Here, we introduce a chronopotentiometric sensor that utilizes commercially available screen-printed electrodes to accurately quantify clinically relevant chloride concentrations (5–250 mM) in seconds, with no added reagents or electrode surface modification. Initially, the sensor’s performance was optimized through the proper selection of current density at a specific chloride concentration, using electrical response data in conjunction with scanning electron microscopy. We developed a unique swept current density algorithm to resolve the entire clinically relevant chloride concentration range, and the chloride sensors can be reliably reused for chloride concentrations less than 50 mM. Lastly, we explored the impact of pH, temperature, conductivity, and additional ions (i.e., artificial urine) on the sensor signal, in order to determine sensor feasibility in complex biological samples. This study provides a path for further development of a portable, near real-time sensor for the quantification of urinary chloride. Full article
(This article belongs to the Special Issue Biosensors for Body Fluid Analysis II)
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11 pages, 4250 KiB  
Communication
Colorimetric Sensing of Lactate in Human Sweat Using Polyaniline Nanoparticles-Based Sensor Platform and Colorimeter
by Hyun Jung Kim, Insu Park, Seung Pil Pack, Gyudo Lee and Yoochan Hong
Biosensors 2022, 12(4), 248; https://doi.org/10.3390/bios12040248 - 15 Apr 2022
Cited by 17 | Viewed by 3746
Abstract
In emergency medicine, the lactate level is commonly used as an indicator of the severity and response to the treatment of hypoperfusion-related diseases. Clinical lactate measurements generally require 3 h for clinical determination. To improve the current gold standard methods, the development of [...] Read more.
In emergency medicine, the lactate level is commonly used as an indicator of the severity and response to the treatment of hypoperfusion-related diseases. Clinical lactate measurements generally require 3 h for clinical determination. To improve the current gold standard methods, the development of sensor devices that can reduce detection time while maintaining sensitivity and providing portability is gaining great attention. This study aimed to develop a polyaniline (PAni)-based single-sensor platform for sensing lactate in human sweat using a CIELAB color system-based colorimetric device. To establish a lactate sensing platform, PAni nanoparticles were synthesized and adsorbed on the filter paper surface using solvent shift and dip-coating methods, respectively. PAni is characterized by a chemical change accompanied by a color change according to the surrounding environment. To quantify the color change of PAni, a CIELAB color system-based colorimetric device was fabricated. The color change of PAni was measured according to the chemical state using a combination of a PAni-based filter paper sensor platform and a colorimetric device, based on the lactate concentration in deionized water. Finally, human sweat was spiked with lactate to measure the color change of the PAni-based filter paper sensor platform. Under these conditions, the combination of polyaniline-based sensor platforms and colorimetric systems has a limit of detection (LOD) and limit of quantitation (LOQ) of 1 mM, linearity of 0.9684, and stability of 14%. Tbe confirmed that the color of the substrate changes after about 30 s, and through this, the physical fatigue of the individual can be determined. In conclusion, it was confirmed through this study that a combination of the PAni paper sensor platform and colorimeter can detect clinically meaningful lactate concentration. Full article
(This article belongs to the Special Issue Biosensors for Body Fluid Analysis II)
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