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Biosensors
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State-of-the-Art Biosensors in China
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State-of-the-Art Biosensors in China

A special issue of Biosensors (ISSN 2079-6374).

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 13209

Printed Edition Available!
A printed edition of this Special Issue is available here.

Special Issue Editor

Prof. Dr. Ping Yu

E-Mail Website
Guest Editor
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Interests: in vivo analysis; single entity analysis; ion transport at confince space; electroanalysis; bioelectrochemistry

Special Issue Information

Dear Colleagues,

We plan to publish a Special Issue entitled “State-of-the-Art Biosensors in China”, this regional project aiming to collect high-quality research articles, comprehensive reviews, and communications regarding all aspects of biosensors and biosensing from China. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible, including, but not limited to, the following topic themes:

  • DNA/RNA chips;
  • DNA/RNA sensors;
  • Enzyme‐based sensors;
  • Lab-on-a-chip technology;
  • Micro/nanofluidic devices;
  • Immunosensors;
  • Biomaterials;
  • Real-time and in situ assay based on biosensors technology;
  • Label-free biosensors;
  • In vivo and in vitro analysis;
  • Electroanalysis;
  • Bioelectrochemistry;
  • Nanopore sensors.

Prof. Dr. Ping Yu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

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Research

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11 pages, 3620 KiB  
Article
Biosensor Based on Covalent Organic Framework Immobilized Acetylcholinesterase for Ratiometric Detection of Carbaryl
by Ying Luo, Na Wu, Linyu Wang, Yonghai Song, Yan Du and Guangran Ma
Biosensors 2022, 12(8), 625; https://doi.org/10.3390/bios12080625 - 10 Aug 2022
Cited by 9 | Viewed by 2328
Abstract
A ratiometric electrochemical biosensor based on a covalent organic framework (COFThi-TFPB) loaded with acetylcholinesterase (AChE) was developed. First, an electroactive COFThi-TFPB with a two-dimensional sheet structure, positive charge and a pair of inert redox peaks was synthesized via a dehydration [...] Read more.
A ratiometric electrochemical biosensor based on a covalent organic framework (COFThi-TFPB) loaded with acetylcholinesterase (AChE) was developed. First, an electroactive COFThi-TFPB with a two-dimensional sheet structure, positive charge and a pair of inert redox peaks was synthesized via a dehydration condensation reaction between positively charged thionine (Thi) and 1,3,5-triformylphenylbenzene (TFPB). The immobilization of AChE on the positively charged electrode surface was beneficial for maintaining its bioactivity and achieving the best catalytic effect; therefore, the positively charged COFThi-TFPB was an appropriate support material for AChE. Furthermore, the COFThi-TFPB provided a stable internal reference signal for the constructed AChE inhibition-based electrochemical biosensor to eliminate various effects which were unrelated to the detection of carbaryl. The sensor had a linear range of 2.2–60 μM with a detection limit of 0.22 μM, and exhibited satisfactory reproducibility, stability and anti-interference ability for the detection of carbaryl. This work offers a possibility for the application of COF-based materials in the detection of low-level pesticide residues. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors in China)
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9 pages, 2517 KiB  
Article
Label-Free and Homogeneous Electrochemical Biosensor for Flap Endonuclease 1 Based on the Target-Triggered Difference in Electrostatic Interaction between Molecular Indicators and Electrode Surface
by Jianping Zheng, Xiaolin Xu, Hanning Zhu, Zhipeng Pan, Xianghui Li, Fang Luo and Zhenyu Lin
Biosensors 2022, 12(7), 528; https://doi.org/10.3390/bios12070528 - 15 Jul 2022
Cited by 4 | Viewed by 2092
Abstract
Target-induced differences in the electrostatic interactions between methylene blue (MB) and indium tin oxide (ITO) electrode surface was firstly employed to develop a homogeneous electrochemical biosensor for flap endonuclease 1 (FEN1) detection. In the absence of FEN1, the positively charged methylene blue (MB) [...] Read more.
Target-induced differences in the electrostatic interactions between methylene blue (MB) and indium tin oxide (ITO) electrode surface was firstly employed to develop a homogeneous electrochemical biosensor for flap endonuclease 1 (FEN1) detection. In the absence of FEN1, the positively charged methylene blue (MB) is free in the solution and can diffuse onto the negatively charged ITO electrode surface easily, resulting in an obvious electrochemical signal. Conversely, with the presence of FEN1, a 5′-flap is cleaved from the well-designed flapped dumbbell DNA probe (FDP). The remained DNA fragment forms a closed dumbbell DNA probe to trigger hyperbranched rolling circle amplification (HRCA) reaction, generating plentiful dsDNA sequences. A large amount of MB could be inserted into the produced dsDNA sequences to form MB-dsDNA complexes, which contain a large number of negative charges. Due to the strong electrostatic repulsion between MB-dsDNA complexes and the ITO electrode surface, a significant signal drop occurs. The signal change (ΔCurrent) shows a linear relationship with the logarithm of FEN1 concentration from 0.04 to 80.0 U/L with a low detection limit of 0.003 U/L (S/N = 3). This study provides a label-free and homogeneous electrochemical platform for evaluating FEN1 activity. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors in China)
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12 pages, 2779 KiB  
Article
Selective Detection of Alkaline Phosphatase Activity in Environmental Water Samples by Copper Nanoclusters Doped Lanthanide Coordination Polymer Nanocomposites as the Ratiometric Fluorescent Probe
by Xin Li, Xiaoling Wang, Wei Guo, Yunfei Wang, Qing Hua, Feiyan Tang, Feng Luan, Chunyuan Tian, Xuming Zhuang and Lijun Zhao
Biosensors 2022, 12(6), 372; https://doi.org/10.3390/bios12060372 - 28 May 2022
Cited by 6 | Viewed by 2384
Abstract
In this paper, a novel, accurate, sensitive and rapid ratiometric fluorescent sensor was fabricated using a copper nanoclusters@infinite coordination polymer (ICP), specifically, terbium ion-guanosine 5’-disodium (Cu NCs@Tb-GMP) nanocomposites as the ratiometric fluorescent probe, to detect alkaline phosphatase (ALP) in water. The fluorescence probe [...] Read more.
In this paper, a novel, accurate, sensitive and rapid ratiometric fluorescent sensor was fabricated using a copper nanoclusters@infinite coordination polymer (ICP), specifically, terbium ion-guanosine 5’-disodium (Cu NCs@Tb-GMP) nanocomposites as the ratiometric fluorescent probe, to detect alkaline phosphatase (ALP) in water. The fluorescence probe was characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy. The experimental results showed that, compared with Tb-GMP fluorescent sensors, Cu ratiometric fluorescent sensors based on NCs encapsulated in Tb-GMP had fewer experimental errors and fewer false-positive signals and were more conducive to the sensitive and accurate detection of ALP. In addition, the developed fluorescent probe had good fluorescence intensity, selectivity, repeatability and stability. Under optimized conditions, the ratiometric fluorescent sensor detected ALP in the range of 0.002–2 U mL−1 (R2 = 0.9950) with a limit of detection of 0.002 U mL−1, and the recovery of ALP from water samples was less than 108.2%. These satisfying results proved that the ratiometric fluorescent probe has good application prospects and provides a new method for the detection of ALP in real water samples. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors in China)
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Review

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18 pages, 5181 KiB  
Review
Progress in Probe-Based Sensing Techniques for In Vivo Diagnosis
by Cheng Zhou, Zecai Lin, Shaoping Huang, Bing Li and Anzhu Gao
Biosensors 2022, 12(11), 943; https://doi.org/10.3390/bios12110943 - 31 Oct 2022
Cited by 4 | Viewed by 2515
Abstract
Advancements in robotic surgery help to improve the endoluminal diagnosis and treatment with minimally invasive or non-invasive intervention in a precise and safe manner. Miniaturized probe-based sensors can be used to obtain information about endoluminal anatomy, and they can be integrated with medical [...] Read more.
Advancements in robotic surgery help to improve the endoluminal diagnosis and treatment with minimally invasive or non-invasive intervention in a precise and safe manner. Miniaturized probe-based sensors can be used to obtain information about endoluminal anatomy, and they can be integrated with medical robots to augment the convenience of robotic operations. The tremendous benefit of having this physiological information during the intervention has led to the development of a variety of in vivo sensing technologies over the past decades. In this paper, we review the probe-based sensing techniques for the in vivo physical and biochemical sensing in China in recent years, especially on in vivo force sensing, temperature sensing, optical coherence tomography/photoacoustic/ultrasound imaging, chemical sensing, and biomarker sensing. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors in China)
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21 pages, 3275 KiB  
Review
Progress and Prospects of Electrochemiluminescence Biosensors Based on Porous Nanomaterials
by Chenchen Li, Jinghui Yang, Rui Xu, Huan Wang, Yong Zhang and Qin Wei
Biosensors 2022, 12(7), 508; https://doi.org/10.3390/bios12070508 - 11 Jul 2022
Cited by 13 | Viewed by 3083
Abstract
Porous nanomaterials have attracted much attention in the field of electrochemiluminescence (ECL) analysis research because of their large specific surface area, high porosity, possession of multiple functional groups, and ease of modification. Porous nanomaterials can not only serve as good carriers for loading [...] Read more.
Porous nanomaterials have attracted much attention in the field of electrochemiluminescence (ECL) analysis research because of their large specific surface area, high porosity, possession of multiple functional groups, and ease of modification. Porous nanomaterials can not only serve as good carriers for loading ECL luminophores to prepare nanomaterials with excellent luminescence properties, but they also have a good electrical conductivity to facilitate charge transfer and substance exchange between electrode surfaces and solutions. In particular, some porous nanomaterials with special functional groups or centered on metals even possess excellent catalytic properties that can enhance the ECL response of the system. ECL composites prepared based on porous nanomaterials have a wide range of applications in the field of ECL biosensors due to their extraordinary ECL response. In this paper, we reviewed recent research advances in various porous nanomaterials commonly used to fabricate ECL biosensors, such as ordered mesoporous silica (OMS), metal–organic frameworks (MOFs), covalent organic frameworks (COFs) and metal–polydopamine frameworks (MPFs). Their applications in the detection of heavy metal ions, small molecules, proteins and nucleic acids are also summarized. The challenges and prospects of constructing ECL biosensors based on porous nanomaterials are further discussed. We hope that this review will provide the reader with a comprehensive understanding of the development of porous nanomaterial-based ECL systems in analytical biosensors and materials science. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors in China)
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