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Biosensors
Special Issues
Nanomaterial-Based Biosensors for DNA and RNA Detection
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Nanomaterial-Based Biosensors for DNA and RNA Detection

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 14966

Special Issue Editors

Dr. Jin-Ha Choi

E-Mail Website
Guest Editor
School of Chemical Engineering, Jeonbuk National University, Jeonju 54896, Republic of Korea
Interests: nanobiosensor; plasmonic nanomaterials; early diagnosis; CRISPR biosensor; nanotheragnosis
Special Issues, Collections and Topics in MDPI journals
Dr. Hyeon-Yeol Cho

E-Mail Website
Guest Editor
Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea
Interests: stem cell biology; nanobiomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The main topic of this Special Issue is nucleic acid biosensors constructed by integrating several nanomaterials. Biosensors are being actively used in various fields such as the medical, food, and environmental fields. For example, various nucleic acid biomarkers in body fluids have been discovered and utilized for the early diagnosis of numerous diseases. In particular, viral RNA detection systems have been developed and commercialized to minimize infection to other people and the fatality rate of infected patients. Multifunctional nanomaterials have been applied to biosensing systems to improve the performance of sensors, including sensitivity and selectivity. From this point of view, this Special Issue aims to gather original articles and reviews showing research advances, fabrication, innovative applications, new challenges, and future perspectives of nanomaterial-based biosensors for DNA and RNA detection in diverse areas such as the medical area. You are invited to participate in this project. Any contribution in this sense is welcome to this Special Issue.

If you would be interested in submitting a contribution or have any questions, please do not hesitate to get in touch with me.

Dr. Jin-Ha Choi
Dr. Hyun-Yeol Cho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • nanoparticles
  • DNA biosensor
  • RNA biosensor
  • optical biosensor
  • electrochemical biosensor
  • healthcare monitoring
  • environmental biosensor
  • food biosensor
  • viral biosensor

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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Review

17 pages, 2594 KiB  
Review
Aptameric Fluorescent Biosensors for Liver Cancer Diagnosis
by Seonga Park, Euni Cho, Sy-Tsong Dean Chueng, June-Sun Yoon, Taek Lee and Jin-Ho Lee
Biosensors 2023, 13(6), 617; https://doi.org/10.3390/bios13060617 - 4 Jun 2023
Cited by 8 | Viewed by 3561
Abstract
Liver cancer is a prevalent global health concern with a poor 5-year survival rate upon diagnosis. Current diagnostic techniques using the combination of ultrasound, CT scans, MRI, and biopsy have the limitation of detecting detectable liver cancer when the tumor has already progressed [...] Read more.
Liver cancer is a prevalent global health concern with a poor 5-year survival rate upon diagnosis. Current diagnostic techniques using the combination of ultrasound, CT scans, MRI, and biopsy have the limitation of detecting detectable liver cancer when the tumor has already progressed to a certain size, often leading to late-stage diagnoses and grim clinical treatment outcomes. To this end, there has been tremendous interest in developing highly sensitive and selective biosensors to analyze related cancer biomarkers in the early stage diagnosis and prescribe appropriate treatment options. Among the various approaches, aptamers are an ideal recognition element as they can specifically bind to target molecules with high affinity. Furthermore, using aptamers, in conjunction with fluorescent moieties, enables the development of highly sensitive biosensors by taking full advantage of structural and functional flexibility. This review will provide a summary and detailed discussion on recent aptamer-based fluorescence biosensors for liver cancer diagnosis. Specifically, the review focuses on two promising detection strategies: (i) Förster resonance energy transfer (FRET) and (ii) metal-enhanced fluorescence for detecting and characterizing protein and miRNA cancer biomarkers. Full article
(This article belongs to the Special Issue Nanomaterial-Based Biosensors for DNA and RNA Detection)
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16 pages, 2707 KiB  
Review
Recent Advances in Aptamer-Based Sensors for Sensitive Detection of Neurotransmitters
by Joon-Ha Park, Yun-Sik Eom and Tae-Hyung Kim
Biosensors 2023, 13(4), 413; https://doi.org/10.3390/bios13040413 - 23 Mar 2023
Cited by 6 | Viewed by 3587
Abstract
In recent years, there has been an increased demand for highly sensitive and selective biosensors for neurotransmitters, owing to advancements in science and technology. Real-time sensing is crucial for effective prevention of neurological and cardiovascular diseases. In this review, we summarise the latest [...] Read more.
In recent years, there has been an increased demand for highly sensitive and selective biosensors for neurotransmitters, owing to advancements in science and technology. Real-time sensing is crucial for effective prevention of neurological and cardiovascular diseases. In this review, we summarise the latest progress in aptamer-based biosensor technology, which offers the aforementioned advantages. Our focus is on various biomaterials utilised to ensure the optimal performance and high selectivity of aptamer-based biosensors. Overall, this review aims to further aptamer-based biosensor technology. Full article
(This article belongs to the Special Issue Nanomaterial-Based Biosensors for DNA and RNA Detection)
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Graphical abstract

24 pages, 5113 KiB  
Review
Nanotechnology-Assisted Biosensors for the Detection of Viral Nucleic Acids: An Overview
by Hye Kyu Choi and Jinho Yoon
Biosensors 2023, 13(2), 208; https://doi.org/10.3390/bios13020208 - 30 Jan 2023
Cited by 15 | Viewed by 4725
Abstract
The accurate and rapid diagnosis of viral diseases has garnered increasing attention in the field of biosensors. The development of highly sensitive, selective, and accessible biosensors is crucial for early disease detection and preventing mortality. However, developing biosensors optimized for viral disease diagnosis [...] Read more.
The accurate and rapid diagnosis of viral diseases has garnered increasing attention in the field of biosensors. The development of highly sensitive, selective, and accessible biosensors is crucial for early disease detection and preventing mortality. However, developing biosensors optimized for viral disease diagnosis has several limitations, including the accurate detection of mutations. For decades, nanotechnology has been applied in numerous biological fields such as biosensors, bioelectronics, and regenerative medicine. Nanotechnology offers a promising strategy to address the current limitations of conventional viral nucleic acid-based biosensors. The implementation of nanotechnologies, such as functional nanomaterials, nanoplatform-fabrication techniques, and surface nanoengineering, to biosensors has not only improved the performance of biosensors but has also expanded the range of sensing targets. Therefore, a deep understanding of the combination of nanotechnologies and biosensors is required to prepare for sanitary emergencies such as the recent COVID-19 pandemic. In this review, we provide interdisciplinary information on nanotechnology-assisted biosensors. First, representative nanotechnologies for biosensors are discussed, after which this review summarizes various nanotechnology-assisted viral nucleic acid biosensors. Therefore, we expect that this review will provide a valuable basis for the development of novel viral nucleic acid biosensors. Full article
(This article belongs to the Special Issue Nanomaterial-Based Biosensors for DNA and RNA Detection)
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Figure 1

19 pages, 2037 KiB  
Review
Recent Development in Plasmonic Nanobiosensors for Viral DNA/RNA Biomarkers
by Dong Hyeok Park, Min Yu Choi and Jin-Ha Choi
Biosensors 2022, 12(12), 1121; https://doi.org/10.3390/bios12121121 - 3 Dec 2022
Cited by 10 | Viewed by 2449
Abstract
Recently, due to the coronavirus pandemic, the need for early diagnosis of infectious diseases, including viruses, is emerging. Though early diagnosis is essential to prevent infection and progression to severe illness, there are few technologies that accurately measure low concentrations of biomarkers. Plasmonic [...] Read more.
Recently, due to the coronavirus pandemic, the need for early diagnosis of infectious diseases, including viruses, is emerging. Though early diagnosis is essential to prevent infection and progression to severe illness, there are few technologies that accurately measure low concentrations of biomarkers. Plasmonic nanomaterials are attracting materials that can effectively amplify various signals, including fluorescence, Raman, and other optical and electromagnetic output. In this review, we introduce recently developed plasmonic nanobiosensors for measuring viral DNA/RNA as potential biomarkers of viral diseases. In addition, we discuss the future perspective of plasmonic nanobiosensors for DNA/RNA detection. This review is expected to help the early diagnosis and pathological interpretation of viruses and other diseases. Full article
(This article belongs to the Special Issue Nanomaterial-Based Biosensors for DNA and RNA Detection)
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