Organic Bioelectronic Materials and Devices for In Vitro/Vivo Diagnostics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 7717

Special Issue Editors

Center for Sensors and Devices, Bruno Kessler Foundation (FBK), 38123 Trento, Italy
Interests: organic bioelectronics; organic fied-effect transistors; device physics; semiconductor devices; thin-film processing; micro/nano-fabrication
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Guest Editor
Research Center for Materials, Architectures and Integration of Nanomembranes, Chemnitz University of Technology, 09126 Chemnitz, Germany
Interests: intelligent materials; bioelectronics; OMIECs; charge transport mechanisms
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Guest Editor
Science Exploration Team, Gwacheon National Science Museum, Gwacheon-si 13817, Gyeonggi-do, Korea
Interests: organic semiconductors; organic electronic devices; organic bioelectronics; organic neuromorphic devices

Special Issue Information

Dear Colleagues,

Organic bioelectronics constitute the development and investigation of organic electronic devices that translate biological signals into an electronic readout. On one hand, organic bioelectronics allows us to regulate the physiology and processes of cells, tissues, and organs, and on the other hand, it can also be applied for selective sensing, recording, and monitoring of various signals and physiological states.

In order to bridge the interface between biology and electronics, an important aspect involves the advancement of materials, which, in turn, enables better performing bioelectronic devices or entirely new device concepts. The existing bioelectronic devices mostly compose of conventional materials, such as metals, that do not exhibit intrinsic compatibility with biological systems and are unable to convert biological ionic signals into electronic ones. The structural and functional similarity between organic and biological systems gives rise to many new applications in the areas spanning from neural interfacing and drug delivery to tissue engineering and diagnostics. Among other unique features, organic materials and devices offer "soft" mechanical properties, mixed electronic/ionic conductivity for efficient signal transduction, facile functionalization for the detection of biological analytes, and economical synthesis. All of the aforementioned aspects, in addition to better biocompatibility and biodegradability, make organic systems more suitable for biomedical applications.

This Special Issue aims to share new developments in the growing field of bioelectronics, as well as to understand new challenges that are being faced in this field. We invite authors to contribute articles that will stimulate the continuing efforts in this field, by developing novel bioelectronic materials or devices, or by optimizing the performance of already available technologies.

The topics of interest include, but are not limited to:

  • Materials for in vitro and in vivo organic bioelectronics;
  • Devices for in vitro and in vivo organic bioelectronics;
  • Tailoring biointerfaces for in vitro and in vivo applications;
  • Modeling in vitro and in vivo organic bioelectronics applications;
  • Cell-based interfacing for in vitro and in vivo organic bioelectronics;
  • Fluidic-integrated models for in vitro and in vivo organic bioelectronic systems.

Dr. Ali Nawaz
Dr. Leandro Merces
Dr. Hae Rang Lee
Guest Editors

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Keywords

  • bioelectronic devices
  • biosensing
  • materials
  • biointerfaces
  • neural interfacing
  • drug delivery
  • tissue engineering
  • diagnostics

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Published Papers (3 papers)

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Research

15 pages, 3159 KiB  
Article
PEDOT-Polyamine-Based Organic Electrochemical Transistors for Monitoring Protein Binding
by Marjorie Montero-Jimenez, Francisco L. Amante, Gonzalo E. Fenoy, Juliana Scotto, Omar Azzaroni and Waldemar A. Marmisolle
Biosensors 2023, 13(2), 288; https://doi.org/10.3390/bios13020288 - 17 Feb 2023
Cited by 5 | Viewed by 3017
Abstract
The fabrication of efficient organic electrochemical transistors (OECTs)-based biosensors requires the design of biocompatible interfaces for the immobilization of biorecognition elements, as well as the development of robust channel materials to enable the transduction of the biochemical event into a reliable electrical signal. [...] Read more.
The fabrication of efficient organic electrochemical transistors (OECTs)-based biosensors requires the design of biocompatible interfaces for the immobilization of biorecognition elements, as well as the development of robust channel materials to enable the transduction of the biochemical event into a reliable electrical signal. In this work, PEDOT-polyamine blends are shown as versatile organic films that can act as both highly conducting channels of the transistors and non-denaturing platforms for the construction of the biomolecular architectures that operate as sensing surfaces. To achieve this goal, we synthesized and characterized films of PEDOT and polyallylamine hydrochloride (PAH) and employed them as conducting channels in the construction of OECTs. Next, we studied the response of the obtained devices to protein adsorption, using glucose oxidase (GOx) as a model system, through two different strategies: The direct electrostatic adsorption of GOx on the PEDOT-PAH film and the specific recognition of the protein by a lectin attached to the surface. Firstly, we used surface plasmon resonance to monitor the adsorption of the proteins and the stability of the assemblies on PEDOT-PAH films. Then, we monitored the same processes with the OECT showing the capability of the device to perform the detection of the protein binding process in real time. In addition, the sensing mechanisms enabling the monitoring of the adsorption process with the OECTs for the two strategies are discussed. Full article
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13 pages, 2424 KiB  
Article
Sensitive and Rapid Detection of Aspartic Acid with Co3O4-ZnO Nanorods Using Differential Pulse Voltammetry
by Sulaiman Y. Alfaifi, Waheed Abiodun Adeosun, Abdullah M. Asiri and Mohammed M. Rahman
Biosensors 2023, 13(1), 88; https://doi.org/10.3390/bios13010088 - 5 Jan 2023
Cited by 7 | Viewed by 2238
Abstract
Herein, the detection of aspartic acid by doped Co3O4-ZnO nanorod materials was proposed using differential pulse voltammetry. The nano-composite metal oxide was synthesized by the wet precipitation method in basic media. Aspartic acid is a non-essential amino acid naturally [...] Read more.
Herein, the detection of aspartic acid by doped Co3O4-ZnO nanorod materials was proposed using differential pulse voltammetry. The nano-composite metal oxide was synthesized by the wet precipitation method in basic media. Aspartic acid is a non-essential amino acid naturally synthesized in the body with lot of health significance, including as a biomarker for several health deficiencies. The synthesized composite Co3O4-ZnO nanorod was well-investigated by using FESEM, XRD, XPS, FTIR, UV/vis., EIS, and CV. The synthesized composite exhibited a low limit of detection (0.03 µM, high sensitivity (0.0014 µA µM−1 cm−2) and wide linear range (0.05–50 µM) for aspartic acid. The substrate, the Co3O4-ZnO nanorod, enhanced the electro-catalytic oxidation of aspartic acid as a result of its catalytic and conductivity properties. The developed sensor based on Co3O4-ZnO has a repeatable, reproducible and stable current response for aspartic acid. Additionally, other electroactive compounds did not interfere with the sensor’s current response. The suitability of the developed sensor for real sample analysis was also established. Therefore, this study proposed the potential use of Co3O4-ZnO nanorod material in healthcare management for the maintenance of human well-being. Full article
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12 pages, 1698 KiB  
Article
Organic Light-Emitting Diode Based Fluorescence-Linked Immunosorbent Assay for SARS-CoV-2 Antibody Detection
by Cheng Lian, Dan Young, Richard E. Randall and Ifor D. W. Samuel
Biosensors 2022, 12(12), 1125; https://doi.org/10.3390/bios12121125 - 5 Dec 2022
Cited by 4 | Viewed by 1807
Abstract
Immunodiagnostics have been widely used in the detection of disease biomarkers. The conventional immunological tests in central laboratories require expensive equipment and, for non-specialists, the tests are technically demanding and time-consuming, which has prevented their use by the public. Thus, point-of-care tests (POCT), [...] Read more.
Immunodiagnostics have been widely used in the detection of disease biomarkers. The conventional immunological tests in central laboratories require expensive equipment and, for non-specialists, the tests are technically demanding and time-consuming, which has prevented their use by the public. Thus, point-of-care tests (POCT), such as lateral flow immunoassays, are being, or have been, developed as more convenient and low-cost methods for immunodiagnostics. However, the sensitivity of such tests is often a concern. Here, a fluorescence-linked immunosorbent assay (FLISA) using organic light-emitting diodes (OLEDs) as excitation light sources was investigated as a way forward for the development of compact and sensitive POCTs. Phycoerythrin (PE) was selected as the fluorescent dye, and OLEDs were designed with different emission spectra. The leakage light of different OLEDs for exciting PE was then investigated to reduce the background noise and improve the sensitivity of the system. Finally, as proof-of-principle that OLED-based technology can be successfully further developed for POCT, antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human serum was detected by OLED−FLISA. Full article
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