Mechanisms of Antimicrobial Treatment in Human Diseases
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 December 2024 | Viewed by 1354
Special Issue Editor
Interests: antimicrobial resistance; difficult-to-treat infections; multidrug-resistance; epidemiology; PK/PD
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antibiotics represent one of the most important discoveries of the last century, saving billion of lives following their introduction in clinical practice. Since the discovery of the first antimicrobial molecule, however, the emergence of antimicrobial resistance has been reported in several bacterial species. At the present, antimicrobial resistance represents a serious threat for public health, and infections due to multidrug-resistant (MDR) microorganisms represent one of the most important causes of death worldwide. In this context, the emergence and diffusion of MDR bacteria posed several limitations in the treatment of infections due to these microorganisms, thus requiring novel approaches to treat infections especially in critically ill patients. In recent years, the introduction of new antibiotics created the availability of new therapeutic strategies to treat infections sustained by microorganisms with a broad spectrum of resistance. At the same time, different points remain open for discussion regarding the optimal usage of new and old molecules, especially in the treatment of difficult-to-treat (DTR) infections caused by MDR bacteria. Although different steps have been taken in recent years, different questions remain unanswered regarding the optimal usage of different molecules and the correct pharmacokinetic/pharmacodynamic targets in clinical practice. In this Special Issue, we intend to focus on the appropriate use of antimicrobials with particular focus on the new molecules with action on MDR bacteria. We intend to collect original research articles, short communications, or review articles regarding the mechanisms of actions, the optimal administration of different antimicrobial molecules for the treatment of DTR due by MDR bacteria, and the emergence of new traits of resistance.
Dr. Paolo Gaibani
Guest Editor
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Keywords
- multidrug resistance
- epidemiology
- novel antimicrobial resistance traits
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