Protein Biology of the Aging Process

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".

Deadline for manuscript submissions: closed (25 July 2023) | Viewed by 3807

Special Issue Editors


E-Mail Website
Guest Editor
Division of Molecular and Cell Biology, National University of Singapore, Singapore 119260, Singapore
Interests: autophagy; cancer; Mitophagy

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Guest Editor
Health and Social Sciences Cluster, Singapore Institute of Technology, Singapore City, Singapore
Interests: aging; Alzheimer's disease; glucose metabolism; insulin signaling; apoe; prion protein

Special Issue Information

Dear Colleagues,

Aging is an inevitable part of our lifespan. This biological process is also a major risk factor for the development of many diseases, including Alzheimer’s disease and several cancer types. In many parts of the world, the population is aging rapidly. The socio-economic costs of managing this process and related diseases can be enormous. To better manage this challenge, it is important for us to better understand and regulate the aging process. Years of research have revealed several biological hallmarks of aging. Many of these are connected with metabolism and dysfunction in proteostasis. This Special Issue is devoted to understanding age-related changes in proteostasis and the effects on cellular and physiological functions. 

Dr. Esther Siew Peng Wong
Dr. Boon Seng Wong
Guest Editors

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Keywords

  • aging
  • proteostasis
  • mitochondrial function
  • metabolism
  • age-related diseases
  • protein aggregation
  • protein degradation

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Published Papers (1 paper)

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Research

21 pages, 1721 KiB  
Article
Decoupling of mRNA and Protein Expression in Aging Brains Reveals the Age-Dependent Adaptation of Specific Gene Subsets
by Inès Khatir, Marie A. Brunet, Anna Meller, Florent Amiot, Tushar Patel, Xavier Lapointe, Jessica Avila Lopez, Noé Guilloy, Anne Castonguay, Mohammed Amir Husain, Joannie St. Germain, François-Michel Boisvert, Mélanie Plourde, Xavier Roucou and Benoit Laurent
Cells 2023, 12(4), 615; https://doi.org/10.3390/cells12040615 - 14 Feb 2023
Cited by 3 | Viewed by 3300
Abstract
During aging, changes in gene expression are associated with a decline in physical and cognitive abilities. Here, we investigate the connection between changes in mRNA and protein expression in the brain by comparing the transcriptome and proteome of the mouse cortex during aging. [...] Read more.
During aging, changes in gene expression are associated with a decline in physical and cognitive abilities. Here, we investigate the connection between changes in mRNA and protein expression in the brain by comparing the transcriptome and proteome of the mouse cortex during aging. Our transcriptomic analysis revealed that aging mainly triggers gene activation in the cortex. We showed that an increase in mRNA expression correlates with protein expression, specifically in the anterior cingulate cortex, where we also observed an increase in cortical thickness during aging. Genes exhibiting an aging-dependent increase of mRNA and protein levels are involved in sensory perception and immune functions. Our proteomic analysis also identified changes in protein abundance in the aging cortex and highlighted a subset of proteins that were differentially enriched but exhibited stable mRNA levels during aging, implying the contribution of aging-related post- transcriptional and post-translational mechanisms. These specific genes were associated with general biological processes such as translation, ribosome assembly and protein degradation, and also important brain functions related to neuroplasticity. By decoupling mRNA and protein expression, we have thus characterized distinct subsets of genes that differentially adjust to cellular aging in the cerebral cortex. Full article
(This article belongs to the Special Issue Protein Biology of the Aging Process)
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