Autophagy in Cell Survival and Growth

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Autophagy".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 4149

Special Issue Editor


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Guest Editor
Paul Albrechtsen Research Institute, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada
Interests: autophagy; cell death; cancer; signaling pathway; microbiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Autophagy is a "self-digestion" process conserved in eukaryotic cells. During autophagy, intracellular materials (cargo), such as dysfunctional organelles, protein aggregates, lipid droplets, and microbial pathogens, are delivered to the lysosome to be degraded. Based on the transportation method, autophagy can be classified into three main types: macroautophagy, which is the most extensively studied; chaperone-mediated autophagy; and microautophagy.

Autophagy plays a critical role in cellular homeostasis and is associated with the progression of various diseases, such as cancer and neurodegenerative disorders. It primarily supports cell survival, whereby autophagic degradation generates small molecules for biosynthesis and energy production. Recent studies have shown that autophagy promotes cell growth, which refers to an increase in cell numbers, and is regulated by cell proliferation and cell survival.

This Special Issue aims to collect original research and review articles on the underlying mechanisms of the autophagy regulation of cell survival and growth in various eukaryotic cells. 

Dr. Yongqiang Chen
Guest Editor

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Keywords

  • autophagy
  • cell survival
  • cell death
  • cell growth
  • proliferation

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Published Papers (1 paper)

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Review

37 pages, 3303 KiB  
Review
Crosstalk between Autophagy and RLR Signaling
by Po-Yuan Ke
Cells 2023, 12(6), 956; https://doi.org/10.3390/cells12060956 - 21 Mar 2023
Cited by 5 | Viewed by 3223
Abstract
Autophagy plays a homeostatic role in regulating cellular metabolism by degrading unwanted intracellular materials and acts as a host defense mechanism by eliminating infecting pathogens, such as viruses. Upon viral infection, host cells often activate retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling [...] Read more.
Autophagy plays a homeostatic role in regulating cellular metabolism by degrading unwanted intracellular materials and acts as a host defense mechanism by eliminating infecting pathogens, such as viruses. Upon viral infection, host cells often activate retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling to induce the transcription of type I interferons, thus establishing the first line of the innate antiviral response. In recent years, numerous studies have shown that virus-mediated autophagy activation may benefit viral replication through different actions on host cellular processes, including the modulation of RLR-mediated innate immunity. Here, an overview of the functional molecules and regulatory mechanism of the RLR antiviral immune response as well as autophagy is presented. Moreover, a summary of the current knowledge on the biological role of autophagy in regulating RLR antiviral signaling is provided. The molecular mechanisms underlying the crosstalk between autophagy and RLR innate immunity are also discussed. Full article
(This article belongs to the Special Issue Autophagy in Cell Survival and Growth)
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