Molecular Signalings in Hair Regeneration
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 1520
Special Issue Editor
Interests: hair regeneration; hair follicular stem cells; wound healing; scarless healing; wound-induced hair neogenesis; skin aging; squamous cell carcinoma; obesity and diabetes; digit regeneration; Wnt signaling; drug development; lineage tracing; tissue clearing; skin pattern; human organ development; somatic mosaicism
Special Issue Information
Dear Colleagues,
Hair regeneration can occur through hair cycle activation, niche environment regulation, and wound-induced hair follicle neogenesis (WIHN) and may be utilized to treat alopecia. Previous studies on hair regeneration were limited to addressing intra-hair follicle regeneration through hair cycle activation, but the discovery of the phenomenon called WIHN by Ito et al., 2007, presented a new paradigm for hair regeneration and alopecia treatment. Hair regeneration is regulated by multiple signaling pathways, such as the Wnt/β-catenin, Sonic hedgehog (SHH), and PI3K/Akt signaling pathways. In particular, WIHN was found to be significantly induced by the activation of the Wnt/β-catein and SHH pathways. Ultimately, in-depth studies of the molecular signaling pathways involved in hair regeneration may provide new fundamental treatments for alopecia.
This Special Issue will provide a collection of original research and review articles on molecular signaling pathways in hair regeneration that may ultimately contribute to the treatment of alopecia. Potential topics include the role of molecular signaling pathways in hair regeneration; multiple signaling pathways regulating WIHN; the relationship between hair follicle development and regeneration; molecular signaling pathways as therapeutic targets for alopecia; development of new treatments by controlling signaling involved in hair regeneration.
Dr. Soung-Hoon Lee
Guest Editor
Manuscript Submission Information
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Keywords
- hair regeneration
- wound-induced hair follicle neogenesis (WIHN)
- Wnt/β-catein signaling pathway
- sonic hedgehog (SHH) signaling pathway
- alopecia treatment
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