Drosophila: Contribution to Cell Research

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 20 June 2025 | Viewed by 1760

Special Issue Editor


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Guest Editor
Department of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, The George Washington (GW) Cancer Center, Washington, DC 20052, USA
Interests: cell signaling; development; cell culture; drosophila
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Special Issue Information

Dear Colleagues,

We are delighted to announce an upcoming Special Issue titled “Drosophila: Contribution to Cell Research”. This issue aims to explore the significance of Drosophila, the humble fruit fly, in advancing our understanding of cell biology, gene function, and disease processes.

Drosophila melanogaster has been an invaluable organism in cell and molecular biology research for more than a century. Its genetic tractability, combined with a deep understanding of its development and physiology, has made it an essential model organism for the study of cell biology, genetics, and disease. As such, it has contributed tremendously to our knowledge in these areas, and continues to serve as a robust experimental platform.

This Special Issue invites both review and original research articles that explore Drosophila's contribution to cell research. The topics of interest include, but are not limited to:

  • Drosophila in cell and developmental biology research;
  • Insights into human diseases from Drosophila models;
  • Techniques and methodologies involving Drosophila;
  • Genetic manipulations and their implications in Drosophila;
  • Cellular processes as studied in Drosophila;
  • Translational research involving Drosophila.

The discoveries and insights from Drosophila research have profoundly impacted the broader field of biology and continue to do so. This Special Issue aims to highlight the diverse and significant ways in which Drosophila contributes to cell research. We hope that through a collection of insightful papers, this issue will underscore the value of this versatile model organism in advancing biological sciences.

We look forward to your contributions.

Dr. Xiaoyan Zheng
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Drosophila
  • cell research
  • cell biology
  • gene function
  • disease processes
  • fruit fly

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Published Papers (1 paper)

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Review

20 pages, 1119 KiB  
Review
The Neural Correlations of Olfactory Associative Reward Memories in Drosophila
by Yu-Chun Lin, Tony Wu and Chia-Lin Wu
Cells 2024, 13(20), 1716; https://doi.org/10.3390/cells13201716 - 17 Oct 2024
Viewed by 1296
Abstract
Advancing treatment to resolve human cognitive disorders requires a comprehensive understanding of the molecular signaling pathways underlying learning and memory. While most organ systems evolved to maintain homeostasis, the brain developed the capacity to perceive and adapt to environmental stimuli through the continuous [...] Read more.
Advancing treatment to resolve human cognitive disorders requires a comprehensive understanding of the molecular signaling pathways underlying learning and memory. While most organ systems evolved to maintain homeostasis, the brain developed the capacity to perceive and adapt to environmental stimuli through the continuous modification of interactions within a gene network functioning within a broader neural network. This distinctive characteristic enables significant neural plasticity, but complicates experimental investigations. A thorough examination of the mechanisms underlying behavioral plasticity must integrate multiple levels of biological organization, encompassing genetic pathways within individual neurons, interactions among neural networks providing feedback on gene expression, and observable phenotypic behaviors. Model organisms, such as Drosophila melanogaster, which possess more simple and manipulable nervous systems and genomes than mammals, facilitate such investigations. The evolutionary conservation of behavioral phenotypes and the associated genetics and neural systems indicates that insights gained from flies are pertinent to understanding human cognition. Rather than providing a comprehensive review of the entire field of Drosophila memory research, we focus on olfactory associative reward memories and their related neural circuitry in fly brains, with the objective of elucidating the underlying neural mechanisms, thereby advancing our understanding of brain mechanisms linked to cognitive systems. Full article
(This article belongs to the Special Issue Drosophila: Contribution to Cell Research)
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