Insight into Lipid Droplets

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Biophysics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1327

Special Issue Editor

1. Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA
2. Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
Interests: lipid droplet biology; lipid metabolism; cancer cachexia; cancer metabolism

Special Issue Information

Dear Colleagues,

Lipid droplets (LDs) are unique intracellular organelles that contain a neutral lipid core encased with a monolayer of phospholipid and binding proteins. LDs were long-thought to be inert energy storage reservoirs, yet have been discovered be active, dynamic and closely contacted with other organelles, which enable LDs play critical roles in lipid metabolism. LDs have been found to be closely associated with various diseases such as obesity, non-alcoholic fatty liver diseases, cardiovascular diseases, neurodegenerative diseases, cancer, etc. As the knowledge of LD biology is accumulating, a better understanding of the biogenesis, growth and utilization of LDs makes it more feasible to target LDs to treat certain diseases.

This Special Issue will examine the biogenesis and growth of LDs; interactions between LDs and other organelles; identification and functions of novel LD proteins; methods to isolate and examine LDs; role of LDs in metabolic diseases; targeting LDs for pharmacological therapies; application of LDs in drug delivery.

Dr. Jinhai Yu
Guest Editor

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Keywords

  • lipid droplet
  • lipid droplet protein
  • lipid droplet biogenesis
  • lipid droplet growth
  • lipid droplet degradation
  • lipid droplet–organelle interaction
  • lipid metabolism
  • lipid-metabolism-related diseases

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Published Papers (1 paper)

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Review

15 pages, 749 KiB  
Review
Microlipophagy from Simple to Complex Eukaryotes
by Ravinder Kumar, Colin Arrowood, Micah B. Schott and Taras Y. Nazarko
Cells 2025, 14(2), 141; https://doi.org/10.3390/cells14020141 - 18 Jan 2025
Viewed by 1009
Abstract
Lipophagy is a selective degradation of lipid droplets in lysosomes or vacuoles. Apart from its role in generating energy and free fatty acids for membrane repair, growth, and the formation of new membranes, lipophagy emerges as a key player in other cellular processes [...] Read more.
Lipophagy is a selective degradation of lipid droplets in lysosomes or vacuoles. Apart from its role in generating energy and free fatty acids for membrane repair, growth, and the formation of new membranes, lipophagy emerges as a key player in other cellular processes and disease pathogenesis. While fungal, plant, and algal cells use microlipophagy, the most prominent form of lipophagy in animal cells is macrolipophagy. However, recent studies showed that animal cells can also use microlipophagy to metabolize their lipid droplets. Therefore, to no surprise, microlipophagy is conserved from simple unicellular to the most complex multicellular eukaryotes, and many eukaryotic cells can operate both forms of lipophagy. Macrolipophagy is the most studied and better understood at the molecular level, while our understanding of microlipophagy is very sparse. This review will discuss microlipophagy from the perspective of its conservation in eukaryotes and its importance in diseases. To better appreciate the conserved nature of microlipophagy, different organisms and types of cells in which microlipophagy has been reported are also shown in a tabular form. We also point toward the gaps in our understanding of microlipophagy, including the signaling behind microlipophagy, especially in the cells of complex multicellular organisms. Full article
(This article belongs to the Special Issue Insight into Lipid Droplets)
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