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Chemosensors
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Aptasensors: Applications in Life Science and Environmental Technology
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Aptasensors: Applications in Life Science and Environmental Technology

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Applied Chemical Sensors".

Deadline for manuscript submissions: closed (15 January 2022) | Viewed by 16050

Special Issue Editor

Dr. Dieter Frense

E-Mail Website
Guest Editor
Institute for Bioprocessing and Analytical Measurement Techniques, Heilbad Heiligenstadt, Germany
Interests: biosensors; aptamers; impedance spectroscopy; voltammetry; mass spectrometry; multisensor platforms

Special Issue Information

Aptamers are typically single-stranded DNA/RNA sequences with a length of 15 to 40 bases, which were previously selected from a combinatorial library of synthetic nucleic acids using SELEX technology (systematic evolution of ligands by exponential enrichment). The chemical versatility of the synthesized aptamers enables the incorporation of modified bases or amino acids, as well as other functional groups in the secondary structures. So far, various types of aptasensors have been developed. Almost all transducer principles have been used, such as optical and electrochemical approaches as well as electrochemical, potentiometric and micro-gravimetric transducers.

This Special Edition is intended to provide an overview of current topics and the latest lines of development in the rapidly growing research area of aptasensors. The focus is on applications in the field of healthcare and environmental and food analysis, as well as studies on increasing stability and sensitivity.

We would like to invite you to participate by submitting results of your research using aptamer-based biosensors. In addition to a wide variety of applications, the focus is also on new (multisensor) platforms and fast analyses. We welcome both original articles and review articles that cover the state-of-the-art in this rapidly developing area.

Dr. Dieter Frense
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Aptasensors
  • Biosensors
  • Chemosensors
  • Electrochemical sensors
  • Optical sensors
  • Mass sensitive sensors
  • Clinical diagnostics
  • Environmental analysis
  • Food analysis

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Published Papers (4 papers)

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Research

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14 pages, 3058 KiB  
Communication
Aptamer-Sensitized Nanoribbon Biosensor for Ovarian Cancer Marker Detection in Plasma
by Yuri D. Ivanov, Kristina A. Malsagova, Tatyana O. Pleshakova, Rafael A. Galiullin, Andrey F. Kozlov, Ivan D. Shumov, Vladimir P. Popov, Svetlana I. Kapustina, Irina A. Ivanova, Arina I. Isaeva, Fedor V. Tikhonenko, Nikolay E. Kushlinskii, Alexander A. Alferov, Vadim Yu. Tatur, Vadim S. Ziborov, Oleg F. Petrov, Alexander V. Glukhov and Alexander I. Archakov
Chemosensors 2021, 9(8), 222; https://doi.org/10.3390/chemosensors9080222 - 13 Aug 2021
Cited by 5 | Viewed by 2750
Abstract
The detection of CA 125 protein in buffer solution with a silicon-on-insulator (SOI)-based nanoribbon (NR) biosensor was experimentally demonstrated. In the biosensor, sensor chips, bearing an array of 12 nanoribbons (NRs) with n-type conductance, were employed. In the course of the analysis with [...] Read more.
The detection of CA 125 protein in buffer solution with a silicon-on-insulator (SOI)-based nanoribbon (NR) biosensor was experimentally demonstrated. In the biosensor, sensor chips, bearing an array of 12 nanoribbons (NRs) with n-type conductance, were employed. In the course of the analysis with the NR biosensor, the target protein was biospecifically captured onto the surface of the NRs, which was sensitized with covalently immobilized aptamers against CA 125. Atomic force microscopy (AFM) and mass spectrometry (MS) were employed in order to confirm the formation of the probe–target complexes on the NR surface. Via AFM and MS, the formation of aptamer–antigen complexes on the surface of SOI substrates with covalently immobilized aptamers against CA 125 was revealed, thus confirming the efficient immobilization of the aptamers onto the SOI surface. The biosensor signal, resulting from the biospecific interaction between CA 125 and the NR-immobilized aptamer probes, was shown to increase with an increase in the target protein concentration. The minimum detectable CA 125 concentration was as low as 1.5 × 10−17 M. Moreover, with the biosensor proposed herein, the detection of CA 125 in the plasma of ovarian cancer patients was demonstrated. Full article
(This article belongs to the Special Issue Aptasensors: Applications in Life Science and Environmental Technology)
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11 pages, 2666 KiB  
Article
Sensitive Electrochemical Detection of Tryptophan Using a Hemin/G-Quadruplex Aptasensor
by Ayemeh Bagheri Hashkavayi, Jahan Bakhsh Raoof and Ki Soo Park
Chemosensors 2020, 8(4), 100; https://doi.org/10.3390/chemosensors8040100 - 15 Oct 2020
Cited by 17 | Viewed by 3872
Abstract
In this study, we design an electrochemical aptasensor with an enzyme-free amplification method to detect tryptophan (Trp). For the amplified electrochemical signal, the screen-printed electrode was modified with dendritic gold nanostructures (DGNs)/magnetic double-charged diazoniabicyclo [2.2.2] octane dichloride silica hybrid (Fe3O4 [...] Read more.
In this study, we design an electrochemical aptasensor with an enzyme-free amplification method to detect tryptophan (Trp). For the amplified electrochemical signal, the screen-printed electrode was modified with dendritic gold nanostructures (DGNs)/magnetic double-charged diazoniabicyclo [2.2.2] octane dichloride silica hybrid (Fe3O4@SiO2/DABCO) to increase the surface area as well as electrical conductivity, and the hemin/G-quadruplex aptamer was immobilized. The presence of Trp improved the catalytic characteristic of hemin/G-quadruplex structure, which resulted in the efficient catalysis of the H2O2 reduction. As the concentration of Trp increased, the intensity of H2O2 reduction signal increased, and Trp was measured in the range of 0.007–200 nM with a detection limit of 0.002 nM. Compared with previous models, our sensor displayed higher detection sensitivity and specificity for Trp. Furthermore, we demonstrated that the proposed aptasensor successfully determined Trp in human serum samples, thereby proving its practical applicability. Full article
(This article belongs to the Special Issue Aptasensors: Applications in Life Science and Environmental Technology)
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Review

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37 pages, 9766 KiB  
Review
Contribution of Nanomaterials to the Development of Electrochemical Aptasensors for the Detection of Antimicrobial Residues in Food Products
by Valérie Gaudin
Chemosensors 2021, 9(4), 69; https://doi.org/10.3390/chemosensors9040069 - 30 Mar 2021
Cited by 8 | Viewed by 3826
Abstract
The detection of antimicrobial residues in food products of animal origin is of utmost importance. Indeed antimicrobial residues could be present in animal derived food products because of animal treatments for curative purposes or from illegal use. The usual screening methods to detect [...] Read more.
The detection of antimicrobial residues in food products of animal origin is of utmost importance. Indeed antimicrobial residues could be present in animal derived food products because of animal treatments for curative purposes or from illegal use. The usual screening methods to detect antimicrobial residues in food are microbiological, immunological or physico-chemical methods. The development of biosensors to propose sensitive, cheap and quick alternatives to classical methods is constantly increasing. Aptasensors are one of the major trends proposed in the literature, in parallel with the development of immunosensors based on antibodies. The characteristics of electrochemical sensors (i.e., low cost, miniaturization, and portable instrumentation) make them very good candidates to develop screening methods for antimicrobial residues in food products. This review will focus on the recent advances in the development of electrochemical aptasensors for the detection of antimicrobial residues in food products. The contribution of nanomaterials to improve the performance characteristics of electrochemical aptasensors (e.g., Sensitivity, easiness, stability) in the last ten years, as well as signal amplification techniques will be highlighted. Full article
(This article belongs to the Special Issue Aptasensors: Applications in Life Science and Environmental Technology)
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15 pages, 1314 KiB  
Review
Fluorogenic Aptasensors with Small Molecules
by Eun-Song Lee, Jeong Min Lee, Hea-Jin Kim and Young-Pil Kim
Chemosensors 2021, 9(3), 54; https://doi.org/10.3390/chemosensors9030054 - 10 Mar 2021
Cited by 12 | Viewed by 4730
Abstract
Aptamers are single-stranded DNA or RNA molecules that can be identified through an iterative in vitro selection–amplification process. Among them, fluorogenic aptamers in response to small molecules have been of great interest in biosensing and bioimaging due to their rapid fluorescence turn-on signals [...] Read more.
Aptamers are single-stranded DNA or RNA molecules that can be identified through an iterative in vitro selection–amplification process. Among them, fluorogenic aptamers in response to small molecules have been of great interest in biosensing and bioimaging due to their rapid fluorescence turn-on signals with high target specificity and low background noise. In this review, we report recent advances in fluorogenic aptasensors and their applications to in vitro diagnosis and cellular imaging. These aptasensors modulated by small molecules have been implemented in different modalities that include duplex or molecular beacon-type aptasensors, aptazymes, and fluorogen-activating aptamer reporters. We highlight the working principles, target molecules, modifications, and performance characteristics of fluorogenic aptasensors, and discuss their potential roles in the field of biosensor and bioimaging with future directions and challenges. Full article
(This article belongs to the Special Issue Aptasensors: Applications in Life Science and Environmental Technology)
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