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Chemosensors
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Nanoprobes for Biosensing and Bioimaging
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Nanoprobes for Biosensing and Bioimaging

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Nanostructures for Chemical Sensing".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 9129

Special Issue Editor

Prof. Dr. Qiangbin Wang

E-Mail Website
Guest Editor
Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China
Interests: NIR-II fluorescence imaging

Special Issue Information

Dear Colleagues,

Nanomaterial-based sensors and probes exhibit salient merits over conventional molecular probes, including strong resistance to interference, facilitating manipulation of the pharmacokinetic profiles of probes, enhanced sensitivity and selectivity, as well as simultaneously realizing multiple detection, which could meet the complicated diagnosis and analysis requirement in living organisms. With new nanoprobes development and methodological advances, they greatly promote the booming development in this field, meanwhile, further open possibilities for insights into the mysteries of living bodies and mechanisms of diseases.

The aim of this Special Issue is to provide a forum for mutual communication among scientists in the field of chemistry, materials science, biomedicine, and physics. We welcome papers focused on developing novel nanoprobe systems, establishing novel biochemical analysis strategies, as well as demonstrating all main concerns to achieve their real clinical translational applications.

Prof. Dr. Qiangbin Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensing
  • bioimaging
  • nanoprobe
  • molecular imaging
  • disease detection

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Published Papers (5 papers)

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Research

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13 pages, 3590 KiB  
Article
A Metal Organic Framework-Based Light Scattering ELISA for the Detection of Staphylococcal Enterotoxin B
by Kai Mao, Lili Tian, Yujie Luo, Qian Li, Xi Chen, Lei Zhan, Yuanfang Li, Chengzhi Huang and Shujun Zhen
Chemosensors 2023, 11(8), 453; https://doi.org/10.3390/chemosensors11080453 - 13 Aug 2023
Cited by 2 | Viewed by 1654
Abstract
Enzyme-linked immunosorbent assay (ELISA) is one of the most commonly used method for the detection of staphylococcal enterotoxin B (SEB), the main protein toxin causing staphylococcal food poisoning. However, the traditional ELISA reaction needs to be stopped by sulfuric acid to obtain stable [...] Read more.
Enzyme-linked immunosorbent assay (ELISA) is one of the most commonly used method for the detection of staphylococcal enterotoxin B (SEB), the main protein toxin causing staphylococcal food poisoning. However, the traditional ELISA reaction needs to be stopped by sulfuric acid to obtain stable colorimetric signal, and it is easily influenced by a colored sample. In order to address this problem, a new ELISA method using zeolite imidazolate skeleton-8 metal-organic framework (ZIF-8 MOF) as a light scattering (LS) reporter for SEB detection was developed in this work. ZIF-8 MOF has the characteristics of high porosity, large specific surface area, clear pore structure, and adjustable size, which is one of the most representative MOFs constructed from Zn2+ and 2-methylimidazole (2-mIM). The 2-mIM ligand of ZIF-8 exhibited antioxidant activity and can strongly react with H2O2, which could destroy the structure of ZIF-8, resulting in the obvious decrease in LS intensity. We combined this specific reaction with the sandwich immune reaction to construct the LS ELISA method for the successful detection of SEB. This method is more reliable than commercial tests kits for the detection of colored samples, and it is simple, sensitive, and selective, and has great potential in the detection of other toxins by simply changing the corresponding recognition units. Full article
(This article belongs to the Special Issue Nanoprobes for Biosensing and Bioimaging)
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14 pages, 4239 KiB  
Article
Development of a New Hydrogen Sulfide Fluorescent Probe Based on Coumarin–Chalcone Fluorescence Platform and Its Imaging Application
by Hanwen Chi, Lei Gu, Qian Zhang, Yonghe Tang, Rui Guo and Weiying Lin
Chemosensors 2023, 11(8), 428; https://doi.org/10.3390/chemosensors11080428 - 2 Aug 2023
Cited by 3 | Viewed by 1692
Abstract
Hydrogen sulfide (H2S), as one of the critical gaseous signaling molecules, has important physiological functions in the human body, and abnormal levels of hydrogen sulfide are closely related to tumors, Parkinson’s disease, Alzheimer’s disease, and other diseases. In order to enable [...] Read more.
Hydrogen sulfide (H2S), as one of the critical gaseous signaling molecules, has important physiological functions in the human body, and abnormal levels of hydrogen sulfide are closely related to tumors, Parkinson’s disease, Alzheimer’s disease, and other diseases. In order to enable the detection of H2S in the physiological environment, herein, a new H2S fluorescence probe, named C-HS, based on a coumarin–chalcone fluorescence platform was developed. The fluorescence probe provides specific recognition of H2S within a wide pH detection range (5.5–8.5), a rapid recognition response (within 10 min) for H2S molecules, and a high selectivity for competing species. The probe C-HS possesses low cytotoxicity and is used to achieve the detection of exogenous/ endogenous H2S in living cells, indicating that the constructed probe C-HS has the ability to track changes in intracellular H2S levels. Therefore, probe C-HS could be a potential tool for the early diagnosis of H2S-related diseases. Full article
(This article belongs to the Special Issue Nanoprobes for Biosensing and Bioimaging)
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9 pages, 3129 KiB  
Communication
A GSH-Activatable Theranostic Prodrug Based on Photoinduced Electron Transfer for Cancer Fluorescence Imaging and Therapy
by Xuan Zhao, Xiaolong Zeng, Xinyu Wu, Lihong Shi, Sumin Zhu and Wen Sun
Chemosensors 2023, 11(7), 397; https://doi.org/10.3390/chemosensors11070397 - 15 Jul 2023
Cited by 1 | Viewed by 1933
Abstract
Traditional chemotherapeutic drugs have limitations due to their non-targeted ability toward cancer cells. Stimuli-activatable prodrugs are designed to overcome these obstacles. However, the real-time monitoring of stimuli-activatable theranostic prodrugs still poses challenges. Herein, a prodrug (Fe–SS–HCy), consisting of a ferrocene-modified hemicyanine linked via [...] Read more.
Traditional chemotherapeutic drugs have limitations due to their non-targeted ability toward cancer cells. Stimuli-activatable prodrugs are designed to overcome these obstacles. However, the real-time monitoring of stimuli-activatable theranostic prodrugs still poses challenges. Herein, a prodrug (Fe–SS–HCy), consisting of a ferrocene-modified hemicyanine linked via a disulfide bond, is synthesized for anticancer imaging and therapy. Before activation, the toxicity of Fe–SS–HCy is low. The fluorescence of Fe–SS–HCy is quenched by ferrocene due to photoinduced electron transfer. After being taken up by cancer cells, the intracellular GSH activates Fe–SS–HCy, which releases HCy. The fluorescence of HCy is restored and selectively accumulates in the mitochondria, which further produce reactive oxygen species (ROS) to induce cancer cell death. Thus, this “off-on” fluorogenic HCy presents a new strategy for monitoring prodrug activation in real-time and for enhancing therapeutic efficacy with reduced side effects. Full article
(This article belongs to the Special Issue Nanoprobes for Biosensing and Bioimaging)
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13 pages, 6940 KiB  
Article
SPR-Enhanced Au@Fe3O4 Nanozyme for the Detection of Hydroquinone
by Bin Zhang, Xiaoming Wang, Wei Hu, Yiquan Liao, Yichang He, Bohua Dong, Minggang Zhao and Ye Ma
Chemosensors 2023, 11(7), 392; https://doi.org/10.3390/chemosensors11070392 - 14 Jul 2023
Cited by 2 | Viewed by 1675
Abstract
Artificial nanozymes that are based on ferric oxides have drawn enormous attention due to their high stability, high efficiency, and low cost as compared with natural enzymes. Due to the unique optical plasmonic properties, gold nanoparticles (Au NPs) have been widely utilized in [...] Read more.
Artificial nanozymes that are based on ferric oxides have drawn enormous attention due to their high stability, high efficiency, and low cost as compared with natural enzymes. Due to the unique optical plasmonic properties, gold nanoparticles (Au NPs) have been widely utilized in the fields of colorimetric, Raman, and fluorescence sensing. In this work, a photo-responsive Au@Fe3O4 nanozyme is prepared with outstanding peroxidase-like activity. The hot electrons of Au NPs that are excited by a surface plasmon resonance (SPR) effect of NPs improve the catalytic activity of Au@Fe3O4 in oxidizing 3,3′,5,5′-tetramethylbenzidine (TMB) and the detection of hydroquinone (HQ). The magnetic separation and reusability of the nanozyme further lower its costs. The detection linear range of the sensor is 0–30 μM and the lowest detection limit is 0.29 μM. Especially in the detection of real water samples, a good recovery rate is obtained, which provides promising references for the development of the HQ detection technology in seawater. Full article
(This article belongs to the Special Issue Nanoprobes for Biosensing and Bioimaging)
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Review

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23 pages, 10977 KiB  
Review
Advanced NIR-II Fluorescence Imaging Technology for Precise Evaluation of Nanomedicine Delivery in Cancer Therapy
by Meng Li, Tuanwei Li, Feng Wu, Feng Ren, Sumei Xue and Chunyan Li
Chemosensors 2024, 12(6), 113; https://doi.org/10.3390/chemosensors12060113 - 16 Jun 2024
Viewed by 1448
Abstract
Tumors represent a significant threat to human health, underscoring the critical need for effective treatment strategies. However, conventional drug therapies are hampered by imprecise delivery, potentially leading to inadequate efficacy and severe side effects. The strategic development of nanomedicines is believed to harbor [...] Read more.
Tumors represent a significant threat to human health, underscoring the critical need for effective treatment strategies. However, conventional drug therapies are hampered by imprecise delivery, potentially leading to inadequate efficacy and severe side effects. The strategic development of nanomedicines is believed to harbor enormous potential for enhancing drug safety and efficacy, especially for precise, tumor-targeted therapies. Nevertheless, the fate of these nanomedicines within the human body is intricately governed by various physiological barriers and complex environments, posing challenges to predicting their behaviors. Near-infrared II (NIR-II, 1000–1700 nm) fluorescence imaging technology serves as a non-invasive, real-time monitoring method that can be applied for the precise evaluation of nanomedicine delivery in cancer therapy due to its numerous advantages, including high tissue penetration depth, high spatiotemporal resolution, and high signal-to-noise ratio. In this review, we comprehensively summarize the pivotal role of NIR-II fluorescence imaging in guiding the intratumoral precise delivery of nanomedicines and shed light on its current applications, challenges, and promising prospects in this field. Full article
(This article belongs to the Special Issue Nanoprobes for Biosensing and Bioimaging)
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