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Latest Advances in Molecular and Cellular Virology

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2864

Special Issue Editors


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Guest Editor
Department of Medicine, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Interests: viral evolution; molecular mechanisms of immune evasion; epitope immunodominance hierarchies; influenza; Sars-Cov-2; computational biology

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Guest Editor
1. Former Department of Rheumatology and Immunology, Harvard University, Cambridge, MA, USA
2. BioMimetix, Greenwood Village, CO 8011, USA
Interests: immune response to infection; parasitism; inflammation

Special Issue Information

Dear Colleagues,

From phages that infected our monokaryotic forbears to the first transmission of the influenza virus among humans possibly more than 8000 years ago, through to the COVID-19 pandemic of recent years, and into unknown zoonoses and emergences that will continue to pose new threats to public health in the foreseeable future, we can see a clear and essential need to understand the molecular mechanisms of viral infection.

Rapid, recent developments in a new generation of investigatory tools enhance our ability to study viruses at multiple levels with a combination of genetic, structural, bioinformatics, and computational methods to augment in vitro, in vivo, and population-based studies.

We are pleased to announce a special edition of Current Issues in Molecular Biology devoted to reporting the lastest advances in molecular virology research. In this issue, we intend to focus primarily on studies of viral mechanisms that contribute to infectivity or transmissibility, virulence, and immune evasion. Importantly, we seek to understand the ongoing evolution of such mechanisms, which illuminate the battle lines of our continued coexistence with these pathogens, and which highlight promising new treatment strategies and frontiers in virus biology.

Dr. David MacLeod
Dr. David S. Silberstein
Guest Editors

Manuscript Submission Information

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Keywords

  • viral evolution
  • molecular virology
  • immune evasion
  • infectivity
  • virulence factor
  • antigen
  • capsid
  • transmissibilty

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Published Papers (1 paper)

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Research

13 pages, 2932 KiB  
Article
Diagnosis of a Rabbit Hemorrhagic Disease Virus 2 (RHDV2) and the Humoral Immune Protection Effect of VP60 Vaccine
by Zhaoming Li, Kaimin Song, Yongzhen Du, Zhuanglong Zhang, Rupeng Fan, Pimiao Zheng and Jianzhu Liu
Curr. Issues Mol. Biol. 2023, 45(8), 6605-6617; https://doi.org/10.3390/cimb45080417 - 8 Aug 2023
Cited by 1 | Viewed by 2432
Abstract
Rabbit hemorrhagic disease (RHD) is known as rabbit plague and hemorrhagic pneumonia. It is an acute, septic, and highly fatal infectious disease caused by the Lagovirus rabbit hemorrhagic disease virus (RHDV) in the family Caliciviridae that infects wild and domestic rabbits and hares [...] Read more.
Rabbit hemorrhagic disease (RHD) is known as rabbit plague and hemorrhagic pneumonia. It is an acute, septic, and highly fatal infectious disease caused by the Lagovirus rabbit hemorrhagic disease virus (RHDV) in the family Caliciviridae that infects wild and domestic rabbits and hares (lagomorphs). At present, RHDV2 has caused huge economic losses to the commercial rabbit trade and led to a decline in the number of wild lagomorphs worldwide. We performed a necropsy and pathological observations on five dead rabbits on a rabbit farm in Tai’an, China. The results were highly similar to the clinical and pathological changes of typical RHD. RHDV2 strain was isolated and identified by RT-PCR, and partial gene sequencing and genetic evolution analysis were carried out. There were significant differences in genetic characteristics and antigenicity between RHDV2 and classical RHDV strain, and the vaccine prepared with the RHDV strain cannot effectively prevent rabbit infection with RHDV2. Therefore, we evaluated the protective efficacy of a novel rabbit hemorrhagic virus baculovirus vector inactivated vaccine (VP60) in clinical application by animal regression experiment. The result showed that VP60 could effectively induce humoral immunity in rabbits. The vaccine itself had no significant effect on the health status of rabbits. This study suggested that the clinical application of VP60 may provide new ideas for preventing the spread of RHD2. Full article
(This article belongs to the Special Issue Latest Advances in Molecular and Cellular Virology)
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