Aging and Oxidative Stress in Nervous System
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 3582
Special Issue Editor
Interests: aging and oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Currently, aging is considered to be a phenomenon with multifactorial causes. Therefore, a vast proliferation of theories and classifications have been proposed to explain the aging process. The most accepted hypothesis of aging is that of oxidative stress, which states that reactive oxygen species (ROS), produced via cellular aerobic metabolism, causes progressive oxidative damage throughout the cell, inducing its degeneration and death. In aerobic cells, mitochondria are the main source of ROS, which act mainly on the closest macromolecules such as the lipids of the mitochondrial membrane, the proteins of their enzymatic systems and, especially, the mitochondrial DNA. The lipids of cell membranes are biomolecules that are highly susceptible to being attacked by free radicals.
The nervous system is highly susceptible to oxidative stress and aging due to its rich chemical composition of polyunsaturated fatty acids, its high metabolic rate and a deficient antioxidant system. This involves a progressive loss of motor, sensory and cognitive functions, which is considered to happen because of the degenerative changes that occur with age. On the other hand, many pathologies of the nervous system occur more frequently as age progresses. The changes that are induced by aging and the associated oxidative stress in neurons and glial cells, as well as in the neurotransmission and in the central, peripheral and enteric nervous system, are of great interest, since they allow us to understand a universal phenomenon that affects all living things. Therefore, all levels of analysis are important, from the molecular and cellular levels to the tissue level, as are possible strategies, such as antioxidant molecules, to counteract it.
Dr. Laura Lõpez-Pingarrõn
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress
- aging
- central nervous system
- antioxidant
- enteric nervous system
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
