Clinical Progression and Treatment Outcome of Multiple Myeloma

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 865

Special Issue Editors


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Guest Editor
Division of Medical Oncology and Haematology, Princess Margaret Cancer Centre, 700 University Avenue, Toronto, ON M5G 1X6, Canada
Interests: multiple myeloma; clinical trials; immunotherapies; secondary immunodeficiency

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Guest Editor
Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
Interests: understanding and improving health outcomes of patients with plasma cell disorders; multiple myeloma; systemic light chain amyloidosis

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Guest Editor
Department of Hematology, Jewish General Hospital, Montreal, QC H3T 1E2, Canada
Interests: myeloma; autologous stem cell transplant

Special Issue Information

Dear Colleagues,

The treatment of multiple myeloma is undergoing rapid changes due to the approval of novel immunotherapies as well as novel treatment combinations. The complexity of treatment selection and sequencing has increased drastically, leaving many unanswered questions for clinicians. Clinical trials, while critically important for establishing efficacy and safety, must be complemented by real-world evidence and insights in order to gain a fuller understanding of optimal treatment selection for patients. In addition, laboratory research can provide insights into strategies to overcome or avoid treatment resistance.

We are pleased to invite you to submit your research works to this Special Issue, which aims to deepen insights into the current treatment landscape of multiple myeloma. In this Special Issue, original research articles and reviews with a focus on all treatment phases are welcome, including induction (transplant eligible/ineligible), consolidation, maintenance, early relapse, and late relapse. We are particularly interested in clinical or laboratory predictors of response, as well as mechanisms of resistance and strategies to overcome these.

We look forward to receiving your contributions.

Dr. Guido Lancman
Dr. Alissa Visram
Dr. Rayan Kaedbey
Guest Editors

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Keywords

  • multiple myeloma
  • real-world predictors of response
  • sequencing
  • treatment selection
  • resistance mechanisms

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Published Papers (1 paper)

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Research

9 pages, 997 KiB  
Article
Doxycycline Plus Bortezomib-Containing Regimens for the Treatment of Light-Chain Amyloidosis in the Frontline Setting: Experience from the Amyloidosis Program of Calgary
by Ellen Lewis, Nowell Fine, Sylvia McCulloch, Jason Tay, Peter Duggan, Paola Neri, Nizar Bahlis and Victor H. Jimenez-Zepeda
Curr. Oncol. 2024, 31(9), 5608-5616; https://doi.org/10.3390/curroncol31090415 - 18 Sep 2024
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Abstract
Background: Pre-clinical and retrospective data suggest that doxycycline added to treatment regimens has benefit in AL amyloidosis. However, a recent multicenter, open-label, randomized controlled trial in AL amyloidosis patients treated with CyBorD did not demonstrate a progression-free survival (PFS) or cardiac PFS benefit [...] Read more.
Background: Pre-clinical and retrospective data suggest that doxycycline added to treatment regimens has benefit in AL amyloidosis. However, a recent multicenter, open-label, randomized controlled trial in AL amyloidosis patients treated with CyBorD did not demonstrate a progression-free survival (PFS) or cardiac PFS benefit with added doxycycline. Objective: The main objective of this study was to explore the role of doxycycline combined with bortezomib-containing regimens (BCRs) for newly diagnosed AL amyloidosis patients with cardiac involvement and to compare them with a cohort of concurrent patients treated with BCR only. Material and Methods: AL amyloidosis patients, newly diagnosed between January 2012 and March 2022, who were treated with BCR at the Amyloidosis Program of Calgary (APC) were evaluated. Results: Sixty-four concurrent patients were identified. Thirty-nine patients received doxycycline in addition to BCR (BCR-D) for a median of 8 months. The overall response rate was similar among the groups. No significant differences in VGPR/CR, dFLC at 1 month, time to first response, time to best response, or organ responses were noted between the BCR alone and BCR-D groups. Summary and Conclusions: Our retrospective study demonstrated that doxycycline combined with BCR failed to prolong OS, PFS, or cardiac responses compared with BCR alone in patients with cardiac AL amyloidosis. Full article
(This article belongs to the Special Issue Clinical Progression and Treatment Outcome of Multiple Myeloma)
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