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Diagnostics
Special Issues
Imaging of Rheumatoid Arthritis
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Imaging of Rheumatoid Arthritis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1922

Special Issue Editor

Dr. José Narváez

E-Mail Website
Guest Editor
Departamento de Radiología, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain
Interests: rheumatoid arthritis; ultrasound; MR imaging; PET-CT; termography

Special Issue Information

Dear Colleagues,

In Rheumatoid Arthritis, US and MRI play an important role. However, PET imaging is also becoming more and more important, e.g., for the differentiation between RA and other types of arthritis.

The purpose of this issue is to review hot topics in the imaging of RA, such as:

  • The use of US and MRI in clinically suspect arthralgia (CSA)-a pre-RA stage in which a patient with arthralgia presents with features clinically suspicious of the development of RA.
  • New MRI sequences that avoid contrast administration (Dixon technique, diffusion).
  • Nuclear medicine, including PET with with 18F-FDG, 18F-NaF, or other specific radiopharmaceuticals.

In addition, the current status of the following topics will be reviewed:

  • Conventional radiography in RA.
  • Imaging of RA of wrist and hand.
  • Imaging of RA of the foot and ankle.
  • Imaging of RA of the cervical spine.
  • Imaging of RA of great joints (shoulder, elbow, hip and knee).
  • Imaging of thoracic manifestations of rheumatoid arthritis.

Dr. José Antonio Narváez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clinical suspect arthralgia
  • power Doppler US
  • difussion MR imaging
  • Dixon sequences MR imaging
  • PET imaging

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Published Papers (2 papers)

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Research

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13 pages, 3040 KiB  
Article
External Validation of the Machine Learning-Based Thermographic Indices for Rheumatoid Arthritis: A Prospective Longitudinal Study
by Isabel Morales-Ivorra, Delia Taverner, Oriol Codina, Sonia Castell, Peter Fischer, Derek Onken, Píndaro Martínez-Osuna, Chakib Battioui and Manuel Alejandro Marín-López
Diagnostics 2024, 14(13), 1394; https://doi.org/10.3390/diagnostics14131394 - 30 Jun 2024
Viewed by 996
Abstract
External validation is crucial in developing reliable machine learning models. This study aimed to validate three novel indices—Thermographic Joint Inflammation Score (ThermoJIS), Thermographic Disease Activity Index (ThermoDAI), and Thermographic Disease Activity Index-C-reactive protein (ThermoDAI-CRP)—based on hand thermography and machine learning to assess joint [...] Read more.
External validation is crucial in developing reliable machine learning models. This study aimed to validate three novel indices—Thermographic Joint Inflammation Score (ThermoJIS), Thermographic Disease Activity Index (ThermoDAI), and Thermographic Disease Activity Index-C-reactive protein (ThermoDAI-CRP)—based on hand thermography and machine learning to assess joint inflammation and disease activity in rheumatoid arthritis (RA) patients. A 12-week prospective observational study was conducted with 77 RA patients recruited from rheumatology departments of three hospitals. During routine care visits, indices were obtained at baseline and week 12 visits using a pre-trained machine learning model. The performance of these indices was assessed cross-sectionally and longitudinally using correlation coefficients, the area under the receiver operating curve (AUROC), sensitivity, specificity, and positive and negative predictive values. ThermoDAI and ThermoDAI-CRP correlated with CDAI, SDAI, and DAS28-CRP cross-sectionally (ρ = 0.81; ρ = 0.83; ρ = 0.78) and longitudinally (ρ = 0.55; ρ = 0.61; ρ = 0.60), all p < 0.001. ThermoDAI and ThermoDAI-CRP also outperformed Patient Global Assessment (PGA) and PGA + C-reactive protein (CRP) in detecting changes in 28-swollen joint counts (SJC28). ThermoJIS had an AUROC of 0.67 (95% CI, 0.58 to 0.76) for detecting patients with swollen joints and effectively identified patients transitioning from SJC28 > 1 at baseline visit to SJC28 ≤ 1 at week 12 visit. These results support the effectiveness of ThermoJIS in assessing joint inflammation, as well as ThermoDAI and ThermoDAI-CRP in evaluating disease activity in RA patients. Full article
(This article belongs to the Special Issue Imaging of Rheumatoid Arthritis)
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10 pages, 14221 KiB  
Interesting Images
Multiple Pulmonary Involvement in the Rapidly Progressive Evolution of Rheumatoid Arthritis
by Beatrice Mahler, Mădălina Ioana Moșteanu, Raluca Bobocea, Iris Negoescu, Leonard Florentin Mircea, Adrian Tudor, Maria Teodora Bogdan, Alina Croitoru and Angela Stefania Marghescu
Diagnostics 2024, 14(19), 2175; https://doi.org/10.3390/diagnostics14192175 - 29 Sep 2024
Cited by 1 | Viewed by 645
Abstract
A 66-year-old man, a 40-year smoker, was diagnosed with rheumatoid arthritis in 2018. He was treated for one year with methotrexate, and, later in 2020, he was diagnosed with interstitial pulmonary fibrosis. In 2022, treatment with nintedanib was initiated, with clinical improvement being [...] Read more.
A 66-year-old man, a 40-year smoker, was diagnosed with rheumatoid arthritis in 2018. He was treated for one year with methotrexate, and, later in 2020, he was diagnosed with interstitial pulmonary fibrosis. In 2022, treatment with nintedanib was initiated, with clinical improvement being indicated but without showing a functional or imaging benefit. The evolution of the disease was rapidly progressive and unfavorable, with death occurring due to pulmonary thromboembolism. Following the autopsy, triple lesions of the RA at the lung level were confirmed: interstitial, of the NSIP type with a fibrosing character at the level of the lower airways of the bilateral bronchiectasis type, and vascular damage due to pulmonary thromboembolism secondary to chronic inflammation. Full article
(This article belongs to the Special Issue Imaging of Rheumatoid Arthritis)
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