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Diagnostics
Special Issues
Diagnostic and Therapeutic Approaches to Corneal and Retinal Diseases
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Diagnostic and Therapeutic Approaches to Corneal and Retinal Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 754

Special Issue Editor

Dr. Caterina Gagliano

E-Mail Website
Guest Editor
Department of Medicine and Surgery, “Kore” University of Enna, 94100 Enna, Italy
Interests: ophthalmology; ocular immunology; rare diseases; pharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue "Diagnostic and Therapeutic Approaches to Corneal and Retinal Diseases" focuses on the diagnosis and treatment of corneal and retinal diseases. The cornea and the retina are two key parts of the eye. They are each responsible for different functions of the eye. For example, the cornea maintains the transparency of the eye and helps focus light, while the retina converts light signals into nerve signals and then transmits them to the brain to form vision. By bringing together the latest results of ophthalmologists and researchers from around the world, this Special Issue aims to provide valuable reference information for ophthalmologists, researchers and patients, promote academic exchanges and cooperation in the field of cornea and retinal diseases, and promote new progress in the prevention and treatment of related diseases.

The content of this Special Issue will cover but not be limited to the following aspects: the pathophysiological mechanisms of corneal diseases, the application of new diagnostic technologies, the exploration of innovative treatment strategies, research on the etiology of retinal diseases, the optimization of early diagnostic methods, the innovation of treatment technologies, etc. I look forward to providing a more comprehensive and in-depth perspective on the diagnosis and treatment of corneal and retinal diseases through this Special Issue.

Dr. Caterina Gagliano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • corneal diseases
  • retinal diseases
  • diagnostic technology
  • OCT
  • treatment

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Published Papers (1 paper)

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Research

12 pages, 2394 KiB  
Article
The Role of Pentacam Random Forest Index in Detecting Subclinical Keratoconus in a Chinese Cohort
by Yan Liu, Yu Zhang, Yuexin Wang, Ruilan Dong and Yueguo Chen
Diagnostics 2024, 14(20), 2304; https://doi.org/10.3390/diagnostics14202304 - 17 Oct 2024
Viewed by 579
Abstract
Purpose: This study aimed to evaluate the diagnostic accuracy of a novel shape index, the Pentacam Random Forest Index (PRFI), in detecting keratoconus (KC), specifically subclinical keratoconus, in Chinese refractive surgery candidates. Methods: This prospective cohort study included 856 participants who were divided [...] Read more.
Purpose: This study aimed to evaluate the diagnostic accuracy of a novel shape index, the Pentacam Random Forest Index (PRFI), in detecting keratoconus (KC), specifically subclinical keratoconus, in Chinese refractive surgery candidates. Methods: This prospective cohort study included 856 participants who were divided into four groups based on their tomographic outcomes: the KC group (n = 137), the very asymmetric ectasia (VAE) group (n = 73), the normal cornea group (n = 363) and the tomographically suspected KC (TSK) group (n = 283). The diagnostic performance of PRFI and other widely used indices, including the shape index BAD-D and the combined index TBI, was assessed using receiver operating characteristic (ROC) curve analysis and compared using DeLong’s test. The area under the curve (AUC), best cutoff values, and Youden index for each parameter are reported. Additionally, the false-positive rates of BAD-D and PRFI were calculated and compared in “normal corneas”. Results: All shape and biomechanical parameters collected in this study were found to be significantly different among the four groups (KC, VAE, TSK, and normal groups; p = 0.000). The AUC of PRFI was the highest in detecting any form of KC (including clinical KC eyes and VAE-NT eyes) in Chinese refractive surgery candidates, outperforming the widely used shape index BAD-D (0.919 vs. 0.890, p < 0.001). There was no significant difference in performance between the PRFI and the combined TBI index (0.919 vs. 0.916, p > 0.05). For detecting subclinical KC eyes (i.e., VAE-NT), the AUC of PRFI was 0.774, which was statistically comparable to TBI (0.774 vs. 0.776, p > 0.05), while outperforming BAD-D (0.774 vs. 0.684, p < 0.001). The best cutoff values of PRFI for detecting any KC and VAE-NT eyes were determined to be 0.37 and 0.27, respectively. Additionally, PRFI demonstrated a lower false-positive rate than BAD-D (13.8% vs. 43.8%, p < 0.001). Notably, the relatively high false-positive rate of BAD-D observed in this study might be attributed to the smaller horizontal corneal diameter in tomographically suspected eyes. Conclusions: The PRFI proved to be a superior shape index compared to BAD-D in detecting any form of keratoconus, including subclinical cases, in Chinese refractive surgery candidates. This finding may be attributed to the relatively small corneas commonly observed in Asians. Full article
(This article belongs to the Special Issue Diagnostic and Therapeutic Approaches to Corneal and Retinal Diseases)
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