Cellular and Molecular Mechanisms in Sensory–Metabolic Integration: From Signaling Pathways to Systemic Regulation

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 819

Special Issue Editors


E-Mail Website
Guest Editor
Department of Medicine and Surgery, “Kore” University of Enna, 94100 Enna, Italy
Interests: molecular biology of sensory systems; retinal cell biology; neurovascular biology; cellular signaling in metabolic diseases; oxidative stress and cell death mechanisms; experimental models of sensory disorders; cell-matrix Interactions; neuroprotection and cellular metabolism

E-Mail Website
Guest Editor
Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy, University of Monastir, Avicenne Street, Monastir 5019, Tunisia
Interests: reperfusion Injury; rat Liver

E-Mail Website
Guest Editor
Department of Medicine and Surgery, “Kore” University of Enna, 94100 Enna, Italy
Interests: ophthalmology; ocular immunology; rare diseases; pharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are now pleased to announce a Special Issue focusing on the fundamental biological mechanisms underlying sensory–metabolic integration at cellular and molecular levels. This Special Issue will seek to explore the basic science behind how cells and organisms coordinate sensory inputs with metabolic processes, from signal transduction to systemic regulation. This Special Issue welcomes original research articles, reviews, and case studies that investigate the following areas:

  • Mechanisms linking metabolic dysfunction to multisensory disorders;
  • The impact of metabolic syndrome on vision, hearing, balance, taste, smell, and somatosensation;
  • Neurometabolic pathways in the development of sensory impairments;
  • Novel diagnostic approaches for the early detection of sensory complications in metabolic disorders;
  • The role of sensory systems in metabolic regulation and energy homeostasis;
  • Therapeutic strategies targeting both metabolic and sensory dysfunctions;
  • Long-term outcomes and quality of life in patients with coexisting metabolic and sensory disorders;
  • Genetic and epigenetic factors influencing both metabolic and sensory health;
  • The influence of lifestyle factors on metabolic–sensory interactions;
  • Innovative technologies for monitoring and managing metabolic–sensory health.

By bringing together research on these interconnected topics, we aim to foster a better understanding of the complex relationships between metabolic dysfunction, multisensory disorders, and overall systemic health. This knowledge will be crucial for improving patient care and developing integrative approaches to health management across various medical fields, including endocrinology, neurology, otolaryngology, and internal medicine.

Dr. Antonino Maniaci
Dr. Giovanni Giurdanella
Dr. Mohamed Amin Zaoual
Dr. Caterina Gagliano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multisensory disorders
  • metabolic dysfunction
  • systemic health
  • sensory impairments
  • metabolic syndrome
  • neurometabolic pathways
  • vision impairment
  • hearing loss
  • vestibular disorders
  • olfactory dysfunction
  • gustatory dysfunction
  • somatosensory impairment
  • energy homeostasis
  • integrative medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

17 pages, 3883 KiB  
Article
Molecular Mechanisms Underlying Substance Transport, Signal Transduction, and Anti-Stress Regulation, as Well as Anti-Alkaline Regulation via Bursicon in the Cerebral Ganglion of Chinese Mitten Crab Eriocheir sinensis Under Alkaline Stress
by Meiyao Wang, Jun Zhou, Jiachun Ge, Gangchun Xu and Yongkai Tang
Biology 2025, 14(1), 84; https://doi.org/10.3390/biology14010084 - 16 Jan 2025
Viewed by 626
Abstract
(1) Background: Global climate change is intensifying, and the vigorous development and utilization of saline–alkali land is of great significance. As an important economic aquatic species in the context of saline–alkali aquaculture, it is highly significant to explore the regulatory mechanisms of Eriocheir [...] Read more.
(1) Background: Global climate change is intensifying, and the vigorous development and utilization of saline–alkali land is of great significance. As an important economic aquatic species in the context of saline–alkali aquaculture, it is highly significant to explore the regulatory mechanisms of Eriocheir sinensis under alkaline conditions. In particular, the brain (cerebral ganglion for crustaceans) serves as a vital regulatory organ in response to environmental stress; (2) Methods: In this study, a comparative transcriptome approach was employed to investigate the key regulatory genes and molecular regulatory mechanisms in the cerebral ganglion of E. sinensis under alkaline stress. (3) Results: The results demonstrated that the cerebral ganglion of E. sinensis exhibited a positive response to acute alkaline stress. Pathways associated with signal transduction and substance transportation, such as “phagosome” and “regulation of actin cytoskeleton”, along with regulatory genes involved in antioxidation, were upregulated synergistically to maintain homeostasis under alkaline stress. Furthermore, it was discovered for the first time that bursicon plays a positive regulatory role in the adaptation of E. sinensis to alkalinity. (4) Conclusions: The present study elucidates the molecular regulatory pattern of the cerebral ganglion in E. sinensis under acute alkaline stress as well as revealing a novel role of bursicon in facilitating adaptation to alkalinity in E. sinensis, providing valuable theoretical insights into the molecular regulatory mechanisms underlying the responses of cerebral ganglia to saline–alkali environments. These findings also offer a theoretical reference for promoting the sustainable development of the E. sinensis breeding industry under saline–alkali conditions. Full article
Show Figures

Figure 1

Back to TopTop