The Starting Point of Intestinal Microecological Regulation: Probiotics, Prebiotics, Synbiotics and Postbiotics and Their Associated Roles

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Microbiology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 596

Special Issue Editors


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State Key Laboratory of Food Science and Resources, Engineering Research Center for Biomass Conversion, Ministry of Education, Nanchang University, Nanchang 330047, China
Interests: functional food; microalgae food; biomass conversion; ecological engineering
Special Issues, Collections and Topics in MDPI journals
State Key Laboratory of Food Science and Resources, Engineering Research Center for Biomass Conversion, Ministry of Education, Nanchang University, Nanchang 330047, China
Interests: agro-industrial waste; biomass valorisation; value-added products; polysaccharide; integrated microbial bioprocess; anaerobic digestion; value-added biocompounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, cardiovascular and cerebrovascular diseases, metabolic syndrome, and other chronic diseases caused by dietary imbalance occur frequently. The gut microbiota is a target for many diseases. Many studies have revealed that probiotics, prebiotics, Biostime, and epigenetics play an important role in promoting the regulation of intestinal flora and maintaining host health. Probiotics include Lactobacillus, Bifidobacterium, Enterococcus, Bacillus, Clostridium, and yeast. Prebiotics include but are not limited to polysaccharides, oligosaccharides, dietary fiber, resistant starch, sugar alcohols, polyphenols, flavonoids, carotenoids, vitamins, glucosinolates, phytosterols, saponins, bioactive peptides, polyunsaturated fatty acids, etc. On the other hand, synbiotics are a mixture of living microbes and substrates, including probiotics and prebiotics. Postbiotics are mainly the isolated cell structure and secretion products or metabolic by-products collected after the release or lysis of living bacterial cells, including short-chain fatty acids, various bacteriocins, vitamins, peptides, microbial cell lysates, extracellular polysaccharides, etc. Nevertheless, the mechanism by which different probiotic and prebiotic combinations interact in the host remains largely unclear. Can the role of probiotics or prebiotics in regulating intestinal microecology be attributed to the epigenesis that occurs after the administration of probiotics or prebiotics, or is it a direct effect of the probiotics or prebiotics themselves? This aspect still needs further study. Based on the above conclusions, this Special Issue explores the correlation (mechanism) between various probiotics, prebiotics, synbiotics, and postbiotics that regulate intestinal microecology, laying a theoretical foundation for their precise customization and scientific formulation construction in health food.

Prof. Dr. Yuhuan Liu
Dr. Xian Cui
Guest Editors

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Keywords

  • probiotics
  • prebiotics
  • synbiotics
  • postbiotics
  • functional foods
  • gut microbiota regulation

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Published Papers (1 paper)

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Research

16 pages, 2226 KiB  
Article
Modulation of Serum Metabolic Profiles by Bifidobacterium breve BBr60 in Obesity: A Randomized Controlled Trial
by Ying Wu, Dejiao Gao, Yujia Pan, Yao Dong, Zhouya Bai and Shaobin Gu
Foods 2024, 13(22), 3655; https://doi.org/10.3390/foods13223655 - 17 Nov 2024
Viewed by 329
Abstract
Obesity, a prevalent metabolic disorder in youth, leads to complications and economic strain. Gut dysbiosis significantly contributes to obesity and metabolic issues. Bifidobacterium breve, a probiotic strain, may help regulate gut dysbiosis and benefit obese individuals. However, more research is needed on [...] Read more.
Obesity, a prevalent metabolic disorder in youth, leads to complications and economic strain. Gut dysbiosis significantly contributes to obesity and metabolic issues. Bifidobacterium breve, a probiotic strain, may help regulate gut dysbiosis and benefit obese individuals. However, more research is needed on its effect on serum metabolism. A total of 75 overweight or obese young adults (aged 19–45) participated in the current study, and were randomly divided into probiotic and placebo groups using a random number table. Both groups received dietary guidance and underwent twelve weeks of intervention with either oral Bifidobacterium breve BBr60 (BBr60) or a placebo. After the intervention, collection and analysis of fasting serum samples were conducted using mass spectrometry coupled with liquid chromatography. Analyses of associations were conducted in order to determine the correlations between key serum metabolites and clinical obesity indicators, aiming to understand the influence of BBr60. Due to 10 participants dropping out for personal reasons, the study included 32 and 33 participants in the placebo and the BBr60 groups, respectively. The BBr60 intervention significantly regulated 134 serum metabolites and influenced crucial metabolic pathways in obesity management (p < 0.05), including ascorbate and aldarate metabolism for oxidative stress reduction, cholesterol metabolism for lipid regulation, parathyroid hormone synthesis, secretion and action for the endocrine system, oxidative phosphorylation for enhanced energy efficiency, and glycolysis/gluconeogenesis for glucose metabolism. Analysis showed a positive relationship between fasting blood glucose (FBG), aspartate aminotransferase (AST), total protein (TP), and the content of 5-Methyl DL-glutamate (p < 0.05). Similarly, body mass index (BMI), weight, and body fat percentage (BFP) were positively linked to serum metabolites (1-Hydroxycyclohexyl) acetic acid, and 5-Oxooctanoic acid (p < 0.05). Significant associations of AST levels with key serum metabolites in cholesterol metabolism pathways further suggest BBr60’s potential to improve liver function and overall metabolic health in overweight or obese individuals. These findings support BBr60’s effectiveness in modulating serum metabolic profiles and suggest it may improve liver function and BMI in overweight or obese individuals by regulating key serum metabolites. Full article
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