Natural Products in Food: Chemical Structure, Extraction and Isolation, and Biological Activity

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 2573

Special Issue Editors

School of Food Science and Technology, Dalian Polytechnic University, No. 1, Qinggongyuan, Ganjingzi District, Dalian 116034, China
Interests: natural product chemistry; chemical database construction; extraction and isolation; structure elucidation and bioactivity evaluation; food analysis and quality control
School of Food Science and Technology, Dalian Polytechnic University, No. 1, Qinggongyuan, Ganjingzi District, Dalian 116034, China
Interests: active substance delivery; food preservation; food packaging
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Special Issue Information

Dear Colleagues,

Natural products, which are a class of secondary metabolites derived from plants, animals, and microorganisms, have become relevant functional food components. Due to their wide range of biological activity and low toxicity, natural products in food have become a popular topic for regulating health and preventing chronic diseases. The chemical structure, extraction and isolation and biological activity of the chemical constituents of food are of great significance to the research and development of functional and medicinal food.

The area of “natural products in food” is, thus, of great interest and is under ongoing investigation and constant innovation.

For this reason, this Special Issue of Foods is focused on the chemical analysis, chemical database construction, rapid extraction and isolation technology of active chemical constituents of foods. At the same time, various experimetal and computeral approaches used for the active evaluation of natural products in food will also be presented. In this Special Issue, original research articles and reviews are welcome.

Potential topics include, but are not limited to, the following:

  • Chemical analysis and database construction, including flavonoids, polyphenol, saponin, and carotenoids;
  • Novel extraction methods, including ultrasonic- or microwave-assisted exaction, and solid-phase extraction;
  • Rapid isolation technology, including 2D or 3D chromatography, supercritical fluid chromatography, and countercurrent chromatography;
  • Bioactivity evaluation and application, including anti-oxidant, anti-tumor, anti-diabetes, and antibacterial activities;
  • Drug discovery and active mechanisms, including bioinformatics and network analysis, in vitro and in vivo methods.

Dr. Yan Ding
Dr. Jingran Bi
Guest Editors

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Keywords

  • chemical analysis
  • structure elucidation
  • database construction
  • novel extraction
  • rapid isolation
  • bioactivity evaluation
  • active mechanism

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Published Papers (1 paper)

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Research

19 pages, 7608 KiB  
Article
Investigation of the Potential Phlorotannins and Mechanism of Six Brown Algae in Treating Type II Diabetes Mellitus Based on Biological Activity, UPLC-QE-MS/MS, and Network Pharmacology
by Jialiang Chen, Zheng Zhou, Ping Li, Shuhong Ye, Wei Li, Ming Li, Lin Zhu and Yan Ding
Foods 2023, 12(16), 3000; https://doi.org/10.3390/foods12163000 - 9 Aug 2023
Cited by 6 | Viewed by 1743
Abstract
Type 2 diabetes mellitus (T2DM) has developed into an important health concern worldwide. The discovery of phlorotannins and their efficacy in the treatment of T2DM has become a hotspot for research in various fields. In this study, the potential phlorotannins and mechanism of [...] Read more.
Type 2 diabetes mellitus (T2DM) has developed into an important health concern worldwide. The discovery of phlorotannins and their efficacy in the treatment of T2DM has become a hotspot for research in various fields. In this study, the potential phlorotannins and mechanism of six brown algae against T2DM were in-depth investigated using biological activity assays, LC-MS, and network pharmacology. First, the ethyl acetate fraction (EA frac.) showed high polyphenolic content and possessed significantly antioxidant and enzyme inhibitory abilities. Further, a total of fifty-nine peaks were obtained from six EA fracs. via UPLC-QE-MS/MS analysis, and fifteen of them were identified as phlorotannins and their isomers or derivatives. In detail, the chemical structures of six phlorotannins were inferred as dibenzodioxine-1,3,6,8-tetraol, bifuhalol, dioxinodehydroeckol, eckol, fucofurodiphlorethol, and fucotriphlorethol; three phlorotannin isomers were deduced to be fucophlorethol, trifucol, triphlorethol A, or triphlorethol B; and the phlorotannin derivative of m/z 263 was determined to be dibenzodioxine-1,2,3,6,8-pentanol or dibenzodioxine-1,2,4,5,7-pentanol. Moreover, 43 T2DM-related targets acted on by these chemicals were identified, and the function of phlorotannin to prevent and treat T2DM was elucidated in a holistic way based on the established compound-target-disease network, and GO function and KEGG pathway enrichment analysis. Full article
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