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Genetic Basis of Psoriasis
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Genetic Basis of Psoriasis

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: closed (15 June 2020) | Viewed by 9734

Special Issue Editors

Prof. Dr. Lam Tsoi

E-Mail Website
Guest Editor
1. Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
2. Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
3. Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
Interests: inflammatory skin diseases; genetics and genomics; systems biology; translational bioinformatics
Dr. Matthew Patrick

E-Mail Website
Guest Editor
Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Interests: translational bioinformatics, biological inference, high dimensional biological data, dermatological research

Special Issue Information

Dear Colleagues,

Psoriasis is a multifactorial disease with a complex genetic architecture. Genetics and genomics studies facilitated by high throughput techniques have significantly advanced the identification of disease components, highlighting >80 disease susceptibility regions and >4000 genes being dysregulated in lesional skin. It is important to leverage these resources to understand how the disease-associated factors can contribute, either individually or combined, to psoriasis pathology. It is also critical to understand how the variations of these components may associate with disease heterogeneity, including differential disease manifestation and clinical outcomes. In this Special Issue, we will compile a collection of work aiming towards the development of personalized medicine for psoriatic patients, and we welcome reviews, new methods, and original articles that explore the identification and interpretation of psoriasis-associated factors. These include efforts that can advance the understanding of the disease by unraveling the involved molecular mechanisms, as well as work that takes advantage of multi-omics datasets (genetics, epigenetics, gene expression, health records etc.) or uses novel techniques to enhance data integration and interpretation.

Prof. Lam Tsoi
Dr. Matthew Patrick
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Psoriasis
  • Genetics
  • Autoimmune
  • Genomics
  • Multi-omics
  • Systems biology

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Published Papers (2 papers)

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Research

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10 pages, 496 KiB  
Article
Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population
by Omar Graciano-Machuca, Anabell Alvarado-Navarro, María Guadalupe Ramírez-Dueñas, Delfina Guadalupe Villanueva-Quintero, Erandi Enif Velarde-de la Cruz, Andrea Carolina Machado-Sulbarán, Margarita Montoya-Buelna and Pedro Ernesto Sánchez-Hernández
Genes 2020, 11(3), 338; https://doi.org/10.3390/genes11030338 - 22 Mar 2020
Cited by 3 | Viewed by 3346
Abstract
NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating KIR genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association [...] Read more.
NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating KIR genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association between KIR/HLA genes and genotypes with PsV in the Western mestizo Mexican population. One hundred subjects diagnosed with PsV (SP) and 108 healthy subjects (HS) were genotyped for 14 KIR genes, HLA-Bw4, HLA-C1, and HLA-C2 by PCR-single specific primer (SSP). Positive associations of the KIR3DS1 gene (odds ratio (OR) 1.959, p = 0.021), G11 genotype (OR 19.940, p = 0.008), and KIR3DS1/HLA-ABw4 (OR 2.265, p = 0.009) were found with susceptibility to PsV. In contrast, the G1 genotype (OR 0.448, p = 0.031) and KIR3DL1/HLA-Bw4Ile80 (OR 0.522, p = 0.022) were negatively associated with susceptibility to this disease. These results suggest an implication of the KIR3DS1/HLA-ABw4 genotype in PsV pathology. Full article
(This article belongs to the Special Issue Genetic Basis of Psoriasis)
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Review

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22 pages, 310 KiB  
Review
Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis
by Geneviève Rioux, Zainab Ridha, Mélissa Simard, Florence Turgeon, Sylvain L. Guérin and Roxane Pouliot
Genes 2020, 11(10), 1155; https://doi.org/10.3390/genes11101155 - 30 Sep 2020
Cited by 35 | Viewed by 5940
Abstract
Psoriasis is an immune-mediated inflammatory skin disease with a complex etiology involving environmental and genetic factors. A better insight into related genomic alteration helps design precise therapies leading to better treatment outcome. Gene expression in psoriasis can provide relevant information about the altered [...] Read more.
Psoriasis is an immune-mediated inflammatory skin disease with a complex etiology involving environmental and genetic factors. A better insight into related genomic alteration helps design precise therapies leading to better treatment outcome. Gene expression in psoriasis can provide relevant information about the altered expression of mRNA transcripts, thus giving new insights into the disease onset. Techniques for transcriptome analyses, such as microarray and RNA sequencing (RNA-seq), are relevant tools for the discovery of new biomarkers as well as new therapeutic targets. This review summarizes the findings related to the contribution of keratinocytes in the pathogenesis of psoriasis by an in-depth review of studies that have examined psoriatic transcriptomes in the past years. It also provides valuable information on reconstructed 3D psoriatic skin models using cells isolated from psoriatic patients for transcriptomic studies. Full article
(This article belongs to the Special Issue Genetic Basis of Psoriasis)
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