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Regulation of Inflammatory Reactions in Health and Disease 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1515

Special Issue Editors


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Guest Editor
Internal Medicine E Department, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Interests: adhesiveness; C-reactive protein; erythrocyte aggregation; leukocytes; inflammation; fibrinogen; leukocyte count; erythrocytes
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Departments of Internal Medicine "C", "D" & "E", Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, Israel
Interests: inflammation; stress; regulation; acetylcholinesterase
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the COVID-19 pandemic still unraveling and affecting millions of individuals worldwide, understanding uncontrolled inflammatory reactions has become an urgent need.

Regardless of the cause, inflammation has evolved as an adaptive response for restoring homeostasis. However, inflammatory response is a double-edged sword as excessive inflammation can itself exacerbate tissue damage. To limit unfavorable consequences, many stimuli that trigger inflammatory response simultaneously trigger a program that actively resolves inflammation. Nonresolving inflammation is associated with adverse outcomes and is regarded as a major driver of disease in chronic conditions. Multiple mechanisms normally ensure resolution, involving genetic, transcriptional, post-transcriptional, and behavioral pathways.

As volumes 1 and 2 of the Special Issue “Regulation of Inflammatory Reactions in Health and Disease” were successful, we have chosen to reopen this Special Issue in the International Journal of Molecular Sciences (ISSN 1422-0067, IF 6.208, JCR Category Q1). This third Special Issue, “Regulation of Inflammatory Reactions in Health and Disease 3.0”, welcomes original manuscripts and review articles addressing this pressing topic.

Prof. Dr. Shlomo A. Berliner
Dr. Shani Shenhar-Tsarfaty
Guest Editors

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Keywords

  • inflammation
  • molecular mechanism
  • healthy ageing
  • genetic, transcriptional, and post-transcriptional mechanisms
  • sex difference
  • cardiovascular, rheumatic diseases
  • COVID-19
  • cholinesterase

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Published Papers (1 paper)

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Review

29 pages, 6856 KiB  
Review
Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option?
by Shania Bieri, Burkhard Möller and Jennifer Amsler
Int. J. Mol. Sci. 2024, 25(15), 8212; https://doi.org/10.3390/ijms25158212 - 27 Jul 2024
Viewed by 1053
Abstract
Ferroptosis is a form of iron-dependent regulated cell death caused by the accumulation of lipid peroxides. In this review, we summarize research on the impact of ferroptosis on disease models and isolated cells in various types of arthritis. While most studies have focused [...] Read more.
Ferroptosis is a form of iron-dependent regulated cell death caused by the accumulation of lipid peroxides. In this review, we summarize research on the impact of ferroptosis on disease models and isolated cells in various types of arthritis. While most studies have focused on rheumatoid arthritis (RA) and osteoarthritis (OA), there is limited research on spondylarthritis and crystal arthropathies. The effects of inducing or inhibiting ferroptosis on the disease strongly depend on the studied cell type. In the search for new therapeutic targets, inhibiting ferroptosis in chondrocytes might have promising effects for any type of arthritis. On the other hand, ferroptosis induction may also lead to a desired decrease of synovial fibroblasts in RA. Thus, ferroptosis research must consider the cell-type-specific effects on arthritis. Further investigation is needed to clarify these complexities. Full article
(This article belongs to the Special Issue Regulation of Inflammatory Reactions in Health and Disease 3.0)
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