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Extracellular Vesicles: The Biology and Therapeutic Applications, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 2229

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Guest Editor
Department of Genetics, Cell- and Immunobiology, Semmelweis University, H-1089 Budapest, Hungary
Interests: EV biology; EV release; uptake and intracellular distribution; biomarker research and EV based technology development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to publish a research article, review, short communication, or technical report in a Special Issue on “Extracellular Vesicles: The Biology and Therapeutic Applications, 2nd Edition”.

Extracellular vesicles (EVs) are particles limited to the phospholipid bilayer and located in the extracellular space, without self-reproducibility. They represent a heterogeneous population in size and origin and play an important role in physiology and pathology. The exponentially increased number of published studies in the last decade highlights the importance of the field; however, many EV-related questions remain unanswered, while the exact role of different EV populations in cell-to-cell communication is still not completely understood. The release mechanism, uptake, and intracellular fate of EVs are not fully understood. High-throughput methods such as proteomics, transcriptomics, lipidomics, glycomics, and glycoproteomics often lead to new EV-related biomarkers and may suggest new targets in diagnostics. EV-based therapies are a new and dynamically increasing aspect of biomedical sciences.

Due to the increased scientific interest, the EV research community has invested huge efforts in the standardization of EV-based techniques (MISEV2014, MISEV2018, and the MISEV 2023), while the applied technologies are far from fully evolved, and further essential developments are needed.

This Special Issue aims to gather manuscripts on the basic understanding of EV-related biological processes, new technologies supporting EV studies, biomarker research, and therapeutic applications.

We look forward to receiving your contributions.

Dr. Tamás Visnovitz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles (EVs)
  • exosomes
  • release
  • uptake
  • bio-distribution
  • methods
  • biomarkers
  • therapeutic applications

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Published Papers (1 paper)

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Review

18 pages, 1059 KiB  
Review
Therapeutic Potential of Bovine Milk-Derived Extracellular Vesicles
by Madhusha Prasadani, Suranga Kodithuwakku, Georgia Pennarossa, Alireza Fazeli and Tiziana A. L. Brevini
Int. J. Mol. Sci. 2024, 25(10), 5543; https://doi.org/10.3390/ijms25105543 - 19 May 2024
Cited by 1 | Viewed by 1899
Abstract
Milk is a fundamental component of the human diet, owing to its substantial nutritional content. In addition, milk contains nanoparticles called extracellular vesicles (EVs), which have indicated their potential beneficial roles such as cell-to-cell communication, disease biomarkers, and therapeutics agents. Amidst other types [...] Read more.
Milk is a fundamental component of the human diet, owing to its substantial nutritional content. In addition, milk contains nanoparticles called extracellular vesicles (EVs), which have indicated their potential beneficial roles such as cell-to-cell communication, disease biomarkers, and therapeutics agents. Amidst other types of EVs, milk EVs (MEVs) have their significance due to their high abundance, easy access, and stability in harsh environmental conditions, such as low pH in the gut. There have been plenty of studies conducted to evaluate the therapeutic potential of bovine MEVs over the past few years, and attention has been given to their engineering for drug delivery and targeted therapy. However, there is a gap between the experimental findings available and clinical trials due to the many challenges related to EV isolation, cargo, and the uniformity of the material. This review aims to provide a comprehensive comparison of various techniques for the isolation of MEVs and offers a summary of the therapeutic potential of bovine MEVs described over the last decade, analyzing potential challenges and further applications. Although a number of aspects still need to be further elucidated, the available data point to the role of MEVs as a potential candidate with therapeutics potential, and the supplementation of MEVs would pave the way to understanding their in-depth effects. Full article
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