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The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 3464

Special Issue Editor

Dr. Eugenia Piragine

E-Mail Website
Guest Editor
Department of Pharmacy, University of Pisa, via Bonanno, 6, 56121 Pisa, Italy
Interests: cardiovascular pharmacology; gasotransmitters; hydrogen sulfide (H2S); meta-analysis; systematic review
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Sulfur metabolism plays a central role in redox biochemistry and tissue homeostasis in humans. Increasing evidence indicates an imbalance in sulfur metabolism in many diseases, from cardiovascular to metabolic disorders. Therefore, the use of sulfur compounds is emerging as a possible therapeutic strategy to restore the balance of sulfur metabolism, preserve human health and slow the progression of disease. Of note, some sulfur compounds can act as hydrogen sulfide (H2S) donors. This is an intriguing aspect of the pharmacology of sulfur compounds. In fact, the gasotransmitter H2S exhibits a plethora of beneficial effects: it enhances the endogenous antioxidant defense system, counteracts the inflammatory process, promotes vasorelaxation, and slows cellular senescence. This Special Issue aims to evaluate the role of sulfur compounds in human health and diseases to support a possible clinical use of natural and synthetic sulfur compounds in the prevention and treatment of multiple pathological conditions.

Dr. Eugenia Piragine
Guest Editor

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Keywords

  • sulfur compounds
  • sulfur metabolism
  • hydrogen sulfide
  • H2S-donors
  • human health
  • human disease
  • nutraceuticals

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Published Papers (2 papers)

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Research

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21 pages, 2675 KiB  
Article
The Anticancer Effects of the Garlic Organosulfide Diallyl Trisulfide through the Attenuation of B[a]P-Induced Oxidative Stress, AhR Expression, and DNA Damage in Human Premalignant Breast Epithelial (MCF-10AT1) Cells
by Dominique T. Ferguson, Equar Taka, Syreeta L. Tilghman, Tracy Womble, Bryan V. Redmond, Shasline Gedeon, Hernan Flores-Rozas, Sarah L. Reed, Karam F. A. Soliman, Konan J. W. Kanga and Selina F. Darling-Reed
Int. J. Mol. Sci. 2024, 25(2), 923; https://doi.org/10.3390/ijms25020923 - 11 Jan 2024
Cited by 2 | Viewed by 1700
Abstract
Benzo[a]pyrene (B[a]P) is the most characterized polycyclic aromatic hydrocarbon associated with breast cancer. Our lab previously reported that the organosulfur compound (OSC), diallyl trisulfide (DATS), chemoprevention mechanism works through the induction of cell cycle arrest and a reduction in oxidative stress and DNA [...] Read more.
Benzo[a]pyrene (B[a]P) is the most characterized polycyclic aromatic hydrocarbon associated with breast cancer. Our lab previously reported that the organosulfur compound (OSC), diallyl trisulfide (DATS), chemoprevention mechanism works through the induction of cell cycle arrest and a reduction in oxidative stress and DNA damage in normal breast epithelial cells. We hypothesize that DATS will inhibit B[a]P-induced cancer initiation in premalignant breast epithelial (MCF-10AT1) cells. In this study, we evaluated the ability of DATS to attenuate B[a]P-induced neoplastic transformation in MCF-10AT1 cells by measuring biological endpoints such as proliferation, clonogenicity, reactive oxygen species (ROS) formation, and 8-hydroxy-2-deoxyguanosine (8-OHdG) DNA damage levels, as well as DNA repair and antioxidant proteins. The results indicate that B[a]P induced proliferation, clonogenic formation, ROS formation, and 8-OHdG levels, as well as increasing AhR, ARNT/HIF-1β, and CYP1A1 protein expression compared with the control in MCF-10AT1 cells. B[a]P/DATS’s co-treatment (CoTx) inhibited cell proliferation, clonogenic formation, ROS formation, AhR protein expression, and 8-OHdG levels compared with B[a]P alone and attenuated all the above-mentioned B[a]P-induced changes in protein expression, causing a chemopreventive effect. This study demonstrates, for the first time, that DATS prevents premalignant breast cells from undergoing B[a]P-induced neoplastic transformation, thus providing more evidence for its chemopreventive effects in breast cancer. Full article
(This article belongs to the Special Issue The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases)
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Review

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27 pages, 6486 KiB  
Review
Pills of Multi-Target H2S Donating Molecules for Complex Diseases
by Angela Corvino, Antonia Scognamiglio, Ferdinando Fiorino, Elisa Perissutti, Vincenzo Santagada, Giuseppe Caliendo and Beatrice Severino
Int. J. Mol. Sci. 2024, 25(13), 7014; https://doi.org/10.3390/ijms25137014 - 27 Jun 2024
Cited by 1 | Viewed by 1193
Abstract
Among the various drug discovery methods, a very promising modern approach consists in designing multi-target-directed ligands (MTDLs) able to modulate multiple targets of interest, including the pathways where hydrogen sulfide (H2S) is involved. By incorporating an H2S donor moiety [...] Read more.
Among the various drug discovery methods, a very promising modern approach consists in designing multi-target-directed ligands (MTDLs) able to modulate multiple targets of interest, including the pathways where hydrogen sulfide (H2S) is involved. By incorporating an H2S donor moiety into a native drug, researchers have been able to simultaneously target multiple therapeutic pathways, resulting in improved treatment outcomes. This review gives the reader some pills of successful multi-target H2S-donating molecules as worthwhile tools to combat the multifactorial nature of complex disorders, such as inflammatory-based diseases and cancer, as well as cardiovascular, metabolic, and neurodegenerative disorders. Full article
(This article belongs to the Special Issue The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases)
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