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Paradox of Salmonella Survival and Host Defense Strategies
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Paradox of Salmonella Survival and Host Defense Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 1480

Special Issue Editors

Prof. Dr. John Hwa Lee

E-Mail Website
Guest Editor
College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of Korea
Interests: veterinary vaccines; delivery systems; Salmonella vectored vaccines; Salmonella in cancer therapy; oral mRNA vaccine; Salmonella pathophysiology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Amal Senevirathne

E-Mail Website
Guest Editor
College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of Korea
Interests: veterinary vaccines; delivery systems; Salmonella vector vaccines; Salmonella in cancer therapy; oral mRNA vaccine; Salmonella pathophysiology; Salmonella mediated immunotherapy; antibacterial-antiviral
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue delves into the intricate and paradoxical relationship between Salmonella pathogens and host defense mechanisms. It aims to explore the duality of Salmonella’s survival strategies amidst robust host immune responses. By bringing together cutting-edge research on molecular pathogenesis, host–pathogen interactions, and innovative therapeutic approaches, this issue seeks to provide a comprehensive understanding of the complex dance between Salmonella bacteria and the host’s immune system. Researchers and clinicians alike will find valuable insights into the latest advancements and unresolved questions in the dynamic field of Salmonella pathophysiology.

We hope you will join us in making this Special Issue a significant milestone in Salmonella research.

Prof. Dr. John Hwa Lee
Prof. Dr. Amal Senevirathne
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Salmonella
  • Salmonella serovars
  • virulence factors
  • host immune response
  • human health
  • animal health and poductivity
  • infection models

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Published Papers (2 papers)

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Research

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19 pages, 12008 KiB  
Article
Intracellular Survival and Pathogenicity Modulation of Salmonella Lon, CpxR, and RfaL Mutants Used as Live Bacterial Vectors under Abiotic Stress, Unveiling the Link between Stress Response and Virulence in Epithelial Cells
by Perumalraja Kirthika, Amal Senevirathne, Sungwoo Park, Ram Prasad Aganja, In-Shik Kim, Hyun-Jin Tae and John Hwa Lee
Int. J. Mol. Sci. 2024, 25(16), 9056; https://doi.org/10.3390/ijms25169056 - 21 Aug 2024
Viewed by 748
Abstract
In the current study, two Salmonella Typhimurium strains, JOL 912 and JOL 1800, were engineered from the wild-type JOL 401 strain through in-frame deletions of the lon and cpxR genes, with JOL 1800 also lacking rfaL. These deletions significantly attenuated the strains, [...] Read more.
In the current study, two Salmonella Typhimurium strains, JOL 912 and JOL 1800, were engineered from the wild-type JOL 401 strain through in-frame deletions of the lon and cpxR genes, with JOL 1800 also lacking rfaL. These deletions significantly attenuated the strains, impairing their intracellular survival and creating unique immunological profiles. This study investigates the response of these strains to various abiotic stress conditions commonly experienced in vivo, including temperature, acidity, osmotic, and oxidative stress. Notably, cold stress induced a non-significant trend towards increased invasion by Salmonella compared to other stressors. Despite the observed attenuation, no significant alterations in entry mechanisms (trigger vs. zipper) were noted between these strains, although variations were evident depending on the host cell type. Both strains effectively localized within the cytoplasm, demonstrating their ability to invade and interact with the intracellular environment. Immunologically, JOL 912 elicited a robust response, marked by substantial activation of nuclear factor kappa B (NF-kB), and chemokines, interleukin 8 (CXCL 8) and interleukin 10 (CXCL 10), comparable to the wild-type JOL 401 (over a fourfold increase compared to JOL 1800). In contrast, JOL 1800 exhibited a minimal immune response. Additionally, these attenuations influenced the expression of cyclins D1 and B1 and caspases 3 and 7, indicating cell cycle arrest at the G2/M phase and promotion of the G0/G1 to S phase transition, alongside apoptosis in infected cells. These findings provide valuable insights into the mechanisms governing the association, internalization, and survival of Salmonella mutants, enhancing our understanding of their regulatory effects on host cell physiology. Full article
(This article belongs to the Special Issue Paradox of Salmonella Survival and Host Defense Strategies)
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Review

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15 pages, 2017 KiB  
Review
Impact on Human Health of Salmonella spp. and Their Lipopolysaccharides: Possible Therapeutic Role and Asymptomatic Presence Consequences
by Mateusz Mikołajczyk, Dagmara Złotkowska and Anita Mikołajczyk
Int. J. Mol. Sci. 2024, 25(22), 11868; https://doi.org/10.3390/ijms252211868 - 5 Nov 2024
Viewed by 498
Abstract
Epidemiologically, one of the most important concerns associated with introducing Salmonella spp. into the environment and food chain is the presence of asymptomatic carriers. The oncogenic and oncolytic activity of Salmonella and their lipopolysaccharides (LPSs) is important and research on this topic is [...] Read more.
Epidemiologically, one of the most important concerns associated with introducing Salmonella spp. into the environment and food chain is the presence of asymptomatic carriers. The oncogenic and oncolytic activity of Salmonella and their lipopolysaccharides (LPSs) is important and research on this topic is needed. Even a single asymptomatic dose of the S. Enteritidis LPS (a dose that has not caused any symptoms of illness) in in vivo studies induces the dysregulation of selected cells and bioactive substances of the nervous, immune, and endocrine systems. LPSs from different species, and even LPSs derived from different serotypes of one species, can define different biological activities. The activity of low doses of LPSs derived from three different Salmonella serotypes (S. Enteritidis, S. Typhimurium, and S. Minnesota) affects the neurochemistry of neurons differently in in vitro studies. Studies on lipopolysaccharides from different Salmonella serotypes do not consider the diversity of their activity. The presence of an LPS from S. Enteritidis in the body, even in amounts that do not induce any symptoms of illness, may lead to unknown long-term consequences associated with its action on the cells and biologically active substances of the human body. These conclusions should be important for both research strategies and the pharmaceutical industry &. Full article
(This article belongs to the Special Issue Paradox of Salmonella Survival and Host Defense Strategies)
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