Chronic Obstructive Pulmonary Disease (COPD): From Pathogenesis to Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 December 2024 | Viewed by 2064
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chronic obstructive pulmonary disease (COPD) is a common syndrome of progressive airflow obstruction due to long-term inhalation of noxious substances. The pathology of COPD is characterized by emphysematous destruction of the lung and airways remodeling leading to airflow limitation. The pathogenesis of COPD is complex and heterogeneous and multiple mechanisms such as inflammation, oxidative stress and apoptosis. In addition, other factors such as genetic susceptibility, in utero events, preterm birth, recurrent respiratory infections, and exposure to air pollution also play a large part in the development of COPD.
To reduce the enormous disease burden of COPD, it is essential to clarify the pathogenesis of COPD, and to develop new personalized treatments. Now, medical management of COPD is largely limited to reduce symptom burden instead to use disease-modifying medicines now available for other degenerative diseases.
In this special issue of IJMS we want to be a vehicle for the publication of the best original research articles dealing with novel finding on genetics, environmental, infection, and other physio-pathogenic mechanism that promote COPD development. Articles reporting novel diagnostics techniques, disease management and natural history of the disease are also welcomed.
Topics include, but are not limited to, the following:
- Sex differences in COPD from biological mechanisms to therapy.
- Personalizing therapy in COPD
- Biomarkers of severity and biomarkers of progression of COPD
- Pathophysiological processes that lead to emphysema and/or chronic bronchitis
- Biological pathways that lead to different clinical presentations
Prof. Dr. José M. Marin
Guest Editor
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Keywords
- COPD
- COPD mechanisms
- COPD pathology
- COPD pharmacology
- cytokine biology
- biomarkers
- early diagnosis
- inflammation
- COPD management
- new therapies
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