Angiogenesis in Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 6222
Special Issue Editors
Interests: bioinorganic chemistry; coordination chemistry; neurochemistry; angiogenesis; metal ions; peptides
Special Issues, Collections and Topics in MDPI journals
Interests: neurochemistry; neurodegeneration; signaling: receptors interactions; receptor metabolism; life/death/differentiation signaling; traslocator protein
Special Issue Information
Dear Colleagues,
Angiogenesis is the physiological process by which new blood capillaries form from the existing vasculature.
Excessive angiogenesis has been implicated, directly or indirectly, in many disorders and among them cancer, autoimmune diseases, diabetic retinopathy, rheumatoid arthritis and atherosclerosis. Conversely, insufficient vascularization and inadequate blood vessel growth can underpin or contribute to cerebral ischemia, coronary heart disease and delayed wound healing.
Angiogenesis is a dynamic and complex process regulated by a very sensitive interplay of different growth factors and inhibitors; the maintenance of their correct balance is essential for the physiological control of blood vessel growth.
The interaction between neoplastic cells and newly formed vessels is one of the fundamental biological events involved in the growth of solid tumor growth and metastases formation. The so-called “angiogenic switch” is an alteration in the balance of pro-angiogenic and anti-angiogenic molecules, with an increase of activators, that can be determined by a local change in the tissue environment, such as hypoxia, low pH, injury, inflammation and metal ions dyshomeostasis.
Angiogenesis is also a prominent feature of brain aging and neurological diseases, either as a pathophysiological factor or as a response to injury. Most cases of Alzheimer’s disease have variable degrees of concomitant vascular pathology, including atherosclerosis, microvascular degeneration, blood–brain barrier dysfunction and cerebral amyloid angiopathy. The increased leakiness in the blood vessels disrupts the blood‐brain barrier and allows unwanted blood products to enter the brain causing the progression of disease pathology and promoting amyloid aggregation. Increased numbers of endothelial cell nuclei and blood vessels have been found postmortem in the substantia nigra of patients affected by Parkinson’s disease.
The interaction between cell growth factors as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), angiopoietin, platelet derived growth factor (PDGF), epidermal growth factor (EGF), angiogenin and their respective receptors constitutes one of the main targets for the design of new drugs in many pathologies,
As volume 1 of the Special Issue “Angiogenesis in Disease ” has been successful, we will be exploring this issue further in the International Journal of Molecular Sciences (ISSN 1422-0067, IF 5.924, JCR Category Q1). This second Special Issue focuses on the signaling pathways of activators and inhibitors of angiogenesis in pathological conditions as well as to new pharmacological approach based on anti- or pro-angiogenic therapies.
https://www.mdpi.com/journal/ijms/special_issues/Angiogenesis_disease
Dr. Diego La Mendola
Prof. Dr. Claudia Martini
Prof. Dr. Maria Letizia Trincavelli
Guest Editors
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Keywords
- blood vessels
- angiogenic factors
- trophic factors
- angiogenesis biomarkers
- signaling
- cancers
- neurodegeneration
- heart diseases
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