Non-Coding RNA: Biomarkers for Cardiovascular Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 644
Special Issue Editor
Special Issue Information
Dear Colleagues,
Non-coding RNAs (ncRNAs) are highly abundant RNA molecules that, although not translated into protein, play an important role in cellular processes. ncRNAs have the function of regulating gene expression at the transcriptional or post-transcriptional level. ncRNAs play essential roles in homeostasis, development, cell proliferation, differentiation, and apoptosis, as well as a wide variety of pathologies. There are several types of ncRNAs, and most of them are closely linked to epigenetic processes. ncRNAs are divided into two large groups: short non-coding RNAs with a length of less than 200nt, and long non-coding RNAs with a length of more than 200nt. Among these different types of short non-coding RNAs are microRNAs, Piwi-interacting RNAs, small interfering RNAs, small nuclear RNAs, small nucleolar RNAs, and circular RNAs. ncRNAs have been identified as being novel regulators of cardiovascular risk factors and may be important biomarker candidates for improving diagnostic and prognostic assessments in cardiovascular diseases. Furthermore, ncRNAs are emerging as novel therapeutic agents, thus providing new therapeutic targets, some of which are being used in clinical practice. In this Special Issue, we focus on the recent advances and approaches for the mechanisms of action and diagnostic or therapeutic uses of ncRNAs in cardiovascular diseases, such as atrial fibrillation, atherosclerosis, myocardial infarction, heart failure, or cardiotoxicity.
Dr. Isabel Moscoso
Guest Editor
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Keywords
- cardiovascular diseases
- non-coding RNA (ncRNA)
- therapeutics
- biomarkers
- microRNA
- lncRNA
- siRNA
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