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Recent Research of Natural Products from Microalgae and Cyanobacteria
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Recent Research of Natural Products from Microalgae and Cyanobacteria

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 2551

Special Issue Editor

Dr. Biswajita Pradhan

E-Mail Website
Guest Editor
1. Department of Biotechnology, Sangmyung University, Seoul 03016, Republic of Korea
2. Department of Botany, Model Degree College, Rayagada 765017, Odisha, India
Interests: microalgal and cyanobacterial natural products; isolation and characterization of bioactive compounds; phyto-chemicals; antioxidants; pharmaceuticals; nutraceuticals; therapeutical; anticancer; antidiabetic; antimicrobial; anti-inflammatory

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Recent Research of Natural Products from Microalgae and Cyanobacteria”, presents a comprehensive overview of the latest research advancements concerning the exploration of the diverse array of bioactive compounds. Microalgae and cyanobacteria are renowned for their vast biochemical diversity and their potential for producing valuable natural products. This Special Issue highlights the cutting-edge research exploring various aspects of microalgae and cyanobacteria, including cultivation techniques, isolation, and the characterization of bioactive compounds, as well as their potential applications in pharmaceutical, nutraceutical, cosmeceuticals, biofuels, and industrial fields. The Issue also focuses on elucidating the biological activities of crude extracts and identified compounds, including antioxidant, antibacterial, antiviral, antifungal, anticancer, antidiabetic, and anti-inflammatory activities. Through the collaboration of experts in the field, this Special Issue provides valuable insights into the potential of microalgae and cyanobacteria as sustainable sources of novel bioactive compounds, with diverse applications in biotechnology, medicine, therapeutics, and environmental sustainability.

Dr. Biswajita Pradhan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • marine and fresh water microalgal and cyanobacterial bioactive compounds
  • microalgal and cyanobacterial carotenoids, vitamins, phenolics, and phycobiliproteins
  • microalgal and cyanobacterial alkaloids
  • microalgal and cyanobacterial polysaccharides
  • microalgal and cyanobacterial peptides
  • microalgal and cyanobacterial polyphenols
  • microalgal and cyanobacterial antioxidants
  • microalgal and cyanobacterial pharmaceuticals
  • microalgal and cyanobacterial nutraceuticals
  • microalgal and cyanobacterial anti-inflammatory compounds
  • microalgal and cyanobacterial antimicrobial compounds
  • microalgal and cyanobacterial anticancer compounds
  • microalgal and cyanobacterial neuroprotective compounds
  • microalgal and cyanobacterial antiviral compounds
  • microalgal and cyanobacterial-derived anti-aging compounds
  • microalgal and cyanobacterial extracts

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Published Papers (2 papers)

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Research

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14 pages, 14978 KiB  
Article
Serum-Free Media Formulation Using Marine Microalgae Extracts and Growth Factor Cocktails for Madin-Darby Canine Kidney and Vero Cell Cultures
by Areumi Park, Yeon-Ji Lee, Eunyoung Jo, Gun-Hoo Park, Seong-Yeong Heo, Eun-Jeong Koh, Seung-Hong Lee, Seon-Heui Cha and Soo-Jin Heo
Int. J. Mol. Sci. 2024, 25(18), 9881; https://doi.org/10.3390/ijms25189881 - 12 Sep 2024
Viewed by 847
Abstract
The development of serum-free media (SFM) is critical to advance cell culture techniques used in viral vaccine production and address the ethical concerns and contamination risks associated with fetal bovine serum (FBS). This study evaluated the effects of marine microalgal extracts and growth [...] Read more.
The development of serum-free media (SFM) is critical to advance cell culture techniques used in viral vaccine production and address the ethical concerns and contamination risks associated with fetal bovine serum (FBS). This study evaluated the effects of marine microalgal extracts and growth factor cocktails on the activity of Madin-Darby canine kidney (MDCK) and Vero cells. Five marine microalgal species were used: Spirulina platensis (SP), Dunaliella salina (DS), Haematococcus pluvialis (HP), Nannochloropsis salina (NS), and Tetraselmis sp. (TS). DS and SP extracts significantly increased the proliferation rate of both MDCK and Vero cells. DS had a proliferation rate of 149.56% and 195.50% in MDCK and Vero cells, respectively, compared with that in serum-free medium (SFM). Notably, DS and SP extracts significantly increased superoxide dismutase (SOD) activity, which was 118.61% in MDCK cells and 130.08% in Vero cells for DS, and 108.72% in MDCK cells and 125.63% in Vero cells for SP, indicating a reduction in intracellular oxidative stress. Marine microalgal extracts, especially DS and SP, are feasible alternatives to FBS in cell culture as they promote cell proliferation, ensure safety, and supply essential nutrients while reducing oxidative stress. Full article
(This article belongs to the Special Issue Recent Research of Natural Products from Microalgae and Cyanobacteria)
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Review

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19 pages, 2774 KiB  
Review
Insufficient Acetyl-CoA Pool Restricts the Phototrophic Production of Organic Acids in Model Cyanobacteria
by Dawei You, Faiz Rasul, Tao Wang and Maurycy Daroch
Int. J. Mol. Sci. 2024, 25(21), 11769; https://doi.org/10.3390/ijms252111769 - 1 Nov 2024
Viewed by 560
Abstract
Cyanobacteria are promising biological chassis to produce biochemicals such as carboxylic acids and their derivatives from CO2. In this manuscript, we reflected on cyanobacterial acetyl-CoA pool and TCA cycle as an important source of precursor molecules for the biosynthesis of carboxylic [...] Read more.
Cyanobacteria are promising biological chassis to produce biochemicals such as carboxylic acids and their derivatives from CO2. In this manuscript, we reflected on cyanobacterial acetyl-CoA pool and TCA cycle as an important source of precursor molecules for the biosynthesis of carboxylic acids such as 3-hydroxypropionate, 3-hydroxybutyrate, succinate, malate, fumarate and free fatty acids, each of which is an important platform chemical for bioeconomy. We further highlighted specific features of the cyanobacterial TCA cycle, how it differs in structure and function from widely described TCA cycles of heterotrophic model organisms, and methods to make it more suitable for the production of carboxylic acids from CO2. Currently, the yields of these compounds are significantly lower than those in heterotrophic organisms and it was concluded that the primary cause of this can be attributed to the limited flux toward acetyl-CoA. Strategies like overexpressing pyruvate dehydrogenase complex or introducing synthetic bypasses are being explored to overcome these limitations. While significant progress has been made, further research is needed to enhance the metabolic efficiency of cyanobacteria, making them viable for the large-scale, sustainable production of carboxylic acids and their derivatives. Full article
(This article belongs to the Special Issue Recent Research of Natural Products from Microalgae and Cyanobacteria)
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