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Research Progress of Metabolomics in Health and Disease
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Research Progress of Metabolomics in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1081

Special Issue Editor

Dr. Maria Assunta Acquavia

E-Mail Website
Guest Editor
Department of Basic and Applied Sciences, University of Basilicata, Viale dell’Ateneo Lucano, 10-85100 Potenza, Italy
Interests: liquid chromatography; mass spectrometry; high-resolution mass spectrometry; food; metabolomics; environment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

To date, metabolomics has emerged as an indispensable platform for the overall analysis of the metabolites, i.e. all the small molecules occurring in the biological systems, including humans, plants, foods, animals and microbes, to discover networks and interactions between them. Moreover, metabolomic studies can help in the discovering of new biomarkers for the diagnosis of health diseases. Studies concerning metabolomics are in continuous progress, allowing new developments in the analytical methods and data analysis tools. This Special Issue is focused on the progresses of the metabolomic technology, both analytical methods and data analysis, in the fields of health and diseases. The topics covered include but are not limited to the application of the modern analytical techniques, such as GC-MS, LC-MS/MS and HRMS, for the comprehensive evaluation of the metabolic fingerprint of biological systems related to the diagnosis and mechanisms elucidations of health diseases involving human or animal samples, or the target identification of specific classes of compounds as well as the manipulation of the big data produced during metabolomic analysis.

Dr. Maria Assunta Acquavia
Guest Editor

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Keywords

  • metabolomics
  • health
  • diseases
  • target metabolites
  • mass spectrometry
  • hyphenated techniques

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Published Papers (1 paper)

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Research

19 pages, 3204 KiB  
Article
Microbiota Co-Metabolism Alterations Precede Changes in the Host Metabolism in the Early Stages of Diet-Induced MASLD in Wistar Rats
by María Martín-Grau, Pilar Casanova, Laura Moreno-Morcillo, José Manuel Morales, Vannina G. Marrachelli and Daniel Monleón
Int. J. Mol. Sci. 2025, 26(3), 1288; https://doi.org/10.3390/ijms26031288 - 2 Feb 2025
Viewed by 443
Abstract
Metabolic-dysfunction-associated steatotic liver disease (MASLD) affects around 30% of the global population. The sexual dimorphism and gut microbiota play an important role in the early development of MASLD. The main objective of this research was to investigate metabolic changes during the early subclinical [...] Read more.
Metabolic-dysfunction-associated steatotic liver disease (MASLD) affects around 30% of the global population. The sexual dimorphism and gut microbiota play an important role in the early development of MASLD. The main objective of this research was to investigate metabolic changes during the early subclinical MASLD progression, for identifying the sequence of events and evaluating the impact of sexual dimorphism and the microbiota on the initial stages of MASLD development. Male and female Wistar rats 18 weeks old were randomly divided into different groups and fed a chow diet or a 45% high-fat diet for 21 weeks. Every three weeks, samples of serum, urine, and faeces were collected and studied by metabolomics. Furthermore, the liver was analysed at the endpoint. In addition, the gut microbiota was analysed from faecal samples over time using 16S rRNA gene-targeted group-specific primers. Our results revealed that three weeks on an HFD reduced the bacterial diversity in the faecal microbiota of Wistar rats, accompanied by changes in the faecal and urine metabolome. The HFD-induced alterations in microbiota-related co-metabolites in the liver, blood, urine, and faeces indicate a significant role of host–microbiota co-metabolism changes in the early stages of MASLD. In this study, we provide a comprehensive longitudinal analysis, detailing the sequence of events in the early development of MASLD. Our findings suggest that alterations in the gut microbiota diversity and co-metabolism occur before changes in host metabolism in the early onset of liver steatosis, a subclinical phase of MASLD. Full article
(This article belongs to the Special Issue Research Progress of Metabolomics in Health and Disease)
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