Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Cyclodextrins: Properties and Applications, 2nd Edition
ijms-logo
Submit to Special Issue Submit Abstract to Special Issue Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Cyclodextrins: Properties and Applications, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 8696

Special Issue Editors

Prof. Dr. Miguel A. Esteso

E-Mail Website
Guest Editor
Faculty of Health Sciences, Catholic University of Ávila, Calle Los Canteros s/n, 05005 Ávila, Spain
Interests: electrochemical thermodynamics; electrolyte solutions; thermodynamic and transport properties; pharmacological chemistry; cyclodextrins
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Carmen M. Romero

E-Mail Website
Guest Editor
Departamento de Química, Universidad Nacional de Colombia, Calle 44 # 45-67 Bloque B9, Bogotá, Colombia
Interests: water and aqueous solutions; chemical thermodynamics; physicochemical behavior of systems that are of biological interest; physicochemical; surface and transport properties of aqueous solutions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cyclodextrins (CDs) continue to attract extensive researcher attention, mainly in relation to their properties as complexing agents and as carriers of different substances, attributes that render them excellent candidates for use in both fundamental and technological applications. For example, the use of these substances as participants in controlled release systems or as promoters of the improved solubility of certain poorly soluble substances is of great interest.

Despite their theoretical and applied importance, little is known about the potentialities of these molecules, necessitating a greater knowledge and understanding of the structure and properties of these macrocycles. In this sense, modifying the structure of the standard CDs in order to obtain new iterations with greater complexing capacity towards different substances, either as a consequence of their inclusion within the cavity of the CD or their bonding to the external portion of the CD, is a promising line of study.

In this Special Issue, research papers or comprehensive reviews related to advances in the knowledge of structure, properties and applications of cyclodextrins (CDs) are welcome.

Prof. Dr. Miguel A. Esteso
Prof. Dr. Carmen M. Romero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cyclodextrins
  • controlled release systems
  • structure modification
  • thermodynamic properties
  • transport properties

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (7 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

12 pages, 5289 KiB  
Article
Easy and Effective Method for α-CD:N2O Host–Guest Complex Formation
by Tsveta P. Sarafska, Maya I. Spassova, Todor M. Dudev, Stiliana M. Pereva, Simeon D. Stoyanov and Tony G. Spassov
Int. J. Mol. Sci. 2024, 25(10), 5472; https://doi.org/10.3390/ijms25105472 - 17 May 2024
Viewed by 775
Abstract
α-CD:N2O “host-guest” type complexes were formed by a simple solid–gas reaction (N2O sorption into α-CD) under different gas pressures and temperatures. The new N2O inclusion method applied in the present study was compared with the already known [...] Read more.
α-CD:N2O “host-guest” type complexes were formed by a simple solid–gas reaction (N2O sorption into α-CD) under different gas pressures and temperatures. The new N2O inclusion method applied in the present study was compared with the already known technique based on the crystallization of clathrates from a water solution of α-CD saturated with N2O. A maximum storage capacity of 4.5 wt.% N2O was achieved when charging the cyclodextrin from a gas phase. The amount of included gas decreases to 1.3 wt.% when the complex is stored in air at 1 atm and room temperature, analogous to that achieved by the crystallization of α-CD:N2O. Furthermore, it was shown that the external coordination of N2O to either the upper or lower rim of α-CD without hydration water displacement is the preferred mode of binding, due to hydrogen bonds with neighboring -OH groups from the host macrocycle and three of the hydration water molecules nearby. The capacity of α-CD to store N2O and the thermal stability of the α-CD:N2O complex demonstrated promising applications of these types of complexes in food and beverages. Full article
(This article belongs to the Special Issue Cyclodextrins: Properties and Applications, 2nd Edition)
►▼ Show Figures

Figure 1

26 pages, 7576 KiB  
Article
New Hydrophilic Matrix Tablets for the Controlled Released of Chlorzoxazone
by Andreea Creteanu, Gabriela Lisa, Cornelia Vasile, Maria-Cristina Popescu, Daniela Pamfil, Claudiu N. Lungu, Alina Diana Panainte and Gladiola Tantaru
Int. J. Mol. Sci. 2024, 25(10), 5137; https://doi.org/10.3390/ijms25105137 - 9 May 2024
Cited by 1 | Viewed by 1171
Abstract
The modified release of active substances such as chlorzoxazone from matrix tablets, based on Kollidon®SR and chitosan, depends both on the drug solubility in the dissolution medium and on the matrix composition. The aim of this study is to obtain some [...] Read more.
The modified release of active substances such as chlorzoxazone from matrix tablets, based on Kollidon®SR and chitosan, depends both on the drug solubility in the dissolution medium and on the matrix composition. The aim of this study is to obtain some new oral matrix tablet formulations, based on Kollidon®SR and chitosan, in order to optimize the low-dose oral bioavailability of chlorzoxazone, a non-steroidal anti-inflammatory drug of class II Biopharmaceutical Classification System. Nine types of chlorzoxazone matrix tablets were obtained using the direct compression method by varying the components ratio as 1:1, 1:2, and 1:3 chlorzoxazone/excipients, 20–40 w/w % Kollidon®SR, 3–7 w/w % chitosan while the auxiliary substances: Aerosil® 1 w/w %, magnesium stearate 0.5 w/w % and Avicel® up to 100 w/w % were kept in constant concentrations. Pharmaco-technical characterization of the tablets included the analysis of flowability and compressibility properties (flow time, friction coefficient, angle of repose, Hausner ratio, and Carr index), and pharmaco-chemical characteristics (such as mass and dose uniformity, thickness, diameter, mechanical strength, friability, softening degree, and in vitro release profiles). Based on the obtained results, only three matrix tablet formulations (F1b, F2b, and F3b, containing 30 w/w % KOL and 5 w/w % CHT, were selected and further tested. These formulations were studied in detail by Fourier-transform infrared spectrometry, X-ray diffraction, thermogravimetry, and differential scanning calorimetry. The three formulations were comparatively studied regarding the release kinetics of active substances using in vitro release testing. The results were analyzed by fitting into four representative mathematical models for the modified-release oral formulations. In vitro kinetic study revealed a complex mechanism of release occurring in two steps of drug release, the first step (0–2 h) and the second (2–36 h). Two factors were calculated to assess the release profile of chlorzoxazone: f1—the similarity factor, and f2—the factor difference. The results have shown that both Kollidon®SR and chitosan may be used as matrix-forming agents when combined with chlorzoxazone. The three formulations showed optima pharmaco-technical properties and in vitro kinetic behavior; therefore, they have tremendous potential to be used in oral pharmaceutical products for the controlled delivery of chlorzoxazone. In vitro dissolution tests revealed a faster drug release for the F2b sample. Full article
(This article belongs to the Special Issue Cyclodextrins: Properties and Applications, 2nd Edition)
►▼ Show Figures

Figure 1

26 pages, 3577 KiB  
Article
Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut–Brain Axes in Physiology and IBS Syndrome
by Francesca Uberti, Francesco Trotta, Roberta Cavalli, Rebecca Galla, Fabrizio Caldera, Sara Ferrari, Simone Mulè, Arianna Brovero, Claudio Molinari, Pasquale Pagliaro and Claudia Penna
Int. J. Mol. Sci. 2024, 25(4), 2189; https://doi.org/10.3390/ijms25042189 - 11 Feb 2024
Cited by 3 | Viewed by 1649
Abstract
Vitamin D3 (VitD3) plays a crucial role in various cellular functions through its receptor interaction. The biological activity of Vitamin D3 can vary based on its solubility and stability. Thus, the challenge lies in maximizing its biological effects through its complexation within cyclodextrin [...] Read more.
Vitamin D3 (VitD3) plays a crucial role in various cellular functions through its receptor interaction. The biological activity of Vitamin D3 can vary based on its solubility and stability. Thus, the challenge lies in maximizing its biological effects through its complexation within cyclodextrin (βNS-CDI 1:4) nanosponges (NS) (defined as VitD3NS). Therefore, its activity has been evaluated on two different gut–brain axes (healthy gut/degenerative brain and inflammatory bowel syndrome gut/degenerative brain axis). At the gut level, VitD3-NS mitigated liposaccharide-induced damage (100 ng/mL; for 48 h), restoring viability, integrity, and activity of tight junctions and reducing ROS production, lipid peroxidation, and cytokines levels. Following intestinal transit, VitD3-NS improved the neurodegenerative condition in the healthy axis and the IBS model, suggesting the ability of VitD3-NS to preserve efficacy and beneficial effects even in IBS conditions. In conclusion, this study demonstrates the ability of this novel form of VitD3, named VitD3-NS, to act on the gut–brain axis in healthy and damaged conditions, emphasizing enhanced biological activity through VitD3 complexation, as such complexation increases the beneficial effect of vitamin D3 in both the gut and brain by about 50%. Full article
(This article belongs to the Special Issue Cyclodextrins: Properties and Applications, 2nd Edition)
►▼ Show Figures

Figure 1

20 pages, 10787 KiB  
Article
Formulation Studies with Cyclodextrins for Novel Selenium NSAID Derivatives
by Sandra Ramos-Inza, Cristina Morán-Serradilla, Leire Gaviria-Soteras, Arun K. Sharma, Daniel Plano, Carmen Sanmartín and María Font
Int. J. Mol. Sci. 2024, 25(3), 1532; https://doi.org/10.3390/ijms25031532 - 26 Jan 2024
Cited by 1 | Viewed by 1192
Abstract
Commercial cyclodextrins (CDs) are commonly used to form inclusion complexes (ICs) with different molecules in order to enhance their water solubility, stability, and bioavailability. Nowadays, there is strong, convincing evidence of the anticancer effect of selenium (Se)-containing compounds. However, pharmaceutical limitations, such as [...] Read more.
Commercial cyclodextrins (CDs) are commonly used to form inclusion complexes (ICs) with different molecules in order to enhance their water solubility, stability, and bioavailability. Nowadays, there is strong, convincing evidence of the anticancer effect of selenium (Se)-containing compounds. However, pharmaceutical limitations, such as an unpleasant taste or poor aqueous solubility, impede their further evaluation and clinical use. In this work, we study the enhancement of solubility with CD complexes for a set of different nonsteroidal anti-inflammatory drug (NSAID) derivatives with Se as selenoester or diacyl diselenide chemical forms, with demonstrated antitumoral activity. The CD complexes were analyzed via nuclear magnetic resonance (NMR) spectroscopic techniques. In order to obtain additional data that could help explain the experimental results obtained, 3D models of the theoretical CD-compound complexes were constructed using molecular modeling techniques. Among all the compounds, I.3e and II.5 showed a remarkable increase in their water solubility, which could be ascribed to the formation of the most stable interactions with the CDs used, in agreement with the in silico studies performed. Thus, the preliminary results obtained in this work led us to confirm the selection of β and γ-CD as the most suitable for overcoming the pharmaceutical drawbacks of these Se derivatives. Full article
(This article belongs to the Special Issue Cyclodextrins: Properties and Applications, 2nd Edition)
►▼ Show Figures

Figure 1

Review

Jump to: Research

15 pages, 3457 KiB  
Review
Cyclodextrin-Containing Drug Delivery Systems and Their Applications in Neurodegenerative Disorders
by Yuan Xing, Bohan Meng and Qi Chen
Int. J. Mol. Sci. 2024, 25(19), 10834; https://doi.org/10.3390/ijms251910834 - 9 Oct 2024
Viewed by 1155
Abstract
Cyclodextrins (CDs) are ubiquitous excipients, constituted of cyclic glucopyranose units, and possess a unique dual nature, that of a hydrophobic interior and a hydrophilic exterior. This enables their interaction with lipid-affinitive compounds and hydrophilic compounds, thereby augmenting their application in pharmaceutical formulations as [...] Read more.
Cyclodextrins (CDs) are ubiquitous excipients, constituted of cyclic glucopyranose units, and possess a unique dual nature, that of a hydrophobic interior and a hydrophilic exterior. This enables their interaction with lipid-affinitive compounds and hydrophilic compounds, thereby augmenting their application in pharmaceutical formulations as agents for improving solubility, as well as fundamental elements of advanced drug delivery systems. Additionally, CDs, upon suitable modification, can strategically participate in the interaction with cellular components and physical barriers, such as the blood–brain barrier, where their intricate and multifunctional engagement leads to various biological impacts. This review consolidates the crucial features of CDs and their derivatives, and summarizes the applications of them as drug delivery systems in neurodegenerative disorders, emphasizing their notable potentials. Full article
(This article belongs to the Special Issue Cyclodextrins: Properties and Applications, 2nd Edition)
►▼ Show Figures

Figure 1

56 pages, 4348 KiB  
Review
Review of Applications of β-Cyclodextrin as a Chiral Selector for Effective Enantioseparation
by Ewa Napiórkowska and Łukasz Szeleszczuk
Int. J. Mol. Sci. 2024, 25(18), 10126; https://doi.org/10.3390/ijms251810126 - 20 Sep 2024
Viewed by 990
Abstract
The significance and necessity of separating enantiomers in food, pharmaceuticals, pesticides, and other samples remains constant and unrelenting. The successful chiral separation usually includes the application of a chiral auxiliary compound, known also as a chiral selector (CS), that forms complexes with enantiomers [...] Read more.
The significance and necessity of separating enantiomers in food, pharmaceuticals, pesticides, and other samples remains constant and unrelenting. The successful chiral separation usually includes the application of a chiral auxiliary compound, known also as a chiral selector (CS), that forms complexes with enantiomers of different physicochemical properties, enabling efficient separation. While both native and substituted cyclodextrins (CDs) are commonly used as CSs, β-CD is undoubtedly the most popular one among them. This review includes recent advancements in the application of β-CD as a CS. While the theoretical background behind the enantioseparation is also part of this work, the main emphasis is put on the factors that affect the efficacy of this process such as temperature, pH, solvent, and the choice of other additives. Also, the different analytical methods: Nuclear Magnetic Resonance (NMR) spectroscopy, Capillary Electrophoresis (CE), fluorescence spectroscopy (FS), High-Performance Liquid Chromatography (HPLC), Isothermal Titration Calorimetry (ITC), and UV–vis spectroscopy, used for enantioseparation with the aid of β-CD as CS, are thoroughly compared. Also, since some of the chiral compounds have been studied in the context of their enantioseparation more than once, those works are compared and critically analyzed. In conclusion, while β-CD can be in most cases used as CS, the choice of the experimental conditions and method of analysis is crucial to achieve the success. Full article
(This article belongs to the Special Issue Cyclodextrins: Properties and Applications, 2nd Edition)
►▼ Show Figures

Figure 1

25 pages, 9915 KiB  
Review
Following the Trace of Cyclodextrins on the Selenium and Tellurium Odyssey
by Cristina Morán-Serradilla, Daniel Plano, Arun K. Sharma and Carmen Sanmartín
Int. J. Mol. Sci. 2024, 25(14), 7799; https://doi.org/10.3390/ijms25147799 - 16 Jul 2024
Cited by 1 | Viewed by 853
Abstract
There is an urgent need to develop safer and more effective modalities for the treatment of numerous pathologies due to the increasing rates of drug resistance, undesired side effects, poor clinical outcomes, etc. Over the past decades, cyclodextrins (CDs) have gathered great attention [...] Read more.
There is an urgent need to develop safer and more effective modalities for the treatment of numerous pathologies due to the increasing rates of drug resistance, undesired side effects, poor clinical outcomes, etc. Over the past decades, cyclodextrins (CDs) have gathered great attention as potential drug carriers due to their ability to enhance their bioactivities and properties. Likewise, selenium (Se) and tellurium (Te) have been extensively studied during the last decades due to their possible therapeutical applications. Although there is limited research on the relationship between Se and Te and CDs, herein, we highlight different representative examples of the advances related to this topic as well as give our view on the future directions of this emerging area of research. This review encompasses three different aspects of this relationship: (1) modification of the structure of the different CDs; (2) formation of host–guest interaction complexes of naïve CDs with Se and Te derivatives in order to overcome specific limitations of the latter; and (3) the use of CDs as catalysts to achieve novel Se and Te compounds. Full article
(This article belongs to the Special Issue Cyclodextrins: Properties and Applications, 2nd Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-7
Back to TopTop