Macrophage Activation, Natural Products and Inflammatory Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 3598
Special Issue Editors
Interests: inflammation; macrophage; cytokine; herbal medicine; nitric oxide; CHOP; ER stress; immunity; infection
Special Issues, Collections and Topics in MDPI journals
Interests: obesity; metabolic syndrome; inflammation; macrophage; natural product
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Macrophages can be classified as M1 and M2 macrophages based on their polarization. M1 macrophages are classically activated by lipopolysaccharide and IFN-γ derived from tissue necrosis. After activation, M1 macrophages produce proinflammatory cytokines and phagocytize foreign microbes, thereby initiating an immune response. M2 macrophages, on the other hand, are alternatively activated by specific cytokines, such as IL-4, IL-10, or IL-13, decrease inflammation, and play crucial roles in wound healing, tissue repair, and tumor progression. In relation to atherosclerosis progression and regression, M1 macrophages predominate in progression and contribute to the inflammatory state, whereas M2 macrophages are enriched in many models of regression and appear to participate in inflammation resolution and plaque remodeling. Therefore, controlling the activity of macrophages can be an excellent strategy for controlling the inflammatory response provoked by infection, tissue repair, tumor progression, and atherosclerosis. Recently, there have been many reports of various natural products that can control macrophage activation. In this Special Issue, we will examine the action of natural products on macrophage activation and their potential as a treatment for inflammatory diseases or cancer progression. With this in mind, we are pleased to open this Special Issue for submissions.
Topics of interest include, but are not limited to:
- Anti-inflammatory natural products with cytokine storm;
- Action of natural products on acute inflammation;
- Effect of natural products on chronic inflammatory diseases;
- Future perspectives for anti-inflammatory natural products with macrophage activation;
- Mechanisms of action of natural products;
- Effect of natural products on arteriosclerosis;
- Effect of natural products on tumor angiogenesis.
Prof. Dr. Wansu Park
Prof. Dr. Jai-eun Kim
Prof. Dr. Han-Sol Jeong
Guest Editors
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Keywords
- natural product
- macrophage
- macrophage activation
- anti-inflammation
- cytokine
- nitric oxide
- cytosolic calcium
- endoplasmic reticulum stress
- cytokine storm
- CHOP
- pyroptosis
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