Pharmacodynamics Modeling of Anti-inflammatory Drugs (2nd Edition)
A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".
Deadline for manuscript submissions: 5 March 2025 | Viewed by 65
Special Issue Editors
Interests: inflammation; macrophage; cytokine; herbal medicine; nitric oxide; CHOP; ER stress; immunity; infection
Special Issues, Collections and Topics in MDPI journals
Interests: neurotoxicity; neurodegenerative disorders; Parkinson’s disease; natural product
Special Issues, Collections and Topics in MDPI journals
Interests: obesity; metabolic syndrome; inflammation; macrophage; natural product
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immunity is an essential function in protecting the host from pathogenic infections. However, inflammation that persists for too long or is uncontrolled can sometimes develop into a disease that can be harmful to health and even threaten life. For example, cytokine storms caused by viral infections might provoke lung damage and cause acute respiratory distress syndrome. In addition, many reports have been suggested about inflammation-related carcinogenesis. Cancer-associated inflammation includes leukocyte infiltration, expression of cytokines (including chemokines and growth factors), tissue remodeling, and angiogenesis. In addition to cancer development, unregulated inflammatory responses might contribute to chronic inflammatory diseases such as lupus, atherosclerosis, rheumatoid arthritis, osteoarthritis, psoriasis, vasculitis, chronic obstructive pulmonary disease, and irritable bowel disease. Inflammation that is not resolved in the brain nervous system causes damage or dysfunction of brain tissue and is associated with acute and chronic brain diseases. Thus, it is reasonable that biomedical research needs to be performed for not only the removal of invading pathogens but also for the regulation of immune and inflammatory responses. Recently, various natural products have been reported to have anti-inflammatory and analgesic effects. For clinical usages, a more detailed investigation including calcium signaling pathway in vitro or serum cytokine level in vivo deserves to be carried out. In addition, investigating the regulatory action of natural products on endoplasmic reticulum stress, which is associated with the occurrence of various diseases, may provide a new vision for the development of treatments for intractable diseases.
This Special Issue on “Pharmacodynamics Modeling of Anti-inflammatory Drugs (2nd Edition)” aims to establish a more detailed mechanism of action for natural products appropriate for precision medicine. Topics include, but are not limited to, the following:
- Development of new natural products to modulate the hyperproduction of cytokines in macrophages induced by pathogens;
- Evaluation of the anti-inflammatory effects of natural products by suppressing the activation of the STAT pathway;
- Research on the calcium signaling pathway in inflammation alleviated by natural products;
- Study of the effects of natural products on inflammatory diseases related with mitogen-activated protein kinase;
- Investigation of analgesic and anti-inflammatory effects of natural products with the serum cytokine level;
- Study of the regulatory effects of natural products on the endoplasmic reticulum stress-related signaling pathway.
Prof. Dr. Wansu Park
Prof. Dr. Myung Sook Oh
Prof. Dr. Jai-Eun Kim
Guest Editors
Manuscript Submission Information
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Keywords
- pharmacodynamics
- inflammation
- anti-inflammation
- analgesic
- endoplasmic reticulum stress
- calcium
- MAPK
- STAT
- natural product
- cytokine
- nitric oxide
- immune cell
- macrophage
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