The Bidirectional Biological Interaction Between Periodontal Disease and Diabetes Mellitus
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 6881
Special Issue Editors
Interests: periodontal disease; dental implants; human genetics; diabetes; inflammation
Interests: nanoparticles; wound healing; inorganic nanoparticles; drug delivery systems
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
There is growing evidence that diabetes mellitus (DM) has a significant impact on the pathogenesis of oral conditions, such as periodontal disease (PD) and apical periodontitis, increasing their risk and severity. PD is a chronic inflammatory condition associated with dysbiotic dental biofilm, which activates the host immune response and causes alveolar bone destruction and collagen degradation. The host immune response is modified by diabetes and might play a causative role in bacteria-induced tissue damage. On the other hand, persistent local infections, such as periodontitis, could induce or perpetuate low-grade chronic systemic inflammation, which may contribute to altered glycemic metabolism, eventually leading to a hyperglycemic state and diabetic complications. Altered glycemic metabolism can enhance the release of proinflammatory cytokines, increasing the risk of local and systemic complications. Understanding the influence of DM on inflammatory bone resorption and its impact on the quality of life of affected patients is crucial for successful management and treatment. Therefore, additional research is required to clarify how the interconnection among different factors, such as the microbiome, genome, inflammasome, proteome, and others, might influence the pathogenesis of these conditions.
All levels of scientific evidence (in vitro, preclinical, observational—cross-sectional or prospective—studies, and randomized clinical trials) will be considered. Meta-analyses, review articles, and systematic reviews are also welcome.
Potential topics include, but are not limited to, the following:
- Potential role of the oral microbiome on the bidirectional relationship between diabetes and periodontal disease or apical periodontitis;
- Mechanisms and pathways related to the bidirectional relationship between diabetes and periodontal disease or apical periodontitis;
- Assessing both oral and systemic outcomes for prevention and treatment strategies for managing comorbidities;
- Common biomarkers for screening these diseases alone or together;
- Evidence of the strength of the association between diabetes and periodontal disease or apical periodontitis.
Dr. Raquel M. Scarel-Caminaga
Dr. Rafael Scaf De Molon
Guest Editors
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Keywords
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diabetes mellitus
- diabetes complications
- periodontitis
- periodontal disease
- etiology
- pathogenesis
- genetic pleiotropy
- animal model
- bone
- microbiome
- inflammation
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