Advances in Structure–Function Investigations of Viruses
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".
Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 1659
Special Issue Editor
Interests: structural biology; 3D image reconstruction; microscopy; vaccine design; virus structures; molecular medicine; genomics; proteomics; metabolomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The current wealth of knowledge on high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living architectures. This Special Issue, “Advances in Structure–Function Investigations of Viruses”, includes case studies aiming to reflect highly coherent interplays between macromolecular structures and evolved functions illuminated by studies of microscopy, crystallography, spectroscopy, and computer modeling. This Special Issue will provide biologists with a broad forum to exchange structural descriptors of fascinating virus systems for brainstorming novel solutions in biomedicine collectively in one volume.
Modern molecular and cellular biology instrumentation provides a potent array of wave packets to image, detect, and manipulate major dynamics of macromolecular and subviral assemblies as in the host cellular context. The folding of a polypeptide chain creates local environments from which “activity” can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be feasible in a large construct. The biological implications of such adaptation are explored as it applies to static quasi-symmetry situations and the dynamics of structural transitions. Consequently, virus infections involve the utilization of large macromolecular assemblies as a dynamic consequence of cooperativity and metastability. The compilation and integration of the methodology provide time-resolved observations on the reactivity of structures from near-atomic resolution to various molecular or cellular levels of descriptors. This Special Issue welcomes exploration of extended themes in intracellular networking/compartmentation utilized in the cell entry and replication cycles by various viruses.
With contributions by leading scientists in the field like you, this crucially timed Special Issue presents cutting-edge knowledge in the various fields of structural proteomics of substantial molecular assemblies, focusing on their mechanisms of action. This Special Issue will provide updates on concurrent research to further aid in solving epidemics and designing innovative nanomaterials for the 21st century.
Prof. Dr. R. Holland Cheng
Guest Editor
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Keywords
- structure
- assembly
- viruses
- crystallography
- spectroscopy
- computer modeling
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