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5-ISPMF Special Issue: Phytochemicals in Cardiovascular and Metabolic Diseases-Molecular Pharmacology and Therapeutic Potential

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 7245

Special Issue Editors

Prof. Dr. Suowen Xu

E-Mail Website
Guest Editor
Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China
Interests: cardiovascular pharmacology; natural products; atherosclerosis; therapy; epigenetics; aging; inflammation; metabolism; therapeutic targets; mechanopharmacology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Peter J. Little

E-Mail Website
Guest Editor
1. School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba 4102, Queensland, Australia
2. Deperatnment of Pharmacy, Xinhua College of Sun Yat sen University, Tianhe District, Guangzhou 510520, Guangdong, China
Interests: diabetes; cardiovascular complications; atherosclerosis; proteoglycans and glycosaminoglycans; cellular signaling; Smad transcription factors; natural product pharmacology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jianping Weng

E-Mail Website
Guest Editor
Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China
Interests: diabetes; natural products; non-alcoholic fatty liver disease; pharmacotherapy

Special Issue Information

Dear Colleauges,

Cardiovascular and metabolic diseases represent the two types of non-communicable chronic diseases with high levels of morbidity, mortality, and persistently increasing prevalence and they represent a major health and economic burden across the entire globe. The extent of the issue is such that although there are existing therapeutic options, there is an ongoing need for novel therapies based on existing and emerging knowledge of the underlying disease mechanisms. Phytochemicals including those from natural sources, such as food supplements, spices, herbal medicines, marine products, and other products represent an important source of drug discovery. In particular, the emergence of high content screening and high throughput screening from drug libraries consisting of natural product libraries or bioactive naturally-occurring compound libraries has enabled the discovery of new drug candidates. We are guest editing this Special Issue to celebrate the 5th International Symposium on Phytochemicals in Medicine and Food (5-ISPMF) in Nanchang, China (2021.8.25-2021.8.30). All submissions related to the below topics from scientists working on phytochemicals are welcome.

Suggested Topics:

  1. New therapeutic targets in cardiovascular and metabolic diseases
  2. Current treatment options for cardiovascular and metabolic diseases
  3. Natural product-based drug discovery in combating cardiometabolic diseases
  4. Traditional Chinese medicine and its bioactive constituents in cell and animal model of cardiometabolic diseases
  5. Role of phytochemicals in cell metabolism
  6. Pharmacological actions and therapeutic potential of plant-derived compounds/drugs
  7. Ethnopharmacology and other herbal medicine in treating cardiometabolic diseases
  8. High content or high throughput compound screening from bioactive phytochemical drug library
  9. Clinical trials of phytochemicals in treating cardiometabolic diseases

Prof. Dr. Suowen Xu
Prof. Dr. Peter Little
Prof. Dr. Jianping Weng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disease
  • metabolic disease
  • diabetes
  • fatty liver
  • obesity
  • phytochemicals
  • therapy
  • natural products
  • herbal medicine
  • drug discovery

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Published Papers (2 papers)

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Research

17 pages, 2801 KiB  
Article
Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling
by Chen-Sheng Chen, Bo-Yi Pan, Ping-Hsuan Tsai, Fang-Yu Chen, Wen-Chin Yang and Ming-Yi Shen
Int. J. Mol. Sci. 2021, 22(19), 10309; https://doi.org/10.3390/ijms221910309 - 24 Sep 2021
Cited by 8 | Viewed by 2729
Abstract
Reactive oxygen species (ROS)-induced vascular endothelial cell apoptosis is strongly associated with atherosclerosis progression. Herein, we aimed to examine whether Kansuinine A (KA), extracted from Euphorbia kansui L., prevents atherosclerosis development in a mouse model and inhibits cell apoptosis through oxidative stress reduction. [...] Read more.
Reactive oxygen species (ROS)-induced vascular endothelial cell apoptosis is strongly associated with atherosclerosis progression. Herein, we aimed to examine whether Kansuinine A (KA), extracted from Euphorbia kansui L., prevents atherosclerosis development in a mouse model and inhibits cell apoptosis through oxidative stress reduction. Atherosclerosis development was analyzed in apolipoprotein E-deficient (ApoE−/−) mice fed a high-fat diet (HFD) using Oil Red O staining and H&E staining. Human aortic endothelial cells (HAECs) were treated with KA, followed by hydrogen peroxide (H2O2), to investigate the KA-mediated inhibition of ROS-induced oxidative stress and cell apoptosis. Oil Red O staining and H&E staining showed that atherosclerotic lesion size was significantly smaller in the aortic arch of ApoE−/− mice in the HFD+KA group than that in the aortic arch of those in the HFD group. Further, KA (0.1–1.0 μM) blocked the H2O2-induced death of HAECs and ROS generation. The H2O2-mediated upregulation of phosphorylated IKKβ, phosphorylated IκBα, and phosphorylated NF-κB was suppressed by KA. KA also reduced the Bax/Bcl-2 ratio and cleaved caspase-3 expression, preventing H2O2-induced vascular endothelial cell apoptosis. Our results indicate that KA may protect against ROS-induced endothelial cell apoptosis and has considerable clinical potential in the prevention of atherosclerosis and cardiovascular diseases. Full article
(This article belongs to the Special Issue 5-ISPMF Special Issue: Phytochemicals in Cardiovascular and Metabolic Diseases-Molecular Pharmacology and Therapeutic Potential)
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17 pages, 33491 KiB  
Article
Potassium Alginate Oligosaccharides Alter Gut Microbiota, and Have Potential to Prevent the Development of Hypertension and Heart Failure in Spontaneously Hypertensive Rats
by Zhen-Lian Han, Meng Chen, Xiao-Dan Fu, Min Yang, Maria Hrmova, Yuan-Hui Zhao and Hai-Jin Mou
Int. J. Mol. Sci. 2021, 22(18), 9823; https://doi.org/10.3390/ijms22189823 - 11 Sep 2021
Cited by 23 | Viewed by 3349
Abstract
Food-derived oligosaccharides show promising therapeutic potential in lowering blood pressure (BP), but the mechanism is poorly understood. Recently, the potential role of gut microbiota (GM) in hypertension has been investigated, but the specific GM signature that may participate in hypertension remains unclear. To [...] Read more.
Food-derived oligosaccharides show promising therapeutic potential in lowering blood pressure (BP), but the mechanism is poorly understood. Recently, the potential role of gut microbiota (GM) in hypertension has been investigated, but the specific GM signature that may participate in hypertension remains unclear. To test the potassium alginate oligosaccharides (PAO) mechanism in lowering BP and specific microbial signature changes in altering GM, we administered various dosages of PAO in 40 spontaneously hypertensive rats for a duration of six weeks. We analyzed BP, sequenced the 16S ribosomal DNA gene in the cecum content, and gathered RNA-seq data in cardiac tissues. We showed that the oral administration of PAO could significantly decrease systolic BP and mean arterial pressure. Transcriptome analyses demonstrated that the protective effects of developing heart failure were accompanied by down-regulating of the Natriuretic Peptide A gene expression and by decreasing the concentrations of angiotensin II and atrial natriuretic peptide in plasma. In comparison to the Vehicle control, PAO could increase the microbial diversity by altering the composition of GM. PAO could also decrease the ratio of Firmicutes to Bacteroidetes by decreasing the abundance of Prevotella and Phascolarctobacterium bacteria. The favorable effect of PAO may be added to the positive influence of the abundance of major metabolites produced by Gram-negative bacteria in GM. We suggest that PAO caused changes in GM, and thus, they played an important role in preventing the development of cardiovascular disease. Full article
(This article belongs to the Special Issue 5-ISPMF Special Issue: Phytochemicals in Cardiovascular and Metabolic Diseases-Molecular Pharmacology and Therapeutic Potential)
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