Monoclonal Antibodies & Immunotherapy to Treat Cancer: Current Knowledge, Emerging Targets and Future Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2760
Special Issue Editors
Interests: monoclonal antibodies; cancer; antibodies; treatment; mAbs; immune checkpoint inhibitors; multispecific antibodies
Special Issues, Collections and Topics in MDPI journals
Interests: cancer research; medical oncology; non-small-cell lung cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Monoclonal antibodies (mAbs) are a unique type of targeted drugs which have transformed the therapeutics of cancer. During the last twenty-two years, from the approval of rituximab in 1997 until now, many engineered humanized or chimeric mAbs have been produced and validated in clinical trials, changing the way we understand and treat hematologic and solid malignancies.
The tremendous impact and success of mAbs in cancer management is based on their specificity and selectivity for specific antigens on target cells. MAbs mainly target and destroy cancer cells by interrupting specific oncogenic cell signaling, inducing apoptosis or carrying a conjugated drug, toxin or radioactive substance. One of the most successful applications of mAbs is to empower the immune system to eradicate cancer cells. With the advances in methodological and production techniques, significant improvements are expected in this class of medications, including, but not limiting to, bi-, tri- or multispecific mAbs, newer antibody–drug conjugates (ADCs), antibody-targeted nanoparticles and single-domain antibodies (sdAb).
This Special Issue will cover all aspects of monoclonal antibodies regarding their role in cancer treatment, recent advances in cancer immunotherapy using mAbs, as well as the upcoming antibody products which are investigated in cancer.
Dr. Foteinos-Ioannis Dimitrakopoulos
Prof. Dr. Haralabos Kalofonos
Guest Editors
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