The Brain as a Manager of Central and Peripheral Functions—Molecular Aspects in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 5600
Special Issue Editor
2. Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia
Interests: developmental neurobiology; neuroendocrinology; neurodegenerative diseases; Parkinson’s disease; preclinical diagnosis; preventive neuroprotective therapy
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Special Issue Information
Dear Colleagues,
The brain is actually the conductor or manager of the development of the body, including the brain itself, in ontogenesis, as well as the regulation of central and peripheral functions in adulthood. Thus, the brain controls such crucial central functions - of the brain itself, as consciousness, memory, vision, olfaction, etc., as well as peripheral functions such as reproduction, motor, cardio-vascular, endocrine, etc. Both types of regulation are provided by neuronal ensembles that exchange information using a wide range of intercellular signals—classical, neurotransmitters, neuropeptides, amino acids. These signals are involved in synaptic or volume neurotransmission in the brain, as well as in neuroendocrine regulation, when they are delivered to target cells due to body fluids (CSF, blood). The action of intercellular brain-derived chemical signals during so-called critical period of morphogenesis (perinatal period) is fundamentally different from that in adulthood. Indeed, in the perinatal period before the establishment of the blood brain barrier they exert an irreversible morphogenetic effect on differentiating target cells in the brain and peripheral organs. Disruption of the functioning of the developing brain during the critical period of morphogenesis leads to the development of congenital diseases that are practically not curable during subsequent life. Impairment of the brain operation in adulthood leads to the development of numerous neurological, mental, and neuroendocrine diseases. Some of them, such as neurodegenerative diseases (Alzheimer disease, Parkinson’s disease) are incurable. Data on the molecular mechanisms of brain diseases obtained using cellular and animal models, as well as pathological material, are of particular importance since they can be translated into the development of new technologies for diagnosing and treating patients.
Thus, this Special Issue of IJMS on “The Brain as a Manager of Central and Peripheral Functions—Molecular Aspects in Health and Disease” is open to a wide range of studies on the molecular mechanisms of brain functioning in ontogenesis and in adulthood in health and diseases. Reviews, original papers and new technological developments are welcome.
Prof. Dr. Michael Ugrumov
Guest Editor
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Keywords
- brain
- animals
- humans
- cells
- neural regulation
- neuroendocrine regulation
- synaptic neurotransmission
- volume neurotransmission
- ontogenesis
- blood–brain barrier
- brain diseases
- neurological diseases
- mental diseases
- congenital diseases
- modeling of brain pathology
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