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Anticancer Drug Discovery Based on Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1845

Special Issue Editor


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Guest Editor
Department of Pharmacy, Sunchon National University, Suncheon 57922, Republic of Korea
Interests: anticancer drug discovery; natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer remains a leading cause of death worldwide, and the development of new and effective anticancer drugs is urgently needed. Natural products have a long history of use in traditional medicine, and they have been the inspiration for many modern drugs, including anticancer agents. The vast chemical diversity found in nature provides a rich source of novel structures that can be exploited for the development of new drugs with improved efficacy and safety profiles.

In recent years, there has been growing interest in the discovery of anticancer drugs based on natural products. This is due to several factors, including the increasing prevalence of cancer, the limited efficacy of current treatments, and the need for new drugs that are less toxic and have fewer side effects.

Natural products offer several advantages for the discovery of anticancer drugs. They are typically well tolerated by the body, they often have multiple mechanisms of action, and they can be used in combination with other drugs to improve efficacy and reduce toxicity.

We are inviting submissions to this Special Issue of IJMS, titled "Anticancer Drug Discovery Based on Natural Products".

Suggested topics of interest for this Special Issue include, but are not limited to, the following:

  • Discovery of novel anticancer agents from natural sources;
  • Preclinical and clinical studies of natural products for cancer treatment;
  • Mechanisms of action of natural products in cancer cells;
  • Development of natural product-based combination therapies for cancer;
  • Natural products for cancer prevention and chemoprevention.

Prof. Dr. Su-Yun Lyu
Guest Editor

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Keywords

  • anticancer drug discovery
  • natural products
  • phytochemicals
  • traditional medicine
  • drug development
  • preclinical studies
  • clinical trials

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Published Papers (2 papers)

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Research

16 pages, 2597 KiB  
Article
Enhanced Photodynamic Therapy Efficacy through Solid Lipid Nanoparticle of Purpurin-18-N-Propylimide Methyl Ester for Cancer Treatment
by Sooho Yeo, Huiqiang Wu, Il Yoon, Hye-Soo Kim, Young Kyu Song and Woo Kyoung Lee
Int. J. Mol. Sci. 2024, 25(19), 10382; https://doi.org/10.3390/ijms251910382 - 26 Sep 2024
Viewed by 616
Abstract
Photodynamic therapy (PDT) is an innovative cancer treatment that utilizes light. When light irradiates, purpurin-18-N-propylimide methyl ester (P18 N PI ME) generates reactive oxygen species that destroy cancer cells. The hydrophobic nature of P18 N PI ME presents challenges regarding its aggregation in [...] Read more.
Photodynamic therapy (PDT) is an innovative cancer treatment that utilizes light. When light irradiates, purpurin-18-N-propylimide methyl ester (P18 N PI ME) generates reactive oxygen species that destroy cancer cells. The hydrophobic nature of P18 N PI ME presents challenges regarding its aggregation in the body, which can affect its effectiveness. This study aimed to enhance the bioavailability and effectiveness of cancer treatment by synthesizing P18 N PI ME and formulating P18 N PI ME-loaded solid lipid nanoparticles (SLNs). The efficacy of PDT was estimated using the 1,3-diphenylisobenzofuran (DPBF) assay and photocytotoxicity tests on the HeLa (human cervical carcinoma) and A549 (human lung carcinoma) cell lines. The P18 N PI ME-loaded SLNs demonstrated particle sizes in the range of 158.59 nm to 248.43 nm and zeta potentials in the range of –15.97 mV to –28.73 mV. These SLNs exhibited sustained release of P18 N PI ME. DPBF analysis revealed enhanced PDT effects with SLNs containing P18 N PI ME compared with standalone P18 N PI MEs. Photocytotoxicity assays indicated toxicity under light irradiation but no toxicity in the dark. Furthermore, the smallest-sized formulation exhibited the most effective photodynamic activity. These findings indicate the potential of P18 N PI ME-loaded SLNs as promising strategies for PDT in cancer therapy. Full article
(This article belongs to the Special Issue Anticancer Drug Discovery Based on Natural Products)
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21 pages, 4910 KiB  
Article
Modulation of Breast Cancer Cell Apoptosis and Macrophage Polarization by Mistletoe Lectin in 2D and 3D Models
by Chang-Eui Hong and Su-Yun Lyu
Int. J. Mol. Sci. 2024, 25(15), 8459; https://doi.org/10.3390/ijms25158459 - 2 Aug 2024
Viewed by 833
Abstract
Korean mistletoe (Viscum album L. var. coloratum) is renowned for its medicinal properties, including anti-cancer and immunoadjuvant effects. This study aimed to elucidate the mechanisms by which Korean mistletoe lectin (V. album L. var. coloratum agglutinin; VCA) modulates breast cancer [...] Read more.
Korean mistletoe (Viscum album L. var. coloratum) is renowned for its medicinal properties, including anti-cancer and immunoadjuvant effects. This study aimed to elucidate the mechanisms by which Korean mistletoe lectin (V. album L. var. coloratum agglutinin; VCA) modulates breast cancer cell apoptosis and macrophage polarization. The specific objectives were to (1) investigate the direct effects of VCA on MCF-7 breast cancer cells and THP-1-derived M1/M2 macrophages; (2) analyze the impact of VCA on the paracrine interactions between these cell types; and (3) compare the efficacy of VCA in 2D vs. 3D co-culture models to bridge the gap between in vitro and in vivo studies. We employed both 2D and 3D models, co-culturing human M1/M2 macrophages with human MCF-7 breast cancer cells in a Transwell system. Our research demonstrated that M1 and M2 macrophages significantly influenced the immune and apoptotic responses of breast cancer cells when exposed to VCA. M1 macrophages exhibited cytotoxic characteristics and enhanced VCA-induced apoptosis in both 2D and 3D co-culture models. Conversely, M2 macrophages initially displayed a protective effect by reducing apoptosis in breast cancer cells, but this protective effect was reversed upon exposure to VCA. Furthermore, our findings illustrate VCA’s ability to modulate M1 and M2 polarization in breast cancer cells. Finally, the use of magnetic 3D cell cultures suggests their potential to yield results comparable to conventional 2D cultures, bridging the gap between in vitro and in vivo studies. Full article
(This article belongs to the Special Issue Anticancer Drug Discovery Based on Natural Products)
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