Targeting Dysregulated RNA Processing in Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 4847
Special Issue Editor
Interests: cancer therapy development; therapeutic target discovery; functional genetic screening; oncolytic immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Emerging data show that co-transcriptional and post-transcriptional modifications of protein-encoding messenger RNAs are important determinants of disease development and progression, response to treatment and drug resistance. Aberrant RNA methylation, splicing and editing affect mRNA transport and stability, as well as its translation into protein isoforms with distinct or even opposing functions. Alternative mRNA splicing products and loss of canonically spliced variants were shown to correlate with stage and progression in malignancy. Frequent somatic mutations in regulators of RNA modification and altered splicing patterns in key cancer-associated genes were found in cancer cells and have been proposed as a hallmark of cancer. A deeper understanding of the molecular mechanisms associated with dysregulated RNA modification and the study of altered RNA modification events can provide key insights into the pathophysiology of disease and pave the way for biomarker discovery and identification of novel therapeutic vulnerabilities. In particular small molecule inhibitors of alternative RNA splicing represent a potentially promising class of anti-cancer agents, currently progressing to clinical development.
This Special Issue of IJMS intends to provide new research results to broaden our understanding of dysregulated RNA processing in disease and its effects on disease progression and treatment efficacy, as well as identification of new biomarkers, therapeutic targets and experimental medicines based on this knowledge. Novel insights that may contribute to more effective cancer treatment are of particular interest for this issue. Authors are invited to submit their original research and timely review articles.
Relevant topics include, but are not limited to:
- Identification of disease-associated patterns of dysregulated RNA processing
- Detection of genetic alterations in cancer that affect RNA processing
- RNA splicing isoforms as potential biomarkers and therapeutic targets
- Structural and functional analysis of RNA modifying proteins
- Discovery of drugs targeting RNA modifying proteins
- Preclinical or clinical evaluation of spliceosome-targeting compounds
- Strategies to modulate oncogenic RNA splicing events
- Bioinformatic analysis methods to study dysregulated RNA processing
- Identification of putative cancer neoantigens formed by aberrant RNA processing
Prof. Dr. Victor van Beusechem
Guest Editor
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Keywords
- RNA splicing
- RNA editing
- RNA methylation
- (supra) spliceosome
- antisense oligonucleotides
- RNA interference
- small molecules
- cancer biomarkers
- cancer therapy
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