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Viral Infections: Physiology, Pathophysiology, Pathogenesis, Diagnosis and Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 890

Special Issue Editors


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Guest Editor
Department of Physiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19 Street, 41-808 Zabrze, Poland
Interests: equine viral infection; insulin resistance; diabetes mellitus; metabolic syndrome; insulin
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Guest Editor
Department of Pathology, Division of Microbiology, Wrocław University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland
Interests: virology; zoonoses; epidemiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Viral infections have long been of interest to physicians and scientists around the world; however, it is only the development of molecular techniques in recent decades that has made it possible to understand many aspects of viral biology and their potential for transmission. Today, viral zoonotic diseases are becoming an increasing threat. This phenomenon is fostered by the increase in the size of both populations (human and animal) and the accompanying anthropogenic environmental degradation, as well as the need to convert wasteland into agricultural land and the interspecies transfer of pathogens resulting from the destruction of wildlife habitats and the environment, and climate change.  In the fight against zoonoses, research indicating the mechanisms by which viruses cross interspecies barriers, their adaptability and mutagenic properties is extremely important.

We are pleased to invite you to submit articles describing and discussing the latest data on the pathogenesis, physiology, molecular biology, diagnosis and treatment of viral infections, with particular emphasis on research at the molecular level. 

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • zoonotic diseases;
  • interspecies barriers in viral infections;
  • virus mutations;
  • pathogenesis of viral infections;
  • oxidative stress in viral infections;
  • molecular diagnostic methods;
  • antiviral drugs/preparations;
  • viral diseases with epidemic potential;
  • physiological mechanisms of viral infections

We look forward to receiving your applications.

Dr. Dominika Marta Stygar
Prof. Dr. Barbara Bażanów
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • viral infections
  • virus mutations
  • molecular diagnostic methods
  • antiviral drugs/preparations
  • viral diseases physiological mechanisms

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Published Papers (1 paper)

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Research

11 pages, 947 KiB  
Article
The Effects of Different Respiratory Viruses on the Oxidative Stress Marker Levels in an In Vitro Model: A Pilot Study
by Barbara Bażanów, Katarzyna Michalczyk, Alina Kafel, Elżbieta Chełmecka, Bronisława Skrzep-Poloczek, Aleksandra Chwirot, Kamil Nikiel, Aleksander Olejnik, Alicja Suchocka, Michał Kukla, Bartosz Bogielski, Jerzy Jochem and Dominika Stygar
Int. J. Mol. Sci. 2024, 25(22), 12088; https://doi.org/10.3390/ijms252212088 - 11 Nov 2024
Viewed by 509
Abstract
Respiratory viruses are among the most common causes of human infections. Examining pathological processes linked to respiratory viral infections is essential for diagnosis, treatment strategies, and developing novel therapeutics. Alterations in oxidative stress levels and homeostasis are significant processes associated with respiratory viral [...] Read more.
Respiratory viruses are among the most common causes of human infections. Examining pathological processes linked to respiratory viral infections is essential for diagnosis, treatment strategies, and developing novel therapeutics. Alterations in oxidative stress levels and homeostasis are significant processes associated with respiratory viral infections. The study aimed to compare selected oxidative stress markers: total oxidative status (TOS), total antioxidant capacity (TAC), and the oxidative stress index (OSI) levels and glutathione peroxidase (GPx) and glutathione reductase (GR) activities in normal (MRC5 cell line) and tumor (A549 cell line) lung cells infected with human coronaviruses (HCoV) OC43 and 229E, human adenovirus type 5 (HAdV5), or human rhinovirus A (HRV A). We observed that a respiratory viral infection more significantly affected non-enzymatic oxidative stress markers in a lung adenocarcinoma model (A549 cells), while human lung fibroblasts (MRC-5 cell line) presented changes in enzymatic and non-enzymatic oxidative stress markers. We suggest that further detailed research is required to analyze this phenomenon. Full article
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