Prostate Cancer: Novel Research and Innovative Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 4926
Special Issue Editor
Interests: cancer research; cancer chemotherapy; molecular biology; cell biology; pharmacology; nanomedicine; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The incidence of prostate cancer (PCa) in Western developed countries is dramatically increasing. The androgen receptor (AR) plays a central role in the pathogenesis and management of PCa. Localized PCa is treated by radical prostatectomy, whereas androgen deprivation therapy combined with chemotherapy is preferred for locally advanced disease. Despite the significant progress made to date, most PCa patients progress to an androgen-independent stage known as castration-resistant PCa (CRPC). AR signalling is still active in the majority of CRPC patients, resulting in a more aggressive and treatment-resistant disease. This condition has raised many questions about the molecular mechanisms involved in tumour recurrence and has stimulated intensive research aimed at improving our knowledge of PCa evolution and identifying new targets.
This Special Issue focuses on the molecular pathways involved in drug-resistant CRPC and on innovative therapeutic strategies that may improve the clinical management of this disease.
Dr. Giovanni Luca Beretta
Guest Editor
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Keywords
- prostate cancer
- therapeutic strategy
- castration-resistant PCa
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